ALMA imaging of SDP.81 - I. A pixelated reconstruction of the far-infrared continuum emission

We present a sub-50 pc-scale analysis of the gravitational lens system SDP.81 at redshift 3.042 using Atacama Large Millimetre/submillimetre Array (ALMA) science verification data. We model both the mass distribution of the gravitational lensing galaxy and the pixelated surface brightness distribution of the background source using a novel Bayesian technique that fits the data directly in visibility space. We find the 1 and 1.3 mm dust emission to be magnified by a factor of u_tot = 17.6+/-0.4, giving an intrinsic total star-formation rate of 315+/-60 M_sol/yr and a dust mass of 6.4+/-1.5*10^8 M_sol. The reconstructed dust emission is found to be non-uniform, but composed of multiple regions that are heated by both diffuse and strongly clumped star-formation. The highest surface brightness region is a ~1.9*0.7 kpc disk-like structure, whose small extent is consistent with a potential size-bias in gravitationally lensed starbursts. Although surrounded by extended star formation, with a density of 20-30+/-10 M_sol/yr/kpc^2, the disk contains three compact regions with densities that peak between 120-190+/-20 M_sol/yr/kpc^2. Such star-formation rate densities are below what is expected for Eddington-limited star-formation by a radiation pressure supported starburst. There is also a tentative variation in the spectral slope of the different star-forming regions, which is likely due to a change in the dust temperature and/or opacity across the source.Comment: MNRAS accepted 2015 April 1

ALMA imaging of SDP.81 - II. A pixelated reconstruction of the CO emission lines

We present a sub-100 pc-scale analysis of the CO molecular gas emission and kinematics of the gravitational lens system SDP.81 at redshift 3.042 using Atacama Large Millimetre/submillimetre Array (ALMA) science verification data and a visibility-plane lens reconstruction technique. We find clear evidence for an excitation dependent structure in the unlensed molecular gas distribution, with emission in CO (5-4) being significantly more diffuse and structured than in CO (8-7). The intrinsic line luminosity ratio is r_8-7/5-4 = 0.30 +/- 0.04, which is consistent with other low-excitation starbursts at z ~ 3. An analysis of the velocity fields shows evidence for a star-forming disk with multiple velocity components that is consistent with a merger/post-coalescence merger scenario, and a dynamical mass of M(< 1.56 kpc) = 1.6 +/- 0.6 x 10^10 M_sol . Source reconstructions from ALMA and the Hubble Space Telescope show that the stellar component is offset from the molecular gas and dust components. Together with Karl G. Jansky Very Large Array CO (1-0) data, they provide corroborative evidence for a complex ~2 kpc-scale starburst that is embedded within a larger ~15 kpc structure.Comment: MNRAS accepted, 6th July 201

First detection of the [OI] 63-um emission from a redshift 6 dusty galaxy

We report a ground-based detection of the [OI] 63-um line in a z=6.027 gravitationally lensed dusty star-forming galaxy (DSFG) G09.83808 using the APEX SEPIA 660 receiver, the first unambiguous detection of the [OI]63 line beyond redshift 3, and the first obtained from the ground. The [OI]63 line is robustly detected at 22$\pm$5 Jy km s$^{-1}$, corresponding to an intrinsic (de-lensed) luminosity of $(5.4\pm1.3)\times10^{9}$ L$_\odot$. With the [OI]63/[CII] luminosity ratio of 4, the [OI]63 line is the main coolant of the neutral gas in this galaxy, in agreement with model predictions. The high [OI]63 luminosity compensates for the pronounced [CII] deficit ([CII]/FIR$\simeq4\times10^{-4}$). Using photon-dominated region models, we derive a source-averaged gas density $n=10^{4.0}$ cm$^{-3}$, and far-UV field strength $G=10^4 G_0$, comparable to the z=2-4 DSFG population. If G09.83808 represents a typical high-redshift DSFG, the [OI]63 line from z=6 non-lensed DSFGs should be routinely detectable in ALMA Band 9 observations with $\sim$15 min on-source, opening a new window to study the properties of the earliest DSFGs.Comment: Submitted to ApJ

Intravenous Immunoglobulin for Hypogammaglobulinemia after Lung Transplantation: A Randomized Crossover Trial

Background We aimed to determine the effects of treatment with intravenous immunoglobulin on bacterial infections in patients with hypogammaglobulinemia (HGG) after lung transplantation. Methods We performed a randomized, double-blind, placebo-controlled two-period crossover trial of immune globulin intravenous (IVIG), 10% Purified (Gamunex, Bayer, Elkhart, IN) monthly in eleven adults who had undergone lung transplantation more than three months previously. We randomized study participants to three doses of IVIG (or 0.1% albumin solution (placebo)) given four weeks apart followed by a twelve week washout and then three doses of placebo (or IVIG). The primary outcome was the number of bacterial infections within each treatment period. Results IVIG had no effect on the number of bacterial infections during the treatment period (3 during IVIG and 1 during placebo; odds ratio 3.5, 95% confidence interval 0.4 to 27.6, p = 0.24). There were no effects on other infections, use of antibiotics, or lung function. IVIG significantly increased trough IgG levels at all time points (least square means, 765.3 mg/dl during IVIG and 486.3 mg/dl during placebo, p<0.001). Four serious adverse events (resulting in hospitalization) occurred during the treatment periods (3 during active treatment and 1 during the placebo period, p = 0.37). Chills, flushing, and nausea occurred during one infusion of IVIG. Conclusions Treatment with IVIG did not reduce the short-term risk of bacterial infection in patients with HGG after lung transplantation. The clinical efficacy of immunoglobulin supplementation in HGG related to lung transplantation over the long term or with recurrent infections is unknown