Contribution of residential wood combustion to PM10 levels in Portugal

Wood is commonly used in residential combustion for heating purposes; however, it can be a major source of air pollutants, namely fine particles, volatile organic compounds and carbon monoxide. Since 2004, the PM10 daily limit value has been surpassed in Portugal, and the European Commission has stated that plans and programs must be designed in order to reduce these levels. In Portugal, 18% of PM10 emissions are due to residential wood combustion, which may deeply impact the PM10 levels in the atmosphere. The main aim of this study is to investigate the impact of residential wood combustion on the air quality in Portugal. The air quality modelling system MM5/CHIMERE was applied over Portugal for a winter month, for the following three scenarios: the reference scenario, considering the actual emissions of PM10; scenario 1, where residential wood combustion emissions are not considered; and scenario 2, which takes into account a complete conversion from traditional fireplaces to certified appliances (with a 90% reduction in PM emissions). The residential wood combustion contribution to PM10 air quality concentration values during January 2007 ranges from 0 to 14 μg m−3, with a mean contribution of 10 μg m−3 in the Lisboa area and 6 μg m−3 in the Porto region. Concerning the legislated values, the area where the daily average limit value (50 μg m−3) is exceeded decreases by 46% in the simulation when residential combustion is not considered. The modelling results for scenario 2 are not significantly different from those for scenario 1. In summary, the regulation of the residential wood combustion sector is as an effective way to reduce the PM10 levels in the atmosphere as regards air quality plans and programs

Infantile Refsum Disease: Influence of Dietary Treatment on Plasma Phytanic Acid Levels

Infantile Refsum disease (IRD) is one of the less severe of Zellweger spectrum disorders (ZSDs), a group of peroxisomal biogenesis disorders resulting from a generalized peroxisomal function impairment. Increased plasma levels of very long chain fatty acids (VLCFA) and phytanic acid are biomarkers used in IRD diagnosis. Furthermore, an increased plasma level of phytanic acid is known to be associated with neurologic damage. Treatment of IRD is symptomatic and multidisciplinary.The authors report a 3-year-old child, born from consanguineous parents, who presented with developmental delay, retinitis pigmentosa, sensorineural deafness and craniofacial dysmorphisms. While the relative level of plasma C26:0 was slightly increased, other VLCFA were normal. Thus, a detailed characterization of the phenotype was essential to point to a ZSD. Repeatedly increased levels of plasma VLCFA, along with phytanic acid and pristanic acid, deficient dihydroxyacetone phosphate acyltransferase activity in fibroblasts and identification of the homozygous pathogenic mutation c.2528G>A (p.Gly843Asp) in the PEX1 gene, confirmed this diagnosis. Nutritional advice and follow-up was proposed aiming phytanic acid dietary intake reduction. During dietary treatment, plasma levels of phytanic acid decreased to normal, and the patient's development evaluation showed slow progressive acquisition of new competences.This case report highlights the relevance of considering a ZSD in any child with developmental delay who manifests hearing and visual impairment and of performing a systematic biochemical investigation, when plasma VLCFA are mildly increased. During dietary intervention, a biochemical improvement was observed, and the long-term clinical effect of this approach needs to be evaluated.info:eu-repo/semantics/publishedVersio

Insumos necessários para o manejo florestal em área de reserva legal no Acre.

No Acre, as atividades de manejo florestal sustentado estão sendo realizadas por meio de um projeto de pesquisa participativa que envolve a Embrapa Acre e onze pequenos produtores do Projeto de Colonização "Pedro Peixoto". O objetivo do estudo é definir um modelo de exploração sustentável aplicável em projetos de assentamento. A área destinada ao manejo compreende a reserva legal com aproximadamente 40ha, sendo a mesma dividida em compartimentos de 4 hectares, seguindo-se a execução de uma plano de exploração florestal madeireiro.bitstream/CPAF-AC/1564/1/it10.pd

Custo de produção do manejo florestal em áreas de reserva legal de pequenas propriedades em projetos de assentamento.

A estimativa do custo de produção vem se tornando um instrumento indispensável para auxiliar na análise da eficiência de seus componentes e viabilidade de todo processo produtivo. Neste aspecto, este conhecimento torna-se imprescindível para que o produtor obtenha informações confiáveis que contribuam para a escolha da atividade e das práticas utilizadas, identificando pontos críticos e mostrando se seu desempenho é rentável para permanecer no mercado.bitstream/CPAF-AC/1557/1/comunicado95.pd

Spherical and planar three-dimensional anti-de Sitter black holes

The technique of dimensional reduction was used in a recent paper (Zanchin et al, Phys. Rev. D66, 064022,(2002)) where a three-dimensional (3D) Einstein-Maxwell-Dilaton theory was built from the usual four-dimensional (4D) Einstein-Maxwell-Hilbert action for general relativity. Starting from a class of 4D toroidal black holes in asymptotically anti-de Sitter (AdS) spacetimes several 3D black holes were obtained and studied in such a context. In the present work we choose a particular case of the 3D action which presents Maxwell field, dilaton field and an extra scalar field, besides gravity field and a negative cosmological constant, and obtain new 3D static black hole solutions whose horizons may have spherical or planar topology. We show that there is a 3D static spherically symmetric solution analogous to the 4D Reissner-Nordstr\"om-AdS black hole, and obtain other new 3D black holes with planar topology. From the static spherical solutions, new rotating 3D black holes are also obtained and analyzed in some detail.Comment: 27 pages, uses "iopclass" files (Latex2e

Impairment of Adenosinergic System in Rett syndrome: Novel Therapeutic Target to Boost BDNF Signalling

Rett syndrome (RTT; OMIM#312750) is mainly caused by mutations in the X-linked MECP2 gene (methyl-CpG-binding protein 2 gene; OMIM*300005), which leads to impairments in the brain-derived neurotrophic factor (BDNF) signalling. The boost of BDNF mediated effects would be a significant breakthrough but it has been hampered by the difficulty to administer BDNF to the central nervous system. Adenosine, an endogenous neuromodulator, may accomplish that role since through A2AR it potentiates BDNF synaptic actions in healthy animals. We thus characterized several hallmarks of the adenosinergic and BDNF signalling in RTT and explored whether A2AR activation could boost BDNF actions. For this study, the RTT animal model, the Mecp2 knockout (Mecp2-/y) (B6.129P2 (C)-Mecp2tm1.1Bird/J) mouse was used. Whenever possible, parallel data was also obtained from post-mortem brain samples from one RTT patient. Ex vivo extracellular recordings of field excitatory post-synaptic potentials in CA1 hippocampal area were performed to evaluate synaptic transmission and long-term potentiation (LTP). RT-PCR was used to assess mRNA levels and Western Blot or radioligand binding assays were performed to evaluate protein levels. Changes in cortical and hippocampal adenosine content were assessed by liquid chromatography with diode array detection (LC/DAD). Hippocampal ex vivo experiments revealed that the facilitatory actions of BDNF upon LTP is absent in Mecp2-/y mice and that TrkB full-length (TrkB-FL) receptor levels are significantly decreased. Extracts of the hippocampus and cortex of Mecp2-/y mice revealed less adenosine amount as well as less A2AR protein levels when compared to WT littermates, which may partially explain the deficits in adenosinergic tonus in these animals. Remarkably, the lack of BDNF effect on hippocampal LTP in Mecp2-/y mice was overcome by selective activation of A2AR with CGS21680. Overall, in Mecp2-/y mice there is an impairment on adenosinergic system and BDNF signalling. These findings set the stage for adenosine-based pharmacological therapeutic strategies for RTT, highlighting A2AR as a therapeutic target in this devastating pathology.info:eu-repo/semantics/publishedVersio