Psychological factors in retrograde amnesia: self-deception and a broken heart

We explored potential contributing psychological factors in a patient (‘XF’) with focal retrograde amnesia, within the framework proposed by Kopelman (2000). In particular, we investigated the psychological trait of self-enhancement. We constructed a self-report questionnaire measure of self-enhancement and compared XF’s score on this measure with the scores of 61 control participants. XF was found to have a significantly greater level of self-enhancement than the entire control group, and also than a smaller sample of age- and sex-matched controls. We propose that heightened self-enhancement may reflect a premorbid tendency that potentially predisposes individuals to develop retrograde amnesia

Bedrock Geology of the Osage 7.5\u27 Quadrangle, Mitchell County, Iowa

https://ir.uiowa.edu/igs_ofm/1115/thumbnail.jp

Bedrock Geology of the St. Ansgar 7.5\u27 Quadrangle, Mitchell County, Iowa

https://ir.uiowa.edu/igs_ofm/1113/thumbnail.jp

Bedrock Geology of the Mason City 7.5\u27 Quadrangle, Cerro Gordo County, Iowa

https://ir.uiowa.edu/igs_ofm/1109/thumbnail.jp

Surficial Geology of the Mason City 7.5\u27 Quadrangle, Cerro Gordo County, Iowa

https://ir.uiowa.edu/igs_ofm/1110/thumbnail.jp

Surficial Geology of the St. Ansgar 7.5\u27 Quadrangle, Mitchell County, Iowa

https://ir.uiowa.edu/igs_ofm/1114/thumbnail.jp

Surficial Geology of the Osage 7.5\u27 Quadrangle, Mitchell County, Iowa

https://ir.uiowa.edu/igs_ofm/1116/thumbnail.jp

NMR as a “gold standard” method in drug design and discovery

Studying disease models at the molecular level is vital for drug development in order to improve treatment and prevent a wide range of human pathologies. Microbial infections are still a major challenge because pathogens rapidly and continually evolve developing drug resistance. Cancer cells also change genetically, and current therapeutic techniques may be (or may become) ineffective in many cases. The pathology of many neurological diseases remains an enigma, and the exact etiology and underlying mechanisms are still largely unknown. Viral infections spread and develop much more quickly than does the corresponding research needed to prevent and combat these infections; the present and most relevant outbreak of SARS-CoV-2, which originated in Wuhan, China, illustrates the critical and immediate need to improve drug design and development techniques. Modern day drug discovery is a time-consuming, expensive process. Each new drug takes in excess of 10 years to develop and costs on average more than a billion US dollars. This demonstrates the need of a complete redesign or novel strategies. Nuclear Magnetic Resonance (NMR) has played a critical role in drug discovery ever since its introduction several decades ago. In just three decades, NMR has become a “gold standard” platform technology in medical and pharmacology studies. In this review, we present the major applications of NMR spectroscopy in medical drug discovery and development. The basic concepts, theories, and applications of the most commonly used NMR techniques are presented. We also summarize the advantages and limitations of the primary NMR methods in drug development

Recommendations and Standardization of Biomarker Quantification Using NMR-Based Metabolomics with Particular Focus on Urinary Analysis

[Image: see text] NMR-based metabolomics has shown considerable promise in disease diagnosis and biomarker discovery because it allows one to nondestructively identify and quantify large numbers of novel metabolite biomarkers in both biofluids and tissues. Precise metabolite quantification is a prerequisite to move any chemical biomarker or biomarker panel from the lab to the clinic. Among the biofluids commonly used for disease diagnosis and prognosis, urine has several advantages. It is abundant, sterile, and easily obtained, needs little sample preparation, and does not require invasive medical procedures for collection. Furthermore, urine captures and concentrates many “unwanted” or “undesirable” compounds throughout the body, providing a rich source of potentially useful disease biomarkers; however, incredible variation in urine chemical concentrations makes analysis of urine and identification of useful urinary biomarkers by NMR challenging. We discuss a number of the most significant issues regarding NMR-based urinary metabolomics with specific emphasis on metabolite quantification for disease biomarker applications and propose data collection and instrumental recommendations regarding NMR pulse sequences, acceptable acquisition parameter ranges, relaxation effects on quantitation, proper handling of instrumental differences, sample preparation, and biomarker assessment

Analytic atheism : A cross-culturally weak and fickle phenomenon?

Religious belief is a topic of longstanding interest to psychological science, but the psychology of religious disbelief is a relative newcomer. One prominently discussed model is analytic atheism, wherein cognitive reflection, as measured with the Cognitive Reflection Test, overrides religious intuitions and instruction. Consistent with this model, performance-based measures of cognitive reflection predict religious disbelief in WEIRD (Western, Educated, Industrialized, Rich, & Democratic) samples. However, the generality of analytic atheism remains unknown. Drawing on a large global sample (N = 3461) from 13 religiously, demographically, and culturally diverse societies, we find that analytic atheism as usually assessed is in fact quite fickle cross-culturally, appearing robustly only in aggregate analyses and in three individual countries. The results provide additional evidence for culture's effects on core beliefs.Peer reviewe