8 research outputs found
Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial
This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary
outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in
women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with
SLE were assigned to either aerobic exercise (n = 26) or usual care (n = 32). The intervention comprised
12 weeks of aerobic exercise (2 sessions X 75 min/week) between 40–75% of the individual’s heart
rate reserve. At baseline and at week 12, arterial stiffness was assessed through pulse wave velocity
(PWV), inflammatory (i.e., high-sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha
[TFN- α], and inteleukin 6 [IL-6]) and oxidative stress (i.e., myeloperoxidase [MPO]) markers were
obtained from blood samples, and cardiorespiratory fitness was assessed (Bruce test). There were no
between-group differences in the changes in arterial stiffness (median PWV difference -0.034, 95% CI
-0.42 to 0.36 m/s; p = 0.860) or hsCRP, TNF-α, IL-6, and MPO (all p > 0.05) at week 12. In comparison
to the control group, the exercise group significantly increased cardiorespiratory fitness (median
difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001). These results suggest that 12 weeks of
progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial
stiffness, inflammation, or oxidative stress in women with SLE.This work was supported by FundaciĂłn para la InvestigaciĂłn Biosanitaria de AndalucĂa Oriental (grant
number: PI-0525-2016) and the Ilustre Colegio Oficial de MĂ©dicos de Granada (Premios de InvestigaciĂłn 2017).
BG-C was supported by the Spanish Ministry of Education (FPU15/00002)
Association of objectively measured physical activity and sedentary time with arterial stiffness in women with systemic lupus erythematosus with mild disease activity
Objectives
To examine the association of objectively measured physical activity (PA) intensity
levels and sedentary time with arterial stiffness in women with systemic lupus erythematosus
(SLE) with mild disease activity and to analyze whether participants meeting the
international PA guidelines have lower arterial stiffness than those not meeting the PA
guidelines.
Methods
The study comprised 47 women with SLE (average age 41.2 [standard deviation 13.9])
years, with clinical and treatment stability during the 6 months prior to the study. PA intensity
levels and sedentary time were objectively measured with triaxial accelerometry. Arterial
stiffness was assessed through pulse wave velocity, evaluated by Mobil-O-Graph® 24h
pulse wave analysis monitor.
Results
The average time in moderate to vigorous PA in bouts of 10 consecutive minutes was
135.1±151.8 minutes per week. There was no association of PA intensity levels and sedentary
time with arterial stiffness, either in crude analyses or after adjusting for potential confounders. Participants who met the international PA guidelines did not show lower pulse
wave velocity than those not meeting them (b = -0.169; 95% CI: -0.480 to 0.143; P = 0.280).
Conclusions
Our results suggest that PA intensity levels and sedentary time are not associated with arterial
stiffness in patients with SLE. Further analyses revealed that patients with SLE meeting
international PA guidelines did not present lower arterial stiffness than those not meeting
the PA guidelines. Future prospective research is needed to better understand the association
of PA and sedentary time with arterial stiffness in patients with SLE.This work was supported by FundaciĂłn
para la InvestigaciĂłn Biosanitaria de Andalucia
Oriental, Grant numbers: PI-0525-2016 (http://
www.fibao.es/; http://www.ibsgranada.es/) to
JAVH. The funder had no role in study design, data collection and analysis, decision to publish, or
preparation of the manuscript
The flowchart of the selection of the patients with systemic lupus erythematosus with mild disease activity (<i>n = 47</i>).
<p>The flowchart of the selection of the patients with systemic lupus erythematosus with mild disease activity (<i>n = 47</i>).</p
Physical activity intensity levels and sedentary time in women with systemic lupus erythematosus <i>(n = 47)</i>.
<p>Physical activity intensity levels and sedentary time in women with systemic lupus erythematosus <i>(n = 47)</i>.</p
Average PWV (95% confidence interval) in women with SLE meeting and not meeting the PA guidelines.
<p>Average PWV (95% confidence interval) in women with SLE meeting and not meeting the PA guidelines.</p
Linear regression models examining the association of physical activity intensity levels and sedentary time with pulse wave velocity in women with systemic lupus erythematosus <i>(n = 47)</i>.
<p>Linear regression models examining the association of physical activity intensity levels and sedentary time with pulse wave velocity in women with systemic lupus erythematosus <i>(n = 47)</i>.</p
Socio-demographic and clinical characteristics in women with systemic lupus erythematosus <i>(n = 47)</i>.
<p>Socio-demographic and clinical characteristics in women with systemic lupus erythematosus <i>(n = 47)</i>.</p
Cardiovascular risk factors in women with systemic lupus erythematosus <i>(n = 47)</i>.
<p>Cardiovascular risk factors in women with systemic lupus erythematosus <i>(n = 47)</i>.</p