3,255 research outputs found

    Go & Make Disciples: The Biblical Foundation for Discipleship in the Way of Jesus

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    What are Jesus’ foundational teachings that lay the groundwork for discipleship in the church today? Within this paper, I will seek to work through the initial section of Jesus’ Sermon on the Mount to distill the essential theological lessons of Christ on discipleship. After introducing some important cultural realities concerning the state of discipleship in the church today, Matthew 5 will be thoroughly engaged. Beginning with a discussion on cultural, literary, and theological backgrounds, the passage will be broken down section by section to discern key truths expressed for the modern church. The paper will conclude with further reflection questions for church leaders as they seek to practically apply this teaching in their setting

    A Comprehensive Systems Biology Approach to Studying Zika Virus

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    Zika virus (ZIKV) is responsible for an ongoing and intensifying epidemic in the Western Hemisphere. We examined the complete predicted proteomes, glycomes, and selectomes of 33 ZIKV strains representing temporally diverse members of the African lineage, the Asian lineage, and the current outbreak in the Americas. Derivation of the complete selectome is an 'omics' approach to identify distinct evolutionary pressures acting on different features of an organism. Employment of the M8 model did not show evidence of global diversifying selection acting on the ZIKV polyprotein; however, a mixed effect model of evolution showed strong evidence (P<0.05) for episodic diversifying selection acting on specific sites. Single nucleotide polymorphisms (SNPs) were predictably frequent across strains relative to the derived consensus sequence. None of the 9 published detection procedures utilize targets that share 100% identity across the 33 strains examined, indicating that ZIKV escape from molecular detection is predictable. The predicted O-linked glycome showed marked diversity across strains; however, the N-linked glycome was highly stable. All Asian and American strains examined were predicted to include glycosylation of E protein ASN154, a modification proposed to mediate neurotropism, whereas the modification was not predicted for African strains. SNP diversity, episodic diversifying selection, and differential glycosylation, particularly of ASN154, may have major biological implications for ZIKV disease. Taken together, the systems biology perspective of ZIKV indicates: a.) The recently emergent Asian/American N-glycotype is mediating the new and emerging neuropathogenic potential of ZIKV; and b.) further divergence at specific sites is predictable as endemnicity is established in the Americas

    Diffuse-Illumination Systems for Growing Plants

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    Agriculture in both terrestrial and space-controlled environments relies heavily on artificial illumination for efficient photosynthesis. Plant-growth illumination systems require high photon flux in the spectral range corresponding with plant photosynthetic active radiation (PAR) (400 700 nm), high spatial uniformity to promote uniform growth, and high energy efficiency to minimize electricity usage. The proposed plant-growth system takes advantage of the highly diffuse reflective surfaces on the interior of a sphere, hemisphere, or other nearly enclosed structure that is coated with highly reflective materials. This type of surface and structure uniformly mixes discrete light sources to produce highly uniform illumination. Multiple reflections from within the domelike structures are exploited to obtain diffuse illumination, which promotes the efficient reuse of photons that have not yet been absorbed by plants. The highly reflective surfaces encourage only the plant tissue (placed inside the sphere or enclosure) to absorb the light. Discrete light sources, such as light emitting diodes (LEDs), are typically used because of their high efficiency, wavelength selection, and electronically dimmable properties. The light sources are arranged to minimize shadowing and to improve uniformity. Different wavelengths of LEDs (typically blue, green, and red) are used for photosynthesis. Wavelengths outside the PAR range can be added for plant diagnostics or for growth regulatio

    Control Design for a Generic Commercial Aircraft Engine

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    This paper describes the control algorithms and control design process for a generic commercial aircraft engine simulation of a 40,000 lb thrust class, two spool, high bypass ratio turbofan engine. The aircraft engine is a complex nonlinear system designed to operate over an extreme range of environmental conditions, at temperatures from approximately -60 to 120+ F, and at altitudes from below sea level to 40,000 ft, posing multiple control design constraints. The objective of this paper is to provide the reader an overview of the control design process, design considerations, and justifications as to why the particular architecture and limits have been chosen. The controller architecture contains a gain-scheduled Proportional Integral controller along with logic to protect the aircraft engine from exceeding any limits. Simulation results illustrate that the closed loop system meets the Federal Aviation Administration s thrust response requirement

    Reducing Conservatism in Aircraft Engine Response Using Conditionally Active Min-Max Limit Regulators

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    Current aircraft engine control logic uses a Min-Max control selection structure to prevent the engine from exceeding any safety or operational limits during transients due to throttle commands. This structure is inherently conservative and produces transient responses that are slower than necessary. In order to utilize the existing safety margins more effectively, a modification to this architecture is proposed, referred to as a Conditionally Active (CA) limit regulator. This concept uses the existing Min-Max architecture with the modification that limit regulators are active only when the operating point is close to a particular limit. This paper explores the use of CA limit regulators using a publicly available commercial aircraft engine simulation. The improvement in thrust response while maintaining all necessary safety limits is demonstrated in a number of cases

    Characterization of Pontibacter altruii, sp. nov., isolated from a human blood culture

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    The genus Pontibacter is a recent addition to the family Cytophagaceae, phylum Bacteroidetes. Previous reports of its cultivation and molecular detection are from a variety of environmental sources, including marine and desert habitats. We report the first description of a Pontibacter sp., which was initially identified as Elizabethkingia meningoseptica, isolated from a human clinical specimen. On the basis of 16S rRNA gene sequence, unique mass spectral profile and phenotypic characterization, this isolate represents a novel species within the genus Pontibacter that has been named Pontibacter altruii, sp. nov., strain Grand Forks

    A3_9 Driving up the Eiffel Tower

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    This paper discusses how far up the Eiffel Tower a car is able to drive, depending on the friction force that the car is able to generate. With a coefficient of static friction between rubber and solids given as between 1.0 and 4.0 it is calculated that the angle for which a car would no longer be able to drive up the tower is between 45° and 76°. It is then calculated that for the Eiffel Tower the car would not be able to drive up a surface of coefficient of friction 1.0 but for the surface of coefficient of friction 4.0 the car would be able to make it to the first platform at a height of 57m

    A3_8 If You Want Blood (You've Got It)

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     This paper explores the possibility of estimating the density of red blood cells in a one millimetre section of vein in a human adult by measuring the temperature of the blood. The results show that this novel method gives an answer that is three orders of magnitude too large and so would be inappropriate to use in practise

    A3_1 Can't Find Your Atlas?

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    In Greek Mythology the Titan Atlas was condemned by Zeus to bear the weight of the sky upon his shoulders as punishment for his rebellion. This paper explores just how titanic in stature a humanoid Atlas would have to be to perform such a task
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