Isolated entrapment of the brachialis branch of the musculocutaneous nerve: a case report

Non peer reviewe

Advances in the Use of LTS and HTS SQUIDS in Electromagnetic NDE

Of the electromagnetic sensors currently under investigation for nondestructive evaluation (NDE), the superconducting quantum interference device (SQUID) arguably has the greatest potential. The characteristics [1] which make it suitable for eddy current NDE are: high sensitivity even in large ambient fields (detection of sub-nT signals); operation from very low frequencies (a few Hz or less) to very high frequencies (potentially MHz) permitting detection of surface and subsurface flaws; and high spatial resolution. Spatial resolution is related to the physical size of the device, which is often less than 1 mm square, even when the need to maintain its other properties is taken into account. This often allows the SQUID to be treated theoretically and practically as an ideal point sensor. However, it must be operated in a cryogenic environment: low temperature superconductor (LTS) SQUIDs need liquid helium and liquid nitrogen (LN2) is needed even for high temperature superconductor (HTS) SQUIDs. This makes it difficult to reduce the specimen-to-sensor stand-off below approximately 1 mm.</p

In Vitro Analysis of Integrated Global High-Resolution DNA Methylation Profiling with Genomic Imbalance and Gene Expression in Osteosarcoma

Genetic and epigenetic changes contribute to deregulation of gene expression and development of human cancer. Changes in DNA methylation are key epigenetic factors regulating gene expression and genomic stability. Recent progress in microarray technologies resulted in developments of high resolution platforms for profiling of genetic, epigenetic and gene expression changes. OS is a pediatric bone tumor with characteristically high level of numerical and structural chromosomal changes. Furthermore, little is known about DNA methylation changes in OS. Our objective was to develop an integrative approach for analysis of high-resolution epigenomic, genomic, and gene expression profiles in order to identify functional epi/genomic differences between OS cell lines and normal human osteoblasts. A combination of Affymetrix Promoter Tilling Arrays for DNA methylation, Agilent array-CGH platform for genomic imbalance and Affymetrix Gene 1.0 platform for gene expression analysis was used. As a result, an integrative high-resolution approach for interrogation of genome-wide tumour-specific changes in DNA methylation was developed. This approach was used to provide the first genomic DNA methylation maps, and to identify and validate genes with aberrant DNA methylation in OS cell lines. This first integrative analysis of global cancer-related changes in DNA methylation, genomic imbalance, and gene expression has provided comprehensive evidence of the cumulative roles of epigenetic and genetic mechanisms in deregulation of gene expression networks

Matrix Metalloproteinase Gene Delivery for Liver Fibrosis

The resolution of advanced liver fibrosis has been recently recognized to be possible, if the causative stimuli are successfully removed. However, whether complete resolution from cirrhosis, the end stage of liver fibrosis, can be achieved is still questionable. Delivery of interstitial collagenases, such as matrix metalloproteinase (MMP)-1, in the liver could be an attractive strategy to treat advanced hepatic fibrosis from the view point that the imbalance between too few interstitial collagenases and too many of their inhibitors is the main obstacle to the resolution from fibrosis. Remodeling of hepatic extracellular matrix by delivered interstitial collagenases also facilitates the disappearance of activated hepatic stellate cells, the main matrix-producing cells in the liver, and promotes the proliferation of hepatocytes. This review will focus on the impact of the gene delivery of MMPs for the treatment of advanced liver fibrosis while discussing other current therapeutic strategies for liver fibrosis, and on the need for the development of a safe and effective delivery system of MMPs

Standard of hygiene and immune adaptation in newborn infants

Peer reviewe

Science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems

We present the science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems, targeting an evolution in technology, that might lead to impacts and benefits reaching into most areas of society. This roadmap was developed within the framework of the European Graphene Flagship and outlines the main targets and research areas as best understood at the start of this ambitious project. We provide an overview of the key aspects of graphene and related materials (GRMs), ranging from fundamental research challenges to a variety of applications in a large number of sectors, highlighting the steps necessary to take GRMs from a state of raw potential to a point where they might revolutionize multiple industries. We also define an extensive list of acronyms in an effort to standardize the nomenclature in this emerging field.Peer ReviewedPostprint (published version

An analysis of the pull-out strength of 6 suture loop configurations in flexor tendons

10.1016/j.jhsa.2011.10.039Journal of Hand Surgery372217-223JHSU