Hedge funds in emerging markets.

The paper outlines hedge fund activities in Asia and Hong Kong based on data from the Securities and Futures Commission in Hong Kong and private research fi rms specialised in hedge funds. In terms of growth, investment strategies, use of leverage and investor base, hedge funds in Hong Kong display characteristics similar to those of hedge funds investing in Asia’s emerging markets. Various financial sectors’ exposures to hedge funds remain small across the region and certain Asian markets are observed to be at the forefront of an international movement to enhance the oversight of hedge fund activities. However, the paper has highlighted the need for regulators to be aware of the potential concerns on hedge fund activities including the systemic risk on fi nancial stability, investor protection challenge and the risk of settlement failure. Finally, the paper proposes to enhance the effectiveness of regulating hedge fund activities in the region through continued vigilance on counterparty risk management, enhancement on collection of data, improvement on cross-border and cross-market sharing of information as well as regulatory cooperation.

Dear Prisoners-Be Prepared to be Gawkedat: Other Prisoners Watching You StripNaked is Reasonably Related to PenologicalInterests, or is it?

The Fourth Amendment states that citizens have the constitutional right to privacy, which includes being free from unreasonable searches. When citizens become prisoners, however, their rights, including their Fourth Amendment right against unreasonable searches, may be limited. For example, the Supreme Court upheld the constitutionality of blanket strip search policies in correctional institutions. The Supreme Court, however, cautioned that an unreasonably conducted strip search is unconstitutional if the strip search does not pass the reasonableness test. Because the Supreme Court has only reviewed cases involving privately conducted strip searches, the federal circuit and district courts have faced a new challenge: applying the reasonableness test to non-private, group strip searches. A strip search where a naked prisoner is forced to bend over and squat in front of not only the correctional officer conducting the strip search but also an audience of other naked prisoners is likely an extremely humiliating experience. Several courts agree that a wider audience enhances the invasion of privacy. What the courts have to determine regarding group strip searches is whether a legitimate penological interest of a correctional institution outweighs a prisoner\u27s privacy interests. This Comment will first examine the case law dealing with group strip searches. Next, this Comment will argue that courts rely too much on the correctional officers\u27 discretion when determining whether a group strip search advances a legitimate penological interest of the correctional institution. Finally, this Comment will analyze ways to combat the deference and recommend that the Supreme Court formally adopt a less invasive alternatives test when courts balance the needs of the correctional institution against the privacy interests of the prisoners

Development of an improved oxygen electrode for use in alkaline H2-O2 fuel cells Quarterly report, Apr. 1 - Jun. 30, 1967

Preparation of institial compounds of transition metals for hydrogen oxygen fuel cell cathode

Should the Psychiatrist Be Hospitalized?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68096/2/10.1177_002076407502100212.pd

“They told me all mothers have worries”, stillborn mother's experiences of having a ‘gut instinct’ that something is wrong in pregnancy: Findings from an international case–control study

Objective: To describe and explore 'gut instinct' that something was wrong in women who identified that they experienced gut instinct during pregnancy. Method: A case–control study utilising an international web-based questionnaire. Stillborn cases (n = 146) and liveborn controls (n = 234) answered the gut instinct question within 30 days of the pregnancy ending. Of those, 84 cases and 27 controls also provided qualitative comment data. Descriptive statistics were used for the question, with a fixed option and summative content analysis was used to analyse the comment data. Findings: In all, 110 (75%) of the stillborn cases answered "yes" to the gut instinct question vs only 28 (12%) of the controls who had a livebirth meaning the risk of stillbirth was 22.5 fold higher in those who experience "gut instinct" than in those who do not experience this feeling. Four themes were identified from the comment data namely: When the gut instinct occurred; How the gut instinct made the woman feel; Dreams and other related phenomena; Reassured by someone or something. Conclusions: Women who had a stillborn baby reported a "gut instinct" that something was wrong more frequently than mothers of a live born baby. Our findings may be influenced by recall negativity bias, and a prospective study is needed to confirm or refute our findings. The possibility that "maternal intuition" exists during pregnancy and responds to changes in fetal or placental health merits further exploration. Implications for practice: Maternity care providers should be alert to the woman when she expresses intuitive feelings, as well as asking her to report her concerns and act appropriately to assess and manage fetal wellbeing

Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis.

Acetyl-coenzyme A (acetyl-CoA) plays an important role in metabolism, gene expression, signaling, and other cellular processes via transfer of its acetyl group to proteins and metabolites. However, the synthesis and usage of acetyl-CoA in disease states such as cancer are poorly characterized. Here, we investigated global acetyl-CoA synthesis and protein acetylation in a mouse model and patient samples of hepatocellular carcinoma (HCC). Unexpectedly, we found that acetyl-CoA levels are decreased in HCC due to transcriptional downregulation of all six acetyl-CoA biosynthesis pathways. This led to hypo-acetylation specifically of non-histone proteins, including many enzymes in metabolic pathways. Importantly, repression of acetyl-CoA synthesis promoted oncogenic dedifferentiation and proliferation. Mechanistically, acetyl-CoA synthesis was repressed by the transcription factors TEAD2 and E2A, previously unknown to control acetyl-CoA synthesis. Knockdown of TEAD2 and E2A restored acetyl-CoA levels and inhibited tumor growth. Our findings causally link transcriptional reprogramming of acetyl-CoA metabolism, dedifferentiation, and cancer

Elevated arginine levels in liver tumors promote metabolic reprogramming and tumor growth

Arginine auxotropy, due to reduced expression of urea cycle genes, is common in cancer. However, little is known about the levels of arginine in these cancers. Here, we report that arginine levels are elevated in hepatocellular carcinoma (HCC) despite reduced expression of urea cycle enzymes. Liver tumors accumulate high levels specifically of arginine via increased uptake and, more importantly, via suppression of arginine-to-polyamine conversion due to reduced arginase 1 (ARG1) and agmatinase (AGMAT) expression. Furthermore, the high levels of arginine are required for tumor growth. Mechanistically, high levels of arginine promote tumorigenesis via transcriptional regulation of metabolic genes, including upregulation of asparagine synthetase (ASNS). ASNS-derived asparagine further enhances arginine uptake, creating a positive feedback loop to sustain high arginine levels and oncogenic metabolism. Thus, arginine is a novel second messenger-like molecule that reprograms metabolism to promote tumor growth