Housework Metaphor for Gambling Public Health Action: An Indigenous Perspective

Housework,thosedutiesdoneathomeorinone’scommunitytokeepandcleanand tidy, is used in this paper as a metaphor for Māori involvement in gambling public health action in New Zealand. For over a decade Māori have been developing their own voice, public health actions, gambling services, research and workforce development initiatives to address gambling related harm at a whānau, community, local government, national and now international level. Involvement in gambling public health action has required Māori to utilise our Treaty of Waitangi and now international indigenous peoples’ rights to ensuring legislation and host responsibility requirements are met at all levels in New Zealand society. Housework which is a demanding task required to be done on a regular basis Māori have found never ends. To address this situation Māori have moved their focus to those organisations which have duty of care responsibilities defined under the Gambling Act 2003 and local government responsbilities to involve them in housework duties. By working together, Māori have assumed this will assist in reducing gambling related harm. Efforts made by Māori have been shared at our first interna- tional indigenous gambling conference held in New Zealand to warn our local Pacific nation neighbours of the risks associated with expansion of gambling

The Iowa Homemaker vol.3, no.7

Table of Contents Home Economics Cleans House – Division Ready for New Year by Anna E. Richardson, page 1 Storing the Winter’s Supply of Vitamines by C. L. Fitch, page 2 First Hand Acquaintance With Tokyo’s Earthquake by Katherine Cranor, page 3 Hurrah for the Pumpkin Pie by Ruth Elaine Wilson, page 4 Choosing the Fall Hat by Florence Faust, page 5 Who is Responsible for the Child? by An “Old – Maid Aunt”, page 6 A Review of Farm Meats by Viola M. Bell, page 6 Color Hints From Gay October by Ruth Spencer, page 7 Paying Homage to the King of Fruits by Jeanette Beyer, page 8 Sheppard-Towner Bill by Lois Miller Herd, page 9 Buttons and _______ Buttons by Esther Ellen Rayburn, page 9 Candy Popularity by Esther Ellen Rayburn, page 13 Before the Bar of Science by Eda Lord Murphy, page 15 Gingered Pears by Elizabeth Storm, page 1

Genetic diversity fuels gene discovery for tobacco and alcohol use

Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury(1-4). These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries(5). Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction.Peer reviewe

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead