Fuentes de financiamiento y su impacto en el crecimiento empresarial en los comerciantes en mercado “La Parada”, Talara, 2023

El presente estudio tiene la finalidad de indagar sobre las fuentes de financiamiento y su impacto en el crecimiento comercial de los comerciantes del mercado modelo “La Parada”, Talara, 2023. La investigación adopta un enfoque correlacional de tipo no experimental y de corte transversal. La población de interés incluye a 31 administradores y/o propietarios de negocios textiles que operan en el mercado mencionado. La muestra, seleccionada mediante el método censal, abarca el 100% de la población y se les administró un cuestionario basado en la escala Likert. Los datos recolectados fueron analizados utilizando el software SPSS v27 y se evaluó la confiabilidad mediante el coeficiente Alfa de Cronbach. Los resultados, obtenidos a través del estadístico de Chi cuadrado de Pearson, arrojaron un valor de 3,858 con una significancia bilateral asintótica de 0,428, lo cual supera el umbral crítico de 0,005. En consecuencia, se acepta la hipótesis nula, concluyendo que las fuentes de financiamiento no tienen un impacto significativo en el crecimiento comercial de los comerciantes del mercado modelo "La Parada" en Talara durante el año 2023

Gestión de biblioteca y redes académicas de portales Públicas, en Lima, 2020

La finalidad del estudio fue indagar la relación que existe entre la gestión de la biblioteca y redes académica de portales públicas en Lima, 2020. Es una investigación cuantitativa de nivel básico descriptivo, no experimental de corte transversal y retrospectivo. La muestra fue elegida a través del método no probabilístico aplicado a una muestra de 35 bibliotecólogos que laboran en sector público, en Lima en el 2020, a la cual se aplicó el instrumento del cuestionario en forma de la escala Likert. Los datos recopilados se han procesado en el software SPSS v25 y se determinó la confiabilidad alta mediante el coeficiente del Alfa de Crombach. Los resultados muestran la existencia de una relación directa del nivel de correlación entre la variable gestión de biblioteca y las redes académicas de portales pública en Lima en el año 2020, es de 0,699 y existe un nivel de correlación con p valor a ,000 (p < 0,05). Por consiguiente, se rechaza la hipótesis nula y se acepta la hipótesis alterna. Los encuestados calificaron de regular con indicador de 40%, frente a una 34,3% de calificación deficiente y un 25,7% a la gestión de biblioteca y con respecto a las redes académicas de portales públicas mostraron una calificación regular con un indicador de 37,14%, frente a la apreciación de calificación porcentual deficiente con 34,29% y de eficiente con un indicador de 28,57%

Disentangling the multigenic and pleiotropic nature of molecular function

Background: Biological processes at the molecular level are usually represented by molecular interaction networks. Function is organised and modularity identified based on network topology, however, this approach often fails to account for the dynamic and multifunctional nature of molecular components. For example, a molecule engaging in spatially or temporally independent functions may be inappropriately clustered into a single functional module. To capture biologically meaningful sets of interacting molecules, we use experimentally defined pathways as spatial/temporal units of molecular activity. Results: We defined functional profiles of Saccharomyces cerevisiae based on a minimal set of Gene Ontology terms sufficient to represent each pathway's genes. The Gene Ontology terms were used to annotate 271 pathways, accounting for pathway multi-functionality and gene pleiotropy. Pathways were then arranged into a network, linked by shared functionality. Of the genes in our data set, 44% appeared in multiple pathways performing a diverse set of functions. Linking pathways by overlapping functionality revealed a modular network with energy metabolism forming a sparse centre, surrounded by several denser clusters comprised of regulatory and metabolic pathways. Signalling pathways formed a relatively discrete cluster connected to the centre of the network. Genetic interactions were enriched within the clusters of pathways by a factor of 5.5, confirming the organisation of our pathway network is biologically significant. Conclusions: Our representation of molecular function according to pathway relationships enables analysis of gene/protein activity in the context of specific functional roles, as an alternative to typical molecule-centric graph-based methods. The pathway network demonstrates the cooperation of multiple pathways to perform biological processes and organises pathways into functionally related clusters with interdependent outcomes

PT-112 Induces Mitochondrial Stress and Immunogenic Cell Death, Targeting Tumor Cells with Mitochondrial Deficiencies

PT-112 is a novel pyrophosphate–platinum conjugate, with clinical activity reported in advanced pretreated solid tumors. While PT-112 has been shown to induce robust immunogenic cell death (ICD) in vivo but only minimally bind DNA, the molecular mechanism underlying PT-112 target disruption in cancer cells is still under elucidation. The murine L929 in vitro system was used to test whether differential metabolic status alters PT-112’s effects, including cell cytotoxicity. The results showed that tumor cells presenting mutations in mitochondrial DNA (mtDNA) (L929dt and L929dt cybrid cells) and reliant on glycolysis for survival were more sensitive to cell death induced by PT-112 compared to the parental and cybrid cells with an intact oxidative phosphorylation (OXPHOS) pathway (L929 and dtL929 cybrid cells). The type of cell death induced by PT-112 did not follow the classical apoptotic pathway: the general caspase inhibitor Z-VAD-fmk did not inhibit PT-112-induced cell death, alone or in combination with the necroptosis inhibitor necrostatin-1. Interestingly, PT-112 initiated autophagy in all cell lines, though this process was not complete. Autophagy is known to be associated with an integrated stress response in cancer cells and with subsequent ICD. PT-112 also induced a massive accumulation of mitochondrial reactive oxygen species, as well as changes in mitochondrial polarization—only in the sensitive cells harboring mitochondrial dysfunction—along with calreticulin cell-surface exposure consistent with ICD. PT-112 substantially reduced the amount of mitochondrial CoQ10 in L929 cells, while the basal CoQ10 levels were below our detection limits in L929dt cells, suggesting a potential relationship between a low basal level of CoQ10 and PT-112 sensitivity. Finally, the expression of HIF-1α was much higher in cells sensitive to PT-112 compared to cells with an intact OXPHOS pathway, suggesting potential clinical applications

Gene-obesogenic environment interactions in the UK Biobank study

This is the final version of the article. Available from the publisher via the DOI in this record.BACKGROUND: Previous studies have suggested that modern obesogenic environments accentuate the genetic risk of obesity. However, these studies have proven controversial as to which, if any, measures of the environment accentuate genetic susceptibility to high body mass index (BMI). METHODS: We used up to 120 000 adults from the UK Biobank study to test the hypothesis that high-risk obesogenic environments and behaviours accentuate genetic susceptibility to obesity. We used BMI as the outcome and a 69-variant genetic risk score (GRS) for obesity and 12 measures of the obesogenic environment as exposures. These measures included Townsend deprivation index (TDI) as a measure of socio-economic position, TV watching, a 'Westernized' diet and physical activity. We performed several negative control tests, including randomly selecting groups of different average BMIs, using a simulated environment and including sun-protection use as an environment. RESULTS: We found gene-environment interactions with TDI (Pinteraction = 3 × 10(-10)), self-reported TV watching (Pinteraction = 7 × 10(-5)) and self-reported physical activity (Pinteraction = 5 × 10(-6)). Within the group of 50% living in the most relatively deprived situations, carrying 10 additional BMI-raising alleles was associated with approximately 3.8 kg extra weight in someone 1.73 m tall. In contrast, within the group of 50% living in the least deprivation, carrying 10 additional BMI-raising alleles was associated with approximately 2.9 kg extra weight. The interactions were weaker, but present, with the negative controls, including sun-protection use, indicating that residual confounding is likely. CONCLUSIONS: Our findings suggest that the obesogenic environment accentuates the risk of obesity in genetically susceptible adults. Of the factors we tested, relative social deprivation best captures the aspects of the obesogenic environment responsible.J.T. is funded by a Diabetes Research and Wellness Foundation Fellowship. S.E.J. is funded by the Medical Research Council (grant: MR/M005070/1). M.A.T., M.N.W. and A.M. are supported by the Wellcome Trust Institutional Strategic Support Award (WT097835MF). A.R.W., H.Y. and T.M.F. are supported by the European Research Council grant: 323195:SZ-245 50371- GLUCOSEGENES-FP7-IDEAS-ERC. R.M.F. is a Sir Henry Dale Fellow (Wellcome Trust and Royal Society grant: 104150/Z/14/Z). R.B. is funded by the Wellcome Trust and Royal Society grant: 104150/Z/14/Z. R.M.A is supported by the Wellcome Trust Institutional Strategic Support Award (WT105618MA). Z.K. is funded by Swiss National Science Foundation (31003A-143914). The funders had no influence on study design, data collection and analysis, decision to publish or preparation of the manuscript. The data reported in this paper are available via application directly to the UK Biobank

Comisión de Promoción y Desarrollo de la Investigación Acta 8

1- Revisión de las fortalezas, oportunidades y debilidades identificadas sobre pertinencia institucional local/global. 2- Trabajo en comisión para listar las amenazas / problemas / riesgos. 3- Definir objetivos y posibles líneas de acción.Fil: Ames, Cecilia. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Ateca, María Rosa. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; Argentina.Fil: Fernández, Alicia Ruth. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Giacomelli, Carla. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Guido, Mario Eduardo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Herz, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Monti, Gustavo Alberto. Facultad de Matemática, Astronomía, Física y Computación. Universidad Nacional de Córdoba; Argentina.Fil: Recalde, María Luisa. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades; Argentina.Fil: Recalde, María Luisa. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Rueda, Nelly Elena María. Universidad Nacional de Córdoba. Facultad de Lenguas; Argentina.Fil: Strumia, Miriam. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina

Comisión de Promoción y Desarrollo de la Investigación Informe 8

Octava dimensión de análisis transversal: Desarrollo, aplicación efectiva de los recursos humanos, organizacionales, técnicos, materiales y financieros.Fil: Ames, Cecilia. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Ateca, María Rosa. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; Argentina.Fil: Fernández, Alicia Ruth. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Giacomelli, Carla. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Guido, Mario Eduardo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Herz, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Monti, Gustavo Alberto. Facultad de Matemática, Astronomía, Física y Computación. Universidad Nacional de Córdoba; Argentina.Fil: Recalde, María Luisa. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades; Argentina.Fil: Recalde, María Luisa. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Rueda, Nelly Elena María. Universidad Nacional de Córdoba. Facultad de Lenguas; Argentina.Fil: Strumia, Miriam. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina

The case for strategic international alliances to harness nutritional genomics for public and personal health

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countrie

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder