Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity.

GABA transporters control extracellular GABA, which regulates the key aspects of neuronal and network behaviour. A prevailing view is that modest neuronal depolarization results in GABA transporter type-1 (GAT-1) reversal causing non-vesicular GABA release into the extracellular space during intense network activity. This has important implications for GABA uptake-targeting therapies. Here we combined a realistic kinetic model of GAT-1 with experimental measurements of tonic GABAA receptor currents in ex vivo hippocampal slices to examine GAT-1 operation under varying network conditions. Our simulations predict that synaptic GABA release during network activity robustly prevents GAT-1 reversal. We test this in the 0 Mg(2+) model of epileptiform discharges using slices from healthy and chronically epileptic rats and find that epileptiform activity is associated with increased synaptic GABA release and is not accompanied by GAT-1 reversal. We conclude that sustained efflux of GABA through GAT-1 is unlikely to occur during physiological or pathological network activity

Asymptotic Learning Curve and Renormalizable Condition in Statistical Learning Theory

Bayes statistics and statistical physics have the common mathematical structure, where the log likelihood function corresponds to the random Hamiltonian. Recently, it was discovered that the asymptotic learning curves in Bayes estimation are subject to a universal law, even if the log likelihood function can not be approximated by any quadratic form. However, it is left unknown what mathematical property ensures such a universal law. In this paper, we define a renormalizable condition of the statistical estimation problem, and show that, under such a condition, the asymptotic learning curves are ensured to be subject to the universal law, even if the true distribution is unrealizable and singular for a statistical model. Also we study a nonrenormalizable case, in which the learning curves have the different asymptotic behaviors from the universal law

Summing Over Inequivalent Maps in the String Theory Interpretation of Two Dimensional QCD

Following some recent work by Gross, we consider the partition function for QCD on a two dimensional torus and study its stringiness. We present strong evidence that the free energy corresponds to a sum over branched surfaces with small handles mapped into the target space. The sum is modded out by all diffeomorphisms on the world-sheet. This leaves a sum over disconnected classes of maps. We prove that the free energy gives a consistent result for all smooth maps of the torus into the torus