5 research outputs found

    Proceedings of the 2016 Childhood Arthritis and Rheumatology Research Alliance (CARRA) Scientific Meeting

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    Does Clientelism Hinder Progressive Social Policy in Latin America?

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    Contains fulltext : 238531.pdf (Publisher’s version ) (Closed access)12 januari 202

    Political Representation, Executives, and Political Parties Survey: Data from Expert Surveys in 18 Latin American Countries, 2018-2019. PREPPS Latam V2

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    Our 2018/2019 Latin American expert survey expanded and combined previous efforts of measuring policy positioning (Wiesehomeier and Benoit, 2009) and democratic linkage mechanisms (Kitschelt 2013). Questions on policy positions included the general left-right dimension, the economic left-right, social policies, redistribution, foreign policy, and environmental policy, among others. Furthermore the survey collected information on conditional exchange and party organization. The data therefore will allow for a comprehensive comparative assessment of policy dimensions for a large number of parties and presidents across 18 Latin American countries in conjunction with mechanisms of accountability and modes of competition

    International Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis

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    Objective: To develop a standardized steroid dosing regimen (SSR) for physicians treating childhood-onset systemic lupus erythematosus (SLE) complicated by lupus nephritis (LN), using consensus formation methodology. Methods: Parameters influencing corticosteroid (CS) dosing were identified (step 1). Data from children with proliferative LN were used to generate patient profiles (step 2). Physicians rated changes in renal and extrarenal childhood-onset SLE activity between 2 consecutive visits and proposed CS dosing (step 3). The SSR was developed using patient profile ratings (step 4), with refinements achieved in a physician focus group (step 5). A second type of patient profile describing the course of childhood-onset SLE for ≥4 months since kidney biopsy was rated to validate the SSR-recommended oral and intravenous (IV) CS dosages (step 6). Patient profile adjudication was based on majority ratings for both renal and extrarenal disease courses, and consensus level was set at 80%. Results: Degree of proteinuria, estimated glomerular filtration rate, changes in renal and extrarenal disease activity, and time since kidney biopsy influenced CS dosing (steps 1 and 2). Considering these parameters in 5,056 patient profile ratings from 103 raters, and renal and extrarenal course definitions, CS dosing rules of the SSR were developed (steps 3–5). Validation of the SSR for up to 6 months post–kidney biopsy was achieved with 1,838 patient profile ratings from 60 raters who achieved consensus for oral and IV CS dosage in accordance with the SSR (step 6). Conclusion: The SSR represents an international consensus on CS dosing for use in patients with childhood-onset SLE and proliferative LN. The SSR is anticipated to be used for clinical care and to standardize CS dosage during clinical trials. © 2021, American College of Rheumatolog
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