RWC Music Database: Music Genre Database and Musical Instrument Sound Database

This paper describes the design policy and specifications of the RWC Music Database, a copyright-cleared music database (DB) compiled specifically for research purposes. Shared DBs are common in other research fields and have made significant contributions to progress in those fields. The field of music information processing, however, has lacked a common DB of musical pieces or a large-scale DB of musical instrument sounds. We therefore recently constructed the RWC Music Database comprising four original component DBs: the Popular Music Database (100 pieces), Royalty-Free Music Database (15 pieces), Classical Music Database (50 pieces), and Jazz Music Database (50 pieces). In this paper we report the construction of two additional component DBs: the Music Genre Database (100 pieces) and Musical Instrument Sound Database (50 instruments). For all 315 musical pieces, we prepared original audio signals, corresponding standard MIDI files, and text files of lyrics (for songs). For all 50 instruments, we recorded individual sounds at half-tone intervals with several variations of playing styles, dynamics, instrument manufacturers, and musicians. It is our hope that our DB will make a significant contribution to future advances in the field of music information processing

Physicochemical Properties of the Mammalian Molecular Chaperone HSP60

The E. coli GroEL/GroES chaperonin complex acts as a folding cage by producing a bullet-like asymmetric complex, and GroEL exists as double rings regardless of the presence of adenosine triphosphate (ATP). Its mammalian chaperonin homolog, heat shock protein, HSP60, and co-chaperonin, HSP10, play an essential role in protein folding by capturing unfolded proteins in the HSP60/HSP10 complex. However, the structural transition in ATPase-dependent reaction cycle has remained unclear. We found nucleotide-dependent association and dissociation of the HSP60/HSP10 complex using various analytical techniques under near physiological conditions. Our results showed that HSP60 exist as a significant number of double-ring complexes (football- and bullet-type complexes) and a small number of single-ring complexes in the presence of ATP and HSP10. HSP10 binds to HSP60 in the presence of ATP, which increased the HSP60 double-ring formation. After ATP is hydrolyzed to Adenosine diphosphate (ADP), HSP60 released the HSP10 and the dissociation of the double-ring to single-rings occurred. These results indicated that HSP60/HSP10 undergoes an ATP-dependent transition between the single- and double-rings in their system that is highly distinctive from the GroEL/GroES system particularly in the manner of complex formation and the roles of ATP binding and hydrolysis in the reaction cycle

Common Variants in the COL4A4 Gene Confer Susceptibility to Lattice Degeneration of the Retina

Lattice degeneration of the retina is a vitreoretinal disorder characterized by a visible fundus lesion predisposing the patient to retinal tears and detachment. The etiology of this degeneration is still uncertain, but it is likely that both genetic and environmental factors play important roles in its development. To identify genetic susceptibility regions for lattice degeneration of the retina, we performed a genome-wide association study (GWAS) using a dense panel of 23,465 microsatellite markers covering the entire human genome. This GWAS in a Japanese cohort (294 patients with lattice degeneration and 294 controls) led to the identification of one microsatellite locus, D2S0276i, in the collagen type IV alpha 4 (COL4A4) gene on chromosome 2q36.3. To validate the significance of this observation, we evaluated the D2S0276i region in the GWAS cohort and in an independent Japanese cohort (280 patients and 314 controls) using D2S0276i and 47 single nucleotide polymorphisms covering the region. The strong associations were observed in D2S0276i and rs7558081 in the COL4A4 gene (Pc = 5.8×10−6, OR = 0.63 and Pc = 1.0×10−5, OR = 0.69 in a total of 574 patients and 608 controls, respectively). Our findings suggest that variants in the COL4A4 gene may contribute to the development of lattice degeneration of the retina

Prognostic significance of serum hepatocyte growth factor in clear cell renal cell carcinoma : comparison with serum vascular endothelial growth factor

