Counting the costs of crime in Australia: a 2011 estimate

This report estimates the costs of crime for the calendar year 2011. Executive summary This report seeks to estimate how much crime costs the Australian economy by calculating the number of crimes that come to the attention of the authorities and, using crime victimisation survey data, the number of crimes that are not recorded officially. A dollar figure is then calculated for each estimated crime event and an indication given of the total cost of each specific crime type in terms of actual loss, intangible losses, loss of output caused through the criminal conduct and other related costs such as medical expenses, where relevant. Added to these costs are the costs of preventing and responding to crime in the community including the costs of maintaining the criminal justice system agencies of police, prosecution, courts and correctional agencies, as well as a proportion of the costs of Australian and state and territory government agencies that have crime-related functions. Finally, a deduction is made for the value of property recovered in the case of property crime, as well as the amount of funds recovered from criminals under federal, state and territory proceeds of crime legislation. More detailed information about how each of these estimates was derived is provided in the main body of the report. Official attention paid to specific crime types, particularly drug-related crime and organised crime, affects both the reporting rate and also the cost of policing and correctional responses. In this sense, individual crime type costs and prevention and response costs are not mutually exclusive. Arguably, as individual crime types attract more attention, reporting rates increase and prevention and control of the crimes in question are seen as being deserving of increased resource

Naming and graphing entrepreneurial and community based agriculture linkages

The project sought to document food- and community-related information available in southwest Iowa counties and to connect various sectors that might work together to add value to local foods and increase food commerce

A decentralised, multidisciplinary model of care facilitates treatment of hepatitis C in regional Australia

Objectives: Direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) has excellent cure rates and minimal side effects. Despite the high burden of disease, strategies to ultimately eradicate HCV are being developed. However, the delivery of care in regional settings is challenging and the efficacy of decentralised models of care is incompletely defined. Methods: A prospective cohort study of patients whose treatment was initiated or supervised by Cairns Hospital, a tertiary hospital which provides services to a culturally diverse population across a 380,748 km2 area in regional Australia. Patients` demographics, clinical features, DAA regimens and outcomes were recorded and correlated with their ensuing clinical course. Results: Over 22 months, 734 patients were prescribed DAA therapy for HCV. No patients were prescribed interferon. Sofosbuvir/ledipasvir (n=371, 50.5%) and sofosbuvir/daclatasvir (n=287, 39.1%) were the most commonly prescribed regimens. No patients ceased treatment due to adverse effects. There were 612/734 (83.4%) patients with complete results, with 575 (94%) cured. At the end of the study period, there were 50 (6.8%) patients lost to follow-up and 72 (9.8%) awaiting SVR12 testing. The presence of cirrhosis (n=147/612, 24.1%) did not impact significantly on SVR12 rates, this being achieved in 136/147 (92.5%) cirrhotic patients versus 440/465 (94.6%) in non-cirrhotic patients (p=0.34). Treatment-experienced patients (95/612, 18.3%) were more likely to be non-responders than treatment-naive patients (10/95 (10.5%) versus 26/517 (5%), p=0.04). Strategies to facilitate treatment included a dedicated clinical nurse consultant, education to primary health care providers, specialist outreach clinics to regional communities and shared care with general practitioners. SVR12 rates were similar amongst gastroenterologists (283/306, 92.5%), general practitioners (152/161, 94.4%), sexual health physicians (104/106, 98.1%) and other prescribers (37/39, 94.9%). Conclusions: This study confirms that decentralised, multidisciplinary models of care can provide HCV treatment in regional and remote settings with excellent outcomes

Mechanistic within-host models of the asexual; Plasmodium falciparum; infection: a review and analytical assessment

BACKGROUND: Malaria blood-stage infection length and intensity are important drivers of disease and transmission; however, the underlying mechanisms of parasite growth and the host's immune response during infection remain largely unknown. Over the last 30 years, several mechanistic mathematical models of malaria parasite within-host dynamics have been published and used in malaria transmission models. METHODS: Mechanistic within-host models of parasite dynamics were identified through a review of published literature. For a subset of these, model code was reproduced and descriptive statistics compared between the models using fitted data. Through simulation and model analysis, key features of the models were compared, including assumptions on growth, immune response components, variant switching mechanisms, and inter-individual variability. RESULTS: The assessed within-host malaria models generally replicate infection dynamics in malaria-naive individuals. However, there are substantial differences between the model dynamics after disease onset, and models do not always reproduce late infection parasitaemia data used for calibration of the within host infections. Models have attempted to capture the considerable variability in parasite dynamics between individuals by including stochastic parasite multiplication rates; variant switching dynamics leading to immune escape; variable effects of the host immune responses; or via probabilistic events. For models that capture realistic length of infections, model representations of innate immunity explain early peaks in infection density that cause clinical symptoms, and model representations of antibody immune responses control the length of infection. Models differed in their assumptions concerning variant switching dynamics, reflecting uncertainty in the underlying mechanisms of variant switching revealed by recent clinical data during early infection. Overall, given the scarce availability of the biological evidence there is limited support for complex models. CONCLUSIONS: This study suggests that much of the inter-individual variability observed in clinical malaria infections has traditionally been attributed in models to random variability, rather than mechanistic disease dynamics. Thus, it is proposed that newly developed models should assume simple immune dynamics that minimally capture mechanistic understandings and avoid over-parameterization and large stochasticity which inaccurately represent unknown disease mechanisms

