Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating

We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca$^{2+}$ SR overload.Comment: 6 pages, 3 figure

Electron-Conformational Transformations in Nanoscopic RyR Channels Governing Both the Heart's Contraction and Beating

We show that a simple biophysically based electron-conformational model of RyR channel can explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca2+ sarcoplasmic reticulum overload. © 2011 Pleiades Publishing, Ltd.This work was supported by the Ural Branch, Russian Academy of Sciences, project no. 09 M 14 2001

Strong Doping of the n-Optical Confinement Layer for Increasing Output Power of High- Power Pulsed Laser Diodes in the Eye Safe Wavelength Range

Abstract—An analytical model for internal optical losses at high power in a 1.5 μm laser diode with strong n-doping in the n-side of the optical confinement layer is created. The model includes intervalence band absorption by holes supplied by both current flow and two-photon absorption, as well as the direct two-photon absorption effect. The resulting losses are compared with those in an identical structure with a weakly doped waveguide, and shown to be substantially lower, resulting in a significant improvement in the output power and efficiency in the structure with a strongly doped waveguid

MODIFICATION OF RYANODINE-SENSITIVE CALCIUM RELEASE CHANNELS GATING AND CALCIUM DYNAMICS IN CARDIOMYOCYTES BY TEMPERATURE IN ELECTRON-CONFORMATIONAL THEORY

We took into account a temperature in an Electron-Conformational Model of SR-based Ca2+ Clock (ECM Clock). The results of modelling of ECM Clock show that higher temperature gives lower amplitude of cytosolic Ca2+ and higher frequency of oscillations and lower temperature destroys ECM Clock.Исследования поддержаны Программой повышения конкурентоспособности ведущих университетов РФ (постановление Правительства РФ № 211 от 16 марта 2013 г.)

A Survey of Experimental Research on Contests, All-Pay Auctions and Tournaments

Many economic, political and social environments can be described as contests in which agents exert costly efforts while competing over the distribution of a scarce resource. These environments have been studied using Tullock contests, all-pay auctions and rankorder tournaments. This survey provides a review of experimental research on these three canonical contests. First, we review studies investigating the basic structure of contests, including the contest success function, number of players and prizes, spillovers and externalities, heterogeneity, and incomplete information. Second, we discuss dynamic contests and multi-battle contests. Then we review research on sabotage, feedback, bias, collusion, alliances, and contests between groups, as well as real-effort and field experiments. Finally, we discuss applications of contests to the study of legal systems, political competition, war, conflict avoidance, sales, and charities, and suggest directions for future research. (author's abstract

Experimental Research on Contests

Costly competitions between economic agents are modeled as contests. Researchers use laboratory experiments to study contests and test comparative static predictions of contest theory. Commonly, researchers find that participants’ efforts are significantly higher than predicted by the standard Nash equilibrium. Despite overbidding, most comparative static predictions, such as the incentive effect, the size effect, the discouragement effect and others are supported in the laboratory. In addition, experimental studies examine various contest structures, including dynamic contests (such as multi-stage races, wars of attrition, tug-of-wars), multi-dimensional contests (such as Colonel Blotto games), and contests between groups. This article provides a short review of such studies