No adequate serum predictive biomarker currently exists, which can identify the activity of renal cell carcinoma (RCC). We investigate the association of serum hepatocyte growth factor (HGF) and serum vascular endothelial growth factor (VEGF) levels with clinicopathologic parameters in untreated clear cell RCC patients. We measured serum levels of HGF and VEGF in 45 patients with untreated clear cell RCC and 45 healthy controls using an enzyme-linked immunosorbent assay (ELISA). Patients with clear cell RCC had significantly higher serum HGF and VEGF concentrations than healthy subjects : median, 1070.7 versus 728.3 pg/ml (p1150 pg/ml) was significantly reduced compared to patients with low serum HGF concentrations (p=0.0044). In patients with nuclear grade 2 or high stage RCC, the higher serum HGF group exhibited significantly lower cause-specific survival (p= 0.0087 and p<0.05, respectively). No significant difference was observed between serum VEGF levels and cause-specific survival rate. Serum HGF might be a diagnostic and prognostic indicator in clear cell RCC, especially for patients with grade 2 or high stage RCC

Impurity emission characteristics of long pulse discharges in Large Helical Device

Line spectra from intrinsic impurity ions have been monitored during the three kinds of long-pulse discharges (ICH, ECH, NBI). Constant emission from the iron impurity shows no preferential accumulation of iron ion during the long-pulse operations. Stable Doppler ion temperature has been also measured from Fe XX, C V and C III spectra

Recent Results from LHD Experiment with Emphasis on Relation to Theory from Experimentalist’s View

he Large Helical Device (LHD) has been extending an operational regime of net-current free plasmas towardsthe fusion relevant condition with taking advantage of a net current-free heliotron concept and employing a superconducting coil system. Heating capability has exceeded 10 MW and the central ion and electron temperatureshave reached 7 and 10 keV, respectively. The maximum value of β and pulse length have been extended to 3.2% and 150 s, respectively. Many encouraging physical findings have been obtained. Topics from recent experiments, which should be emphasized from the aspect of theoretical approaches, are reviewed. Those are (1) Prominent features in the inward shifted configuration, i.e., mitigation of an ideal interchange mode in the configuration with magnetic hill, and confinement improvement due to suppression of both anomalous and neoclassical transport, (2) Demonstration ofbifurcation of radial electric field and associated formation of an internal transport barrier, and (3) Dynamics of magnetic islands and clarification of the role of separatrix

Influence of Oil Field Discoveries on Sectoral Allocation of Government Expenditure

How do governments respond to an oil field discovery which can sometimes be worth as much as the nation’s gross domestic product? This paper studies the potential effect of oil field discoveries on sectoral allocation of government expenditure (“expenditure share”) both in the short run (i.e., before the production of oil from the discovered oil field) and in the long run (i.e., after the production of oil from the discovered oil field). I used econometrics methodologies of Difference-in-Differences to estimate the potential long-run effect as well as Event Study Design to examine the potential short-run effect on the expenditure share. Through examining, I found no evidence of the potential effects of oil field discoveries on government educational expenditure share, neither in the short-run nor in the long run. In terms of government military expenditure share, I did find evidence of such share increasing following an oil field discovery in the short run, yet I found no evidence of any potential effects in such share in the long run

INFLUENCE OF OIL FIELD DISCOVERIES ON SECTORAL ALLOCATION OF GOVERNMENT EXPENDITURE

45 pages. A thesis presented to the Department of Economics and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, 2021.How do governments respond to an oil field discovery which can sometimes be worth as much as the nation’s gross domestic product? This paper studies the potential effect of oil field discoveries on sectoral allocation of government expenditure (“expenditure share”) both in the short run (i.e., before the production of oil from the discovered oil field) and in the long run (i.e., after the production of oil from the discovered oil field). I used econometrics methodologies of Difference-in-Differences to estimate the potential long-run effect as well as Event Study Design to examine the potential short-run effect on the expenditure share. Through examining, I found no evidence of the potential effects of oil field discoveries on government educational expenditure share, neither in the short-run nor in the long run. In terms of government military expenditure share, I did find evidence of such share increasing following an oil field discovery in the short run, yet I found no evidence of any potential effects in such share in the long run