Preprint arXiv: 2106.14858 Submitted on 28 Jun 2021

In the absence of dissipation a non-rotating magnetic nanoparticle can be stably levitated in a static magnetic field as a consequence of the spin origin of its magnetization. Here, we study the effects of dissipation on the stability of the system, considering the interaction with the background gas and the intrinsic Gilbert damping of magnetization dynamics. We find that dissipation limits the time over which a particle can be stably levitated. At large applied magnetic fields we identify magnetization switching induced by Gilbert damping as the key limiting factor for stable levitation. At low applied magnetic fields and for small particle dimensions magnetization switching is prevented due to the strong coupling of rotation and magnetization dynamics, and the stability is mainly limited by the gas-induced dissipation. In this latter case, high vacuum should be sufficient to extend stable levitation over experimentally relevant timescales. Our results demonstrate the possibility to experimentally observe the phenomenon of quantum spin stabilized magnetic levitation

Stability of a magnetically levitated nanomagnet in vacuum: Effects of gas and magnetization damping

In the absence of dissipation a non-rotating magnetic nanoparticle can be stably levitated in a static magnetic field as a consequence of the spin origin of its magnetization. Here we study the effects of dissipation on the stability of the system, considering the interaction with the background gas and the intrinsic Gilbert damping of magnetization dynamics. At large applied magnetic fields we identify magnetization switching induced by Gilbert damping as the key limiting factor for stable levitation. At low applied magnetic fields and for small particle dimensions magnetization switching is prevented due to the strong coupling of rotation and magnetization dynamics, and the stability is mainly limited by the gas-induced dissipation. In the latter case, high vacuum should be sufficient to extend stable levitation over experimentally relevant timescales. Our results demonstrate the possibility to experimentally observe the phenomenon of quantum spin stabilized magnetic levitation.Comment: 13 pages, 6 figures, revised versio

Cryogenic light detectors with enhanced performance for rare events physics

We have developed and tested a new way of coupling bolometric light detectors to scintillating crystal bolometers based upon simply resting the light detector on the crystal surface, held in position only by gravity. This straightforward mounting results in three important improvements: (1) it decreases the amount of non-active materials needed to assemble the detector, (2) it substantially increases the light collection efficiency by minimizing the light losses induced by the mounting structure, and (3) it enhances the thermal signal induced in the light detector thanks to the extremely weak thermal link to the thermal bath. We tested this new technique with a 16 cm$^2$ Ge light detector with thermistor readout sitting on the surface of a large TeO$_2$ bolometer. The light collection efficiency was increased by greater than 50\% compared to previously tested alternative mountings. We obtained a baseline energy resolution on the light detector of 20~eV RMS that, together with increased light collection, enabled us to obtain the best $\alpha$ vs $\beta/\gamma$ discrimination ever obtained with massive TeO$_2$ crystals. At the same time we achieved rise and decay times of 0.8 and 1.6 ms, respectively. This superb performance meets all of the requirements for the CUPID (CUORE Upgrade with Particle IDentification) experiment, which is a 1-ton scintillating bolometer follow up to CUORE.Comment: 6 pages, 4 figure

Capillary electrophoretic and extraction conditions for the analysis of Catha edulis FORKS active principles

A capillary electrophoretic method, which allowed the detection and separation of the active principles of Catha edulis, i.e. cathinone, cathine and phenylpropanolamine, was developed. A suitable internal standard (nicotinamide), which permitted the quantification of the analytes reducing the variability of the migration times due to EOF changes, was identified. The analytical method was validated, assessing linearity, sensitivity and repeatability, showing optimal features for the analysis of the vegetable material. Moreover extraction conditions were investigated to achieve the exhaustion of the plant material in the fastest and most efficient way to meet the requirements of the Court

Preclinical and clinical evidence on the approach-avoidance conflict evaluation as an integrative tool for psychopathology

The approach-avoidance conflict (AAC), i.e. the competing tendencies to undertake goal-directed actions or to withdraw from everyday life challenges, stands at the basis of humans' existence defining behavioural and personality domains. Gray's Reinforcement Sensitivity Theory posits that a stable bias toward approach or avoidance represents a psychopathological trait associated with excessive sensitivity to reward or punishment. Optogenetic studies in rodents and imaging studies in humans associated with cross-species AAC paradigms granted new emphasis to the hippocampus as a hub of behavioural inhibition. For instance, recent functional neuroimaging studies show that functional brain activity in the human hippocampus correlates with threat perception and seems to underlie passive avoidance. Therefore, our commentary aims to (i) discuss the inhibitory role of the hippocampus in approach-related behaviours and (ii) promote the integration of functional neuroimaging with cross-species AAC paradigms as a means of diagnostic, therapeutic, follow up and prognosis refinement in psychiatric populations

CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail

Mutations in the human X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in patients with Rett syndrome (RTT), West syndrome, and X-linked infantile spasms, sharing the common feature of mental retardation and early seizures. CDKL5 is a rather uncharacterized kinase, but its involvement in RTT seems to be explained by the fact that it works upstream of MeCP2, the main cause of Rett syndrome. To understand the role of this kinase for nervous system functions and to address if molecular mechanisms are involved in regulating its distribution and activity, we studied the ontogeny of CDKL5 expression in developing mouse brains by immunostaining and Western blotting. The expression profile of CDKL5 was compared with that of MeCP2. The two proteins share a general expression profile in the adult mouse brain, but CDKL5 levels appear to be highly modulated at the regional level. Its expression is strongly induced in early postnatal stages, and in the adult brain CDKL5 is present in mature neurons, but not in astroglia. Interestingly, the presence of CDKL5 in the cell nucleus varies at the regional level of the adult brain and is developmentally regulated. CDKL5 shuttles between the cytoplasm and the nucleus and the C-terminal tail is involved in localizing the protein to the cytoplasm in a mechanism depending on active nuclear export. Accordingly, Rett derivatives containing disease-causing truncations of the C terminus are constitutively nuclear, suggesting that they might act as gain of function mutations in this cellular compartment

Development of a Li2MoO4 scintillating bolometer for low background physics

We present the performance of a 33 g Li2MoO4 crystal working as a scintillating bolometer. The crystal was tested for more than 400 h in a dilution refrigerator installed in the underground laboratory of Laboratori Nazionali del Gran Sasso (Italy). This compound shows promising features in the frame of neutron detection, dark matter search (solar axions) and neutrinoless double-beta decay physics. Low temperature scintillating properties were investigated by means of different alpha, beta/gamma and neutron sources, and for the first time the Light Yield for different types of interacting particle is estimated. The detector shows great ability of tagging fast neutron interactions and high intrinsic radiopurity levels (< 90 \muBq/kg for 238-U and < 110 \muBq/kg for 232-Th).Comment: revised versio