Assessment of energy intake and energy expenditure of male adolescent academy-level soccer players during a competitive week

This study investigated the energy intake and expenditure of professional adolescent academy-level soccer players during a competitive week. Over a seven day period that included four training days, two rest days and a match day, energy intake (self-reported weighed food diary and 24-h recall) and expenditure (tri-axial accelerometry) were recorded in 10 male players from a professional English Premier League club. The mean macronutrient composition of the dietary intake was 318 ± 24 g·day−1 (5.6 ± 0.4 g·kg−1 BM) carbohydrate, 86 ± 10 g·day−1 (1.5 ± 0.2 g·kg−1 BM) protein and 70 ± 7 g·day−1 (1.2 ± 0.1 g·kg−1 BM) fats, representing 55% ± 3%, 16% ± 1%, and 29% ± 2% of mean daily energy intake respectively. A mean daily energy deficit of −1302 ± 1662 kJ (p = 0.035) was observed between energy intake (9395 ± 1344 kJ) and energy expenditure (10679 ± 1026 kJ). Match days (−2278 ± 2307 kJ, p = 0.012) and heavy training days (−2114 ± 2257 kJ, p = 0.016) elicited the greatest deficits between intake and expenditure. In conclusion, the mean daily energy intake of professional adolescent academy-level soccer players was lower than the energy expended during a competitive week. The magnitudes of these deficits were greatest on match and heavy training days. These findings may have both short and long term implications on the performance and physical development of adolescent soccer players

Faint satellite population of the NGC-3175 Group – a Local Group analogue

In this paper, we identify and study the properties of low-mass dwarf satellites of a nearby Local Group analogue – the NGC-3175 galaxy group with the goal of investigating the nature of the lowest mass galaxies and the ‘Missing Satellites’ problem. Deep imaging of nearby groups such as NGC-3175 is one of the only ways to probe these low-mass galaxies which are important for problems in cosmology, dark matter and galaxy formation. We discover 553 candidate dwarf galaxies in the group, the vast majority of which have never been studied before. We obtained R and B band imaging, with the European Southern Observatory 2.2 m, around the central ∼500 kpc region of NGC-3175, allowing us to detect galaxies down to ∼23 mag (MB ∼ −7.7 mag) in the B band. In the absence of spectroscopic information, dwarf members and likely background galaxies are separated using colour, morphology, and surface brightness criteria. We compare the observed size, surface brightness, and mass scaling relations to literature data. The luminosity function with a faint end slope of α = −1.31, is steeper than that observed in the Local Group. In comparison with simulations, we find that our observations are between a pure Λ cold dark matter model and one involving baryonic effects, removing the apparent problem of finding too few satellites as seen around the Milky Way

Engaging Opportunities: Connecting young people with contemporary research and researchers

This is the final report for ‘Engaging Opportunities’, an RCUK-funded School-University Partnership between the Open University and the Denbigh Teaching School Alliance. Informed by action research, this four-year project was designed to create structured, strategic, sustainable and equitable mechanisms for effective school-university engagement with research. The report describes an evidence-based strategy designed to embed school-university engagement with research within the University’s strategic planning for research and the operational practices of researchers. Through the early stages of our partnership we noted a lack of suitable planning tools that work for researchers, teachers and students. We therefore introduced a flexible and adaptable framework of four types of activity—open lectures, open dialogues, open inquiry and open creativity—combined with an upstream approach to planning based on a set of six principles. A sub-set of these activities were evaluated through a combination of surveys, interviews and interventions. In conclusion, we argue that institutional and professional cultures can be resistant to the prospect of fully embedding school-university engagement with research in a structured, strategic and sustainable manner, and offer suggestions for how this context could and should be changed