INFLAMMATORY DISEASES OF THE BILIARY TRACT IN CHILDREN UP TO 3 YEARS OLD

No abstrac

ROTAVIRUS GASTROENTERITIS IN SUCKLINGS

No abstrac

PROSTAGLANDINS AS AN INFORMATION MEANS CONCERNING THE VITAL CHARACTER AND DURATION OF SKIN INJURIES

No abstrac

ON THE ETIOLOGICAL ROLE OF ROTAVIRUSES AND SOME REPRESENTATIVES OF AEROBIC INTESTINAL MICROFLORA OF CHILDREN'S GASTROENTERITIS

No abstrac

Bottom-Up Synthesis of Polymeric Micro- and Nanoparticles with Regular Anisotropic Shapes

Shape-anisotropic polymeric micro- and nanoparticles are of significant interest for the development of novel composite materials, lock-and-key assemblies, and drug carriers. Currently, syntheses require external confinement in microfluidic devices or lithographic techniques associated with significant infrastructure and low productivity, so new methods are necessary to scale-up such production efficiently. Here we report bottom-up polymerization of regular shape-anisotropic particles (polygonal platelets with different numbers of edges, with and without protruding asperities, and fibrilar particles with controllable aspect ratios), with size control over 4 orders of magnitude (∼50 nm-1 mm). Polymerization also enables the study of much smaller shapes than could previously be studied in water suspensions, and we study the fundamental limits of the self-shaping transition process driving these transformations for monomer oil droplets of stearyl methacrylate (SMA) monomer oil. We show the method is compatible with a variety of polymerizing monomers and functional modifications of the particles (e.g., composites with magnetic nanoparticles, oil-soluble additives, etc.). We also describe postsynthetic surface modifications that lead to hierarchical superstructures. The synthesis procedure has great potential in efficient nanomanufacturing as it can achieve scalable production of the above shapes in a wide range of sizes, with minimum infrastructure and process requirements and little maintenance of the equipment

Хроническая мигрень, ассоциированная с сахарным диабетом I типа

Catedra Neurologie, USMF „Nicolae Testemiţanu”, Institutul de Neurologie şi NeurochirurgieMigraine is estimated to be found in about 30% of patients with diabetes mellitus (DM) type I. The migraine associated with DM is a complex scientific and clinical problem. The article is a case presentation of a patient with chronic migraine (ChM) associated with DM type I having clinical manifestations which included daily medium to strong headaches located unilaterally or bilaterally with a compressive or pulsating pattern lasting more than 4 hours, sometimes associated with nausea, vomiting, photophobia, phonophobia or osmophobia. Headache attacks were aggravated by physical effort or stress. The patient has a genetic predisposition to migraine (her mother and brother suffered from ChM for many years). The patient underwent a complex examination: EEG, fundoscopy, angio-CT and MRI of the brain, ECG, ultrasound of the abdominal organs, and a radioscopy of the stomach. The psychometric evaluation utilized the Spielberger and Beck questionnaire. The test revealed a moderate level of anxiety and depression, as well as the patient’s histrionic personality. Effective treatment of metabolical changes in DM contributed to the reduction of the intensity and frequency of migraine attacks.Частота распространенности мигрени высока среди пациентов, которые давно страдают сахарным диабетом (СД) I типа, в среднем около 30%. Сопутствующая сахарному диабету мигрень представляет собой сложную и интересную в научном плане задачу. Представлен клинический случай пациентки с хронической мигренью (ХМ) в сочетании с СД I типа. В клинической картине были ежедневные приступы головной боли, средней и сильной интенсивности, одно- или двухсторонние, сжимающего или пульсирующего характера, длительностью более 4-х часов, сочетающиеся с тошнотой, иногда рвотой, фото-, фоно- и осмофобией. Приступы усиливались при физической нагрузке или при психоэмоциональных стрессах. У пациентки присутствовала генетическая предрасположенность к мигрени (мать и брат страдают хронической мигренью в течение многих лет). Больная была многосторонне обследована: ЭЭГ, офтальмоскопия, ангио-КТ, МРТ головного мозга, ЭКГ, УЗИ органов брюшной полости, Rg-скопия желудка и т.д. Психометрические тесты (Спилберг, Бек, DSM-IV опросник), выявили высокий уровень реактивной и личностной тревоги, депрессию средней степени выраженности, а также черты хистрионической личности. Эффективное лечение расстройств способствовало уменьшению интенсивности и частоты сопутствующих мигренозных атак

The role of the complement system in traumatic brain injury: a review

Traumatic brain injury (TBI) is an important cause of disability and mortality in the western world. While the initial injury sustained results in damage, it is the subsequent secondary cascade that is thought to be the significant determinant of subsequent outcomes. The changes associated with the secondary injury do not become irreversible until some time after the start of the cascade. This may present a window of opportunity for therapeutic interventions aiming to improve outcomes subsequent to TBI. A prominent contributor to the secondary injury is a multifaceted inflammatory reaction. The complement system plays a notable role in this inflammatory reaction; however, it has often been overlooked in the context of TBI secondary injury. The complement system has homeostatic functions in the uninjured central nervous system (CNS), playing a part in neurodevelopment as well as having protective functions in the fully developed CNS, including protection from infection and inflammation. In the context of CNS injury, it can have a number of deleterious effects, evidence for which primarily comes not only from animal models but also, to a lesser extent, from human post-mortem studies. In stark contrast to this, complement may also promote neurogenesis and plasticity subsequent to CNS injury. This review aims to explore the role of the complement system in TBI secondary injury, by examining evidence from both clinical and animal studies. We examine whether specific complement activation pathways play more prominent roles in TBI than others. We also explore the potential role of complement in post-TBI neuroprotection and CNS repair/regeneration. Finally, we highlight the therapeutic potential of targeting the complement system in the context of TBI and point out certain areas on which future research is needed

International Conference on Computer Systems and Technologies- CompSysTech’2003 Using the MSSP Module of PIC16F87X Microcontroller in Master Mode

Abstract: The paper considers the utilizing of the master synchronous serial port (MSSP) module of the microcontrollers of the PIC16F87X Microchip family in master mode for I 2 C communications. An algorithm for processing the status of the transfer is presented. Key words: microcontroller PIC16F87X, master synchronous serial port MSSP, I 2 C communications, special function registers