Comparison of Energies Required to Densify Liquefiable Soil

The objective of the study presented herein is to compare the energy required to densify loose, liquefiable sand by various techniques and the energy required to liquefy the soil by earthquake shaking. The states-of-practice for performing remedial ground densification and evaluating earthquake liquefaction potential of loose saturated sands have evolved relatively independently of each other. This is in spite of the fact that the inducement of liquefaction is typically requisite for remedial ground densification of sands. Using the energy required to induce liquefaction as a common metric, simple calculations are presented for estimating the mechanical energy required to densify a unit volume of clean, loose, saturated sand using deep dynamic compaction, vibrocompaction, and explosive compaction. These computed energies are compared with that required to induce liquefaction during an earthquake per the Green- Mitchell energy based liquefaction evaluation procedure. The comparison highlights the importance of the efficiency of the process by which the energy is imparted to the soil and the importance of the mode of dissipation of the imparted energy (e.g., breaking down of initial soil structure, ramming soil particles into denser packing, and/or radiating away from the treatment zone). Additionally, the comparison lays the groundwork for incorporating the vast knowledge from fundamental studies on earthquake induced liquefaction into design procedures for remedial ground densification

Robust designs for Poisson regression models

We consider the problem of how to construct robust designs for Poisson regression models. An analytical expression is derived for robust designs for first-order Poisson regression models where uncertainty exists in the prior parameter estimates. Given certain constraints in the methodology, it may be necessary to extend the robust designs for implementation in practical experiments. With these extensions, our methodology constructs designs which perform similarly, in terms of estimation, to current techniques, and offers the solution in a more timely manner. We further apply this analytic result to cases where uncertainty exists in the linear predictor. The application of this methodology to practical design problems such as screening experiments is explored. Given the minimal prior knowledge that is usually available when conducting such experiments, it is recommended to derive designs robust across a variety of systems. However, incorporating such uncertainty into the design process can be a computationally intense exercise. Hence, our analytic approach is explored as an alternative

Representation of Probability Density Functions from Orbit Determination using the Particle Filter

Statistical orbit determination enables us to obtain estimates of the state and the statistical information of its region of uncertainty. In order to obtain an accurate representation of the probability density function (PDF) that incorporates higher order statistical information, we propose the use of nonlinear estimation methods such as the Particle Filter. The Particle Filter (PF) is capable of providing a PDF representation of the state estimates whose accuracy is dependent on the number of particles or samples used. For this method to be applicable to real case scenarios, we need a way of accurately representing the PDF in a compressed manner with little information loss. Hence we propose using the Independent Component Analysis (ICA) as a non-Gaussian dimensional reduction method that is capable of maintaining higher order statistical information obtained using the PF. Methods such as the Principal Component Analysis (PCA) are based on utilizing up to second order statistics, hence will not suffice in maintaining maximum information content. Both the PCA and the ICA are applied to two scenarios that involve a highly eccentric orbit with a lower apriori uncertainty covariance and a less eccentric orbit with a higher a priori uncertainty covariance, to illustrate the capability of the ICA in relation to the PCA

The Feasibility of a Using a Smart Button Mobile Health System to Self-Track Medication Adherence and Deliver Tailored Short Message Service Text Message Feedback

BACKGROUND: As many as 50% of people experience medication nonadherence, yet studies for detecting nonadherence and delivering real-time interventions to improve adherence are lacking. Mobile health (mHealth) technologies show promise to track and support medication adherence. OBJECTIVE: The study aimed to evaluate the feasibility and acceptability of using an mHealth system for medication adherence tracking and intervention delivery. The mHealth system comprises a smart button device to self-track medication taking, a companion smartphone app, a computer algorithm used to determine adherence and then deliver a standard or tailored SMS (short message service) text message on the basis of timing of medication taking. Standard SMS text messages indicated that the smartphone app registered the button press, whereas tailored SMS text messages encouraged habit formation and systems thinking on the basis of the timing the medications were taken. METHODS: A convenience sample of 5 adults with chronic kidney disease (CKD), who were prescribed antihypertensive medication, participated in a 52-day longitudinal study. The study was conducted in 3 phases, with a standard SMS text message sent in phases 1 (study days 1-14) and 3 (study days 46-52) and tailored SMS text messages sent during phase 2 (study days 15-45) in response to participant medication self-tracking. Medication adherence was measured using: (1) the smart button and (2) electronic medication monitoring caps. Concordance between these 2 methods was evaluated using percentage of measurements made on the same day and occurring within ±5 min of one another. Acceptability was evaluated using qualitative feedback from participants. RESULTS: A total of 5 patients with CKD, stages 1-4, were enrolled in the study, with the majority being men (60%), white (80%), and Hispanic/Latino (40%) of middle age (52.6 years, SD 22.49; range 20-70). The mHealth system was successfully initiated in the clinic setting for all enrolled participants. Of the expected 260 data points, 36.5% (n=95) were recorded with the smart button and 76.2% (n=198) with electronic monitoring. Concordant events (n=94), in which events were recorded with both the smart button and electronic monitoring, occurred 47% of the time and 58% of these events occurred within ±5 min of one another. Participant comments suggested SMS text messages were encouraging. CONCLUSIONS: It was feasible to recruit participants in the clinic setting for an mHealth study, and our system was successfully initiated for all enrolled participants. The smart button is an innovative way to self-report adherence data, including date and timing of medication taking, which were not previously available from measures that rely on recall of adherence. Although the selected smart button had poor concordance with electronic monitoring caps, participants were willing to use it to self-track medication adherence, and they found the mHealth system acceptable to use in most cases

Repetitive Segmental Structure of the Transducin β Subunit: Homology with the CDC4 Gene and Identification of Related mRNAs

Retinal transducin, a guanine nucleotide regulatory protein (referred to as a G protein) that activates a cGMP phosphodiesterase in photoreceptor cells, is comprised of three subunits. We have identified and analyzed cDNA clones of the bovine transducin β subunit that may be highly conserved or identical to that in other G proteins. From the cDNA nucleotide sequence of the entire coding region, the primary structure of a 340-amino acid protein was deduced. The encoded β subunit has a Mr of 37,375 and is comprised of repetitive homologous segments arranged in tandem. Furthermore, significant homology in primary structure and segmental sequence exists between the β subunit and the yeast CDC4 gene product. The Mr 37,375 β subunit polypeptide is encoded by a 2.9-kilobase (kb) mRNA. However, there exists in retina other β-related mRNAs that are divergent from the 2.9-kb mRNA on the basis of oligonucleotide and primer-extended probe hybridizations. All mammalian tissues and clonal cell lines that have been examined contain at least two β-related mRNAs, usually 1.8 and 2.9 kb in length. These results suggest that the mRNAs are the processed products of a small number of closely related genes or of a single highly complex β gene

HabEx polarization ray trace and aberration analysis

The flux difference between a terrestrial exoplanet and a much brighter nearby star creates an enormous optical design challenge for space-based imaging systems. Coronagraphs are designed to block the star’s flux and obtain a high-dynamic-range image of the exoplanet. The contrast of an optical system is calculated using the point spread function (PSF). Contrast quantifies starlight suppression of an imaging system at a given separation of the two objects. Contrast requirements can be as small as 10^(−10) for earth-like planets. This work reports an analysis of the September 2017 Habitable Exoplanet Imaging Mission (HabEx) end-to-end optical system prescription for geometric and polarization aberrations across the 450 to 550 nm channel. The Lyot coronagraph was modeled with a vector vortex charge 6 mask but without adaptive optics (AO) to correct the phase of the Jones pupil. The detector plane irradiance was calculated for three states of the telescope/coronagraph system: (1) free of geometric and polarization aberrations; (2) isotropic mirror coatings throughout the end-toend system; and (3) isotropic mirrors with form birefringence on the primary mirror. For each of these three states the system response both with and without a coronagraph mask was calculated. Two merit functions were defined to quantify the system’s ability to attenuate starlight: (1) normalized polychromatic irradiance (NPI), and (2) starlight suppression factor (SSF). Both of these are dimensionless and their values are functions of position across the focal plane. The NPI is defined as the irradiance point-by-point across the detector plane with a coronagraph mask divided by the value of the on-axis irradiance without a coronagraph mask. The SSF is the irradiance point-by-point across the detector plane with a coronagraph mask divided by the pointby-point value of the irradiance across the detector plane without a coronagraph mask. Both the NPI and the SSF provide insights into coronagraph performance. Deviations from the aberration-free case are calculated and summarized in table 2. The conclusions are: (1) the HabEx optical system is well-balanced for both geometric and polarization aberrations; (2) the spatially dependent polarization reflectivity for the HabEx primary mirror should be specified to ensure the coating is isotropic; (3) AO to correct the two orthogonal polarization-dependent wavefront errors is essential

Evaluation of Hay-Type and Grazing Tolerant Alfalfa Hybrids in Season-Long or Complementary Rotational Stocking Systems for Beef Cows

Pastures containing hay-type and grazing tolerant alfalfa hybrids were grazed in a season-long or complementary rotational stocking system with Nfertilized smooth bromegrass. The pastures were stocked at a seasonal density of .8 cow-calf pairs per acre for 120 days in 1998 and 141 days in 1999. Pastures were intensively managed by daily stripstocking with the assumptions that 50% of live forage was available and daily live dry matter consumption of each cow-calf pair was 3.5% of the cow’s body weight. First-cutting forage was harvested as hay from 40% of the pasture acres to remove excess forage growth early in the grazing season. Grazing occurred on the remaining 60% of each pasture for the first 44 and 54 days and 100% of each pasture after days 45 and 55 in 1998 and 1999, respectively. Proportions of ‘Amerigraze’ and ‘Affinity’ alfalfa in the live forage dry matter decreased by 70% and 55% in pastures stocked season-long and by 60% and 42% in pastures used for complementary stocking (alfalfa type, p\u3c.05; grazing management, p\u3c.05) in 1998, but decreased by a mean of 72% and was unaffected by hybrid or stocking system in 1999. Cows grazing either alfalfa hybrid by either grazing system had greater weight gains during the breeding and overall grazing seasons and greater increases in body condition score pre-breeding and during the breeding season than the cows that grazed smooth bromegrass for the entire season in 1998. Also, cows grazing either alfalfa hybrid in the season-long system had greater breeding season increases in body condition score than cows grazing alfalfa in the complementary system with smooth bromegrass in 1998. Cows grazing in the season-long alfalfa system had greater prebreeding season weight (p\u3c.10) increases and condition score (p\u3c.05) increases than cows grazing alfalfa in the complementary system in 1999. Daily and seasonal body weight gains of calves were not affected (p\u3e.10) by the presence of alfalfa in 1998 or by alfalfa type and grazing management in 1998 and 1999. Total animal production (cow and calf) in 1998 was greater (p\u3c.10) from the season-long alfalfa pastures compared with the complementary stocked pastures. Total (p\u3c.10) and live (p\u3c.05) forage masses, estimated by monthly clippings, were greater in September of 1998 from the season-long alfalfa pastures than pastures using alfalfa for complementary stocking. Total (p\u3c.10) and live (p\u3c.05) forage masses were greater in August of 1999 from season-long alfalfa pastures than pastures using alfalfa for complementary stocking