485 research outputs found
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Ventilation system consequence calculations to support salt well pumping single-shell tank 241-A-101
This document presents the radiological dose and toxicological exposure calculations for an accident scenario involved with the ventilation system used to support salt well pumping single-shell tank 241-A-101. This tank has been listed on the Hydrogen Watch List
Appraisal, Agency and Atypicality: Evidence from Manufactured Homes
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73056/1/j.1540-6229.2005.00128.x.pd
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Transformation by the R Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation
The identification of succinate dehydrogenase (SDH), fumarate hydratase (FH), and isocitrate dehydrogenase (IDH) mutations in human cancers has rekindled the idea that altered cellular metabolism can transform cells. Inactivating SDH and FH mutations cause the accumulation of succinate and fumarate, respectively, which can inhibit 2-oxoglutarate (2-OG)-dependent enzymes, including the EglN prolyl 4-hydroxylases that mark the HIF transcription factor for polyubiquitylation and proteasomal degradation 1. Inappropriate HIF activation is suspected of contributing to the pathogenesis of SDH-defective and FH-defective tumors but can suppress tumor growth in some other contexts. IDH1 and IDH2, which catalyze the interconversion of isocitrate and 2-OG, are frequently mutated in human brain tumors and leukemias. The resulting mutants display the neomorphic ability to convert 2-OG to the R-enantiomer of 2-hydroxyglutarate (R-2HG) 2, 3. Here we show that R-2HG, but not S-2HG, stimulates EglN activity leading to diminished HIF levels, which enhances the proliferation and soft agar growth of human astrocytes
Milagrito: a TeV air-shower array
Milagrito, a large, covered water-Cherenkov detector, was the world's first
air-shower-particle detector sensitive to cosmic gamma rays below 1 TeV. It
served as a prototype for the Milagro detector and operated from February 1997
to May 1998. This paper gives a description of Milagrito, a summary of the
operating experience, and early results that demonstrate the capabilities of
this technique.Comment: 38 pages including 24 figure
Application of whey of Mozzarella di Bufala Campana fermented by lactic acid bacteria as a bread biopreservative agent
A total of nine isolated lactic acid bacteria (LAB) from tomato and sourdough with antifungal activity were employed to revaluate the whey of Mozzarella di Bufala through the fermentation process for 72 h at 37 °C. Then, the fermented whey (BWF) was characterised and used as biopreservative in bread formulation. L. plantarum TR7 and L. plantarum TR2 strains showed average lactic acid concentration in BWF of 13.8 g L 1. Also, the bread volatile organic compounds (VOC) analysis showed an increase in hexanal, benzeneacetaldehyde, benzaldehyde and pyrazine tetramethyl when using BWF as ingredient. Moreover, the DPPH-inhibitory activity of bread with BWF extract also reflected a 33% rise in comparison with control bread. The application of BWF as a biopreservation agent in bread showed an increase in shelf life compared with bread with 0.3% calcium propionate and bread control for 2 and 15 days, respectively. BWF can be used as an interesting biopreservation strategy of bread
About Bianchi I with VSL
In this paper we study how to attack, through different techniques, a perfect
fluid Bianchi I model with variable G,c and Lambda, but taking into account the
effects of a -variable into the curvature tensor. We study the model under
the assumption,div(T)=0. These tactics are: Lie groups method (LM), imposing a
particular symmetry, self-similarity (SS), matter collineations (MC) and
kinematical self-similarity (KSS). We compare both tactics since they are quite
similar (symmetry principles). We arrive to the conclusion that the LM is too
restrictive and brings us to get only the flat FRW solution. The SS, MC and KSS
approaches bring us to obtain all the quantities depending on \int c(t)dt.
Therefore, in order to study their behavior we impose some physical
restrictions like for example the condition q<0 (accelerating universe). In
this way we find that is a growing time function and Lambda is a decreasing
time function whose sing depends on the equation of state, w, while the
exponents of the scale factor must satisfy the conditions
and
, i.e. for all equation of state relaxing in this way the
Kasner conditions. The behavior of depends on two parameters, the equation
of state and a parameter that controls the behavior of
therefore may be growing or decreasing.We also show that through
the Lie method, there is no difference between to study the field equations
under the assumption of a var affecting to the curvature tensor which the
other one where it is not considered such effects.Nevertheless, it is essential
to consider such effects in the cases studied under the SS, MC, and KSS
hypotheses.Comment: 29 pages, Revtex4, Accepted for publication in Astrophysics & Space
Scienc
Disrupting the Ethical Imperatives of âJuniorâ Critical Qualitative Scholars in the Era of Conservative Modernization
In this article, we wrestle with the core issue of how early career researchers translate central tenets and core concepts of critical theory and critical methodology into their research practice. By way of creative representation, we draw from bell hooks and Cornel Westâs (1991) written rendition of their verbal dialogue in Breaking Bread: Insurgent Black Intellectual Life. Their hope was to offer the book in a dialogic format in such a way that mirrored the synergy in their verbal discussions as friends and intellectual colleagues. In a similar vein, we hope to share with readers the synergy and depth of the narratives that have transpired during our ongoing discussions on the important topic of critical praxis as part of a collaborative research group called the Disruptive Dialogue Project (Gildersleeve, Kuntz, Pasque & Carducci, 2010; Kuntz, Pasque, Carducci, & Gildersleeve, 2009).Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline
Origins of the Ambient Solar Wind: Implications for Space Weather
The Sun's outer atmosphere is heated to temperatures of millions of degrees,
and solar plasma flows out into interplanetary space at supersonic speeds. This
paper reviews our current understanding of these interrelated problems: coronal
heating and the acceleration of the ambient solar wind. We also discuss where
the community stands in its ability to forecast how variations in the solar
wind (i.e., fast and slow wind streams) impact the Earth. Although the last few
decades have seen significant progress in observations and modeling, we still
do not have a complete understanding of the relevant physical processes, nor do
we have a quantitatively precise census of which coronal structures contribute
to specific types of solar wind. Fast streams are known to be connected to the
central regions of large coronal holes. Slow streams, however, appear to come
from a wide range of sources, including streamers, pseudostreamers, coronal
loops, active regions, and coronal hole boundaries. Complicating our
understanding even more is the fact that processes such as turbulence,
stream-stream interactions, and Coulomb collisions can make it difficult to
unambiguously map a parcel measured at 1 AU back down to its coronal source. We
also review recent progress -- in theoretical modeling, observational data
analysis, and forecasting techniques that sit at the interface between data and
theory -- that gives us hope that the above problems are indeed solvable.Comment: Accepted for publication in Space Science Reviews. Special issue
connected with a 2016 ISSI workshop on "The Scientific Foundations of Space
Weather." 44 pages, 9 figure
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