An Experiment in Scaling Impact: Assessing the Growth Capital Aggregation Pilot

This report presents an assessment of the Growth Capital Aggregation Pilot. It was commissioned by the Edna McConnell Clark Foundation, founder and lead investor of the grantmaking initiative.Starting in 2000, The Edna McConnell Clark Foundation (Clark) adopted an investment approach to grantmaking that focused on providing growth capital to youth-serving organizations with demonstrated commitments to evaluation and measurable outcomes. For grantees, the strategy meant larger, longer-term, unrestricted investments, complemented by extensive access to consulting and technical assistance to strengthen their organizations.This approach helped Clark grantees across the portfolio increase the numbers of youth they served (for example, by 18 percent between 2005 and 2006) and achieve annual revenue gains (averaging 19 percent over the four years prior to the founding of GCAP). At the same time, the Foundation concluded that more capital would be required if its grantees and other promising youth-serving organizations were to realize their ultimate scale and sustainability potential

Utilizing Strategic Culture as a Tool to Tailor U.S. Deterrence Policy Towards Iran

The geostrategic environment since the end of the Cold War has drastically changed the way United States (U.S.) policymakers develop strategies to combat a wide range of hostile threats facing the country, especially in the field of the deterrence of weapons of mass destruction (WMDs). Iran is such an actor, who poses one of the greater proliferation threats in the world and continues to commit hostile actions in the Middle East. In this post-Cold War environment, it is imperative that the United States develop a tailored deterrence strategy to meet this challenge. Past deterrence strategies popular during the bipolar era of the Cold War focused on the idea of a “rational actor,” one in which an adversary theoretically would similarly make decisions to how U.S. leadership thinks about the values of a cost-benefit analysis of any strategic action. However, with the emergence of new and asymmetric threats, it has become apparent that not all actors in the world think in the same way as U.S. leaders. Starting in the Cold War era, the concept of strategic culture emerged, which sought to understand the cultural drivers behind state behavior. Strategic culture is a field of research which gives insight into another culture, and how their values, norms, and perceptions shape the way that they view rational decision making on a cost-benefit analysis. This field of study can provide explanations for decisions that others might make; how/when to go to war, what constitutes the rationality to pursue or use WMDs, and what values they hold which are exploitable. By using strategic culture as a tool to tailor a deterrence strategy, the United States will be better able to formulate policy to contain, deter, and defeat adversaries. This report will use the Islamic Republic of Iran as a case study to present its threat to U.S. strategic objectives, explain how strategic culture can be used to understand threats from Iran, and then assess its strategic culture to use in the formulation of a tailored deterrence policy against the Islamic Republic

The Edna McConnell Clark Foundation's Youth Development Fund: Results and Lessons from the First Ten Years

In 1999, the Edna McConnell Clark Foundation (EMCF) began an experiment that would ultimately reinvent its grantmaking. Starting with three grantees, it tested an approach for improving the life prospects of disadvantaged young people by investing heavily in the capacity of nonprofits to "scale up" programs of proven effectiveness. For the past 10 years, conducting more than 150 confidential interviews with leaders of more than 40 grantees, we have provided the Foundation ongoing feedback about the effects -- intended and unintended -- of its grantmaking. For this paper, we returned to our archive of interviews and examined the Foundation's own performance data to consider two questions:Have the Foundation's grantees moved the needle -- with greater scale and impact -- in improving the life prospects of vulnerable youth? What lessons can be drawn from EMCF's experiences -- positive and negative -- to inform others in the field?This paper has three parts: 1 An overview of the grantmaking strategy the Foundation adopted in 1999; 2 A summary of grantee progress in achieving the scale and impact that are the goals of EMCF's grants; and 3 Lessons and reflections on key aspects of the Foundation's approach

An Engineering Learning Community To Promote Retention And Graduation Of At-Risk Engineering Students

Retention and graduation rates for engineering disciplines are significantly lower than desired, and research literature offers many possible causes. Engineering learning communities provide the opportunity to study relationships among specific causes and to develop and evaluate activities designed to lessen their impact. This paper details an engineering learning community created to combat three common threats to academic success of engineering students: financial difficulties, math deficiencies, and the lack of a supportive engineering culture. The project tracks participants in the learning community from first year through graduation to assess the effectiveness of its activities in improving retention and graduation rates. Scholarships were made available to address the financial difficulties; tutors, mentors, study groups, and a “freshman-to-sophomore bridge” summer program were provided to address math deficiencies; cohort engineering courses, active learning techniques, required group meetings, required group study sessions, dedicated study space, and dedicated faculty advisors were used to promote a sense of community. Quantitative retention and graduation rates for the cohort are compared to other engineering groups at the same institution. Qualitative results collected via student surveys and interviews, and lessons learned by project administrators are also presented. Retention and graduation rates of the cohort are better than those of comparable groups at the same institution. Graduation rates based upon freshman math placement are also higher than comparable groups.

POPULATION DYNAMICS OF THE WANDERING ALBATROSS DIOMEDEA EXULANS AT MARION ISLAND: LONGLINE FISHING AND ENVIRONMENTAL INFLUENCES

The subantarctic Prince Edward Islands (Marion and Prince Edward) support the largest breeding population of the Vulnerable wandering albatross Diomedea exulans. The number of birds breeding at Marion Island has fluctuated over the past three decades apparently as a result of both real changes in the size of the population and changes in the proportion of the population that attempts to breed in a given year. Changes in several demographic parameters that appear to be influenced by both environmental and anthropogenic effects are described. From 1994–2001, the proportion of first-time breeders in the population was positively correlated with the maximum ENSO (Ni&#241o 3) index, whereas from 1984–2000 the annual survival rates of breeding adults were negatively correlated with Japanese pelagic longline fishing effort in the southern Indian Ocean. Adult survival rates were significantly correlated with those on neighbouring Possession Island, Crozet Islands, but differed from those at South Georgia, suggesting common factors operating at an ocean-basin scale. The average survival rate of adult females was lower than that of males. Males who lost partners took 40% longer than females to find a new mate, suggesting a male-biased population. Survival rates of juvenile males and females did not differ. The age distribution of first-time breeders shifted progressively towards younger birds during the 1990s. Higher than expected survival rates of breeding adults during the late 1990s may be linked to large amounts of supplementary food being made available by the initiation of a longline fishery for Patagonian toothfish Dissostichus eleginoides close to the islands at this time. Overall, breeding success was better than recorded at other localities, indicating that breeding conditions at Marion Island were comparatively favourable. The early implementation of both international and national conservation initiatives to reduce the impact of longline fishing on this species and improve its conservation status is encouraged.Afr. J. mar. Sci. 25: 503–51

Prospective Phase II trial of drug-eluting bead chemoembolization for liver transplant candidates with hepatocellular carcinoma and marginal hepatic reserve.

Purpose: To determine whether chemoembolization using drug-eluting beads (DEB-TACE) is safe and effective for liver transplantation candidates with liver-limited hepatocellular carcinoma (HCC) without vascular invasion and baseline hepatic dysfunction. Materials and methods: Seventeen adult liver transplantation candidates (median age 66 years, range 58-73 years; 13 men) with HCC were treated with DEB-TACE as a part of Stage 1 of a prospective single-institution Phase II trial. All patients had marginal hepatic reserve based on at least one of the following criteria: ascites (n=14), bilirubin between 3 and 6 mg/dL (n=5), AST 5-10 times upper normal limit (n=1), INR between 1.6 and 2.5 (n=4), portal vein thrombosis (n=2), and/or portosystemic shunt (n=2). Primary study objectives were safety and best observed radiographic response. Results: Thirty-seven DEB-TACE procedures were performed. Objective response rate and disease control rate were 63% and 88%, respectively. HCC progression was observed in 12 patients. Median time to progression was 5.6 months (range 0.9-13.6 months). Within 1 month following DEB-TACE, 13 patients (76%) developed grade 3 or 4 AE attributable to the procedure. Four patients (all within Milan Criteria) were transplanted (2.7-6.9 months after DEB-TACE), and 12 patients died (1.8-32 months after DEB-TACE). All deaths were due to liver failure that was either unrelated to HCC (n=5), in the setting of metastatic HCC (n=5), or in the setting of locally advanced HCC (n=2). Mortality rate at 1 month was 0%. Conclusions: DEB-TACE achieves tumor responses but carries a high risk of hepatotoxicity for liver transplant candidates with HCC and marginal hepatic reserve