Deep and early molecular response induced by nilotinb in a newly diagnosed patient with chronic myeloid leukemia (CML)

We report a case of a patient with chronic myeloid leukemia diagnosed in January 2012 and treated with nilotinib 600 mg/die as first line therapy. Patient obtained a complete hematologic response (CHR) and improvement of splenomegaly in 2 weeks. In three months the patient obtained complete cytogenetic response (CCR) and an important transcript level reduction (less than 1%). According to the international recommendations, molecular analysis was performed every three months in a LABNET network laboratory. Treatment was never interrupted or reduced due to any adverse event. After 9 months patient achieved a major molecular response (MMR) and during evaluation a MR4 has been documented

Nilotinib therapy after resistance and intolerance to imatinib in CML patient with trisomy of the chromosome 8

In this article is presented the case of a 30-year-old woman with chronic myeloid leukaemia (CML) treated with imatinib for 15 months, and then with nilotinib as second-line therapy. Two episodes of grade 3 neutropenia, the detection of the trisomy of chromosome 8 and the failed achievement of a major molecular response (MMolR) in 15 months led to the switch to nilotinib. With nilotinib the patient obtained the lack of the genetic anomaly in 3 months and a complete molecular response (CMolR) in 6 months, all confirmed at 9 months. No haematologic or extra-haematologic adverse events were detected with this second-line agent

Football players and asset manipulation: the management of football transfers in Italian Serie A

Research question: We consider player trading as one of the distinctive features of football clubs’ business models and how these models have been influenced since the implementation of Financial Fair Play (FFP). Considering the Italian financial and economic context in the football sector, we investigate whether Serie A football clubs adopt earnings manipulation as a result of trading players’ economic rights. Research methods: The empirical analysis includes the football clubs competing in the Italian Serie A from 2005 to 2018. Using an unbalanced panel dataset composed of 275 club-year observations (38 different clubs), our estimations are run by using fixed effects OLS models. Clubs’ net capital income from sales of football players is used as a proxy of earning manipulation. We control for clubs’ football performance, size and reputation. Results and Findings: By applying Bartov’s model based on asset sales, our results confirm the adoption of asset manipulation behaviours in the football industry, wherein players’ economic rights sales are a preponderant financial item affecting economic performance. Specifically, net income from trading players is significant and positively linked with Serie A clubs’ profitability, while leverage is significant after the introduction of FFP and especially for the most prominent Serie A clubs. Implications: Our results confirm that Italian Serie A has been chronically dependent on player trading to maintain their financial sustainability. UEFA’s regulations could be assessed and modified to enable them to prevent and reveal the real activities and dynamics behind the player transfer market (profit smoothing behaviours)

Non random distribution of genomic features in breakpoint regions involved in chronic myeloid leukemia cases with variant t(9;22) or additional chromosomal rearrangements

<p>Abstract</p> <p>Background</p> <p>The t(9;22)(q34;q11), generating the Philadelphia (Ph) chromosome, is found in more than 90% of patients with chronic myeloid leukemia (CML). As a result of the translocation, the 3' portion of the <it>ABL1 </it>oncogene is transposed from 9q34 to the 5' portion of the <it>BCR </it>gene on chromosome 22 to form the <it>BCR</it>/<it>ABL1 </it>fusion gene. At diagnosis, in 5-10% of CML patients the Ph chromosome is derived from variant translocations other than the standard t(9;22).</p> <p>Results</p> <p>We report a molecular cytogenetic study of 452 consecutive CML patients at diagnosis, that revealed 50 cases identifying three main subgroups: i) cases with variant chromosomal rearrangements other than the classic t(9;22)(q34;q11) (9.5%); ii) cases with cryptic insertions of <it>ABL1 </it>into <it>BCR</it>, or vice versa (1.3%); iii) cases bearing additional chromosomal rearrangements concomitant to the t(9;22) (1.1%). For each cytogenetic group, the mechanism at the basis of the rearrangement is discussed.</p> <p>All breakpoints on other chromosomes involved in variant t(9;22) and in additional rearrangements have been characterized for the first time by Fluorescence In Situ Hybridization (FISH) experiments and bioinformatic analyses. This study revealed a high content of <it>Alu </it>repeats, genes density, GC frequency, and miRNAs in the great majority of the analyzed breakpoints.</p> <p>Conclusions</p> <p>Taken together with literature data about CML with variant t(9;22), our findings identified several new cytogenetic breakpoints as hotspots for recombination, demonstrating that the involvement of chromosomes other than 9 and 22 is not a random event but could depend on specific genomic features. The presence of several genes and/or miRNAs at the identified breakpoints suggests their potential involvement in the CML pathogenesis.</p

Recovery of CMV-Specific CD8+ T Cells and Tregs after Allogeneic Peripheral Blood Stem Cell Transplantation

n/

SARS-CoV-2 Infection Incidence and Outcome Before and After Full Vaccination in Patients With Monoclonal Gammopathy of Undetermined Significance

N

Cardiovascular toxicity in patients with chronic myeloid leukemia treated with second-generation tyrosine kinase inhibitors in the real-life practice: Identification of risk factors and the role of prophylaxis

No abstract availabl

Optimisation Study of the Fabry-Pérot Optical Cavity for the MARIX/BRIXS Compton X-Ray Source

We present the study of the optimization of the optical cavity parameters, in order to maximise the flux of scattered photons in the Compton scattering process. In the optimisation, we compensate the losses of the photon number due to the elliptical shape of the laser pulse in optical cavity with a high focusing electron beam