813 research outputs found

    Beyond “Psychic Income”: An Exploration of Interventions to Address Work-Life Imbalances, Burnout, and Precarity in Contemporary Nonprofit Work

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    Nonprofit scholars and practitioners alike adhere to a long-held assumption that nonprofit work is, and will remain, inherently meaningful work. The long-term marketization of the nonprofit sector coupled with the influence of the COVID-19 pandemic has undercut this narrative. Our research on meaningful nonprofit work indicates that while many nonprofit workers do find their work meaningful, pay, flexibility, and work/life balance are increasingly important to them. This commentary suggests that nonprofit leaders can no longer presume that workers motivated by prosocial values will seek out and stay with nonprofit work, satisfied with the “psychic income” that comes from doing good work. Nonprofits must be managed and led differently such that they center workers’ contemporary needs and desires. Organizational and public policy initiatives around pay equity and flexible work can support such a transition for the nonprofit sector

    Universality and Scaling at the Onset of Quantum Black Hole Formation

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    In certain two-dimensional models, collapsing matter forms a black hole if and only if the incoming energy flux exceeds the Hawking radiation rate. Near the critical threshold, the black hole mass is given by a universal formula in terms of the distance from criticality, and there exists a scaling solution describing the formation and evaporation of an arbitrarily small black hole.Comment: 9 pages, 3 figures (uuencoded

    Investigation of Magnesium Cation-proton Exchange with Transmembrane Electrostatically Localized Protons (TELP) at a Liquid-membrane Interface: Fundamental to Bioenergetics

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    The Lee transmembrane electrostatic proton localization (TELP) theory is a revolutionary scientific theory that has successfully explained decades long-standing quandary in the field of bioenergetics in regards to ATP synthesis in biological systems, specifically alkalophilic bacteria. This study provides experimental support for the TELP theory by further demonstrating evidence of a localized proton layer existing at the liquid-membrane interface in a simulated biological membrane apparatus. Whilst monovalent cations have been studied extensively, divalent cation exchange has not been studied experimentally. A previous study determined equilibrium constant for Na+ and K+ to exchange with localized H+ layer to be (5.07 ± 0.46) x 10-8 and (6.93 ± 0.91) x 10-8 respectively. We discovered that an equilibrium exchange occurs at 0.85 mM Mg2+ concentration. The findings here contributed to the successful determination of the equilibrium constant between Mg2+ and the localized H+ layer to be (1.56 ± 0.46) x 10-5. The equilibrium constant, much smaller than one, thus provides support for Lee’s TELP model since so many more Mg2+ in the bulk liquid phase that are required to even partially delocalize just a single H+ at the liquid-membrane interface. These results are relevant to further understand how water can act as a proton conductor for proton coupling energy transduction and the implications of different biological organisms’ salinity tolerance.https://digitalcommons.odu.edu/gradposters2022_sciences/1012/thumbnail.jp

    Numerical Analysis of Black Hole Evaporation

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    Black hole formation/evaporation in two-dimensional dilaton gravity can be described, in the limit where the number NN of matter fields becomes large, by a set of second-order partial differential equations. In this paper we solve these equations numerically. It is shown that, contrary to some previous suggestions, black holes evaporate completely a finite time after formation. A boundary condition is required to evolve the system beyond the naked singularity at the evaporation endpoint. It is argued that this may be naturally chosen so as to restore the system to the vacuum. The analysis also applies to the low-energy scattering of SS-wave fermions by four-dimensional extremal, magnetic, dilatonic black holes.Comment: 10 pages, 9 figures in separate uuencoded fil

    Quantum Theories of Dilaton Gravity

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    Quantization of two-dimensional dilaton gravity coupled to conformal matter is investigated. Working in conformal gauge about a fixed background metric, the theory may be viewed as a sigma model whose target space is parameterized by the dilaton ϕ\phi and conformal factor ρ\rho. A precise connection is given between the constraint that the theory be independent of the background metric and conformal invariance of the resulting sigma model. Although the action is renormalizable, new coupling constants must be specified at each order in perturbation theory in order to determine the quantum theory. These constants may be viewed as initial data for the beta function equations. It is argued that not all choices of this data correspond to physically sensible theories of gravity, and physically motivated constraints on the data are discussed. In particular a recently constructed subclass of initial data which reduces the full quantum theory to a soluble Liouville-like theory has energies unbounded from below and thus is unphysical. Possibilities for modifying this construction so as to avoid this difficulty are briefly discussed.Comment: 20 pages (Major additions made, including 5 pages on the relation between conformal invariance and background independence.

    Measurement of Magnetic Flux in a Hall Thruster for Comparison to Mathematical Model

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    As part of the early development of a Hall-effect thruster, a type of advanced electric propulsion system, a prototype thruster body was built for the purpose of experimentation. To be as close as possible to reality, the prototype was designed and built under the assumption that it would be fireable. As such, it is equipped with a ceramic discharge chamber, as well as with customized electromagnets which use 28 AWG magnet wire and 1010 steel for the cores. The field is measured using Hall sensors for comparison with a mathematical model of the field. Physical systems and mathematical models can be used to iteratively improve one another, so this experiment serves as a beginning to the much larger project of fully developing a fully functional thruster system. Results of this experiment will affect the progress of development, either requiring system modifications or allowing for further system design

    A study of size-dependent properties of MoS2 monolayer nanoflakes using density-functional theory

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    Novel physical phenomena emerge in ultra-small sized nanomaterials. We study the limiting small-size-dependent properties of MoS2 monolayer rhombic nanoflakes using density-functional theory on structures of size up to Mo35S70 (1.74 nm). We investigate the structural and electronic properties as functions of the lateral size of the nanoflakes, finding zigzag is the most stable edge configuration, and that increasing size is accompanied by greater stability. We also investigate passivation of the structures to explore realistic settings, finding increased HOMO-LUMO gaps and energetic stability. Understanding the size-dependent properties will inform efforts to engineer electronic structures at the nano-scale

    Dissection of Besnoitia besnoiti intermediate host life cycle stages: From morphology to gene expression.

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    Cyst-forming Apicomplexa (CFA) of the Sarcocystidae have a ubiquitous presence as pathogens of humans and farm animals transmitted through the food chain between hosts with few notable exceptions. The defining hallmark of this family of obligate intracellular protists consists of their ability to remain for very long periods as infectious tissue cysts in chronically infected intermediate hosts. Nevertheless, each closely related species has evolved unique strategies to maintain distinct reservoirs on global scales and ensuring efficient transmission to definitive hosts as well as between intermediate hosts. Here, we present an in-depth comparative mRNA expression analysis of the tachyzoite and bradyzoite stages of Besnoitia besnoiti strain Lisbon14 isolated from an infected farm animal based on its annotated genome sequence. The B. besnoiti genome is highly syntenic with that of other CFA and also retains the capacity to encode a large majority of known and inferred factors essential for completing a sexual cycle in a yet unknown definitive host. This work introduces Besnoitia besnoiti as a new model for comparative biology of coccidian tissue cysts which can be readily obtained in high purity. This model provides a framework for addressing fundamental questions about the evolution of tissue cysts and the biology of this pharmacologically intractable infectious parasite stage

    Dissection of Besnoitia besnoiti intermediate host life cycle stages: From morphology to gene expression

    Full text link
    Cyst-forming Apicomplexa (CFA) of the Sarcocystidae have a ubiquitous presence as pathogens of humans and farm animals transmitted through the food chain between hosts with few notable exceptions. The defining hallmark of this family of obligate intracellular protists consists of their ability to remain for very long periods as infectious tissue cysts in chronically infected intermediate hosts. Nevertheless, each closely related species has evolved unique strategies to maintain distinct reservoirs on global scales and ensuring efficient transmission to definitive hosts as well as between intermediate hosts. Here, we present an in-depth comparative mRNA expression analysis of the tachyzoite and bradyzoite stages of Besnoitia besnoiti strain Lisbon14 isolated from an infected farm animal based on its annotated genome sequence. The B. besnoiti genome is highly syntenic with that of other CFA and also retains the capacity to encode a large majority of known and inferred factors essential for completing a sexual cycle in a yet unknown definitive host. This work introduces Besnoitia besnoiti as a new model for comparative biology of coccidian tissue cysts which can be readily obtained in high purity. This model provides a framework for addressing fundamental questions about the evolution of tissue cysts and the biology of this pharmacologically intractable infectious parasite stage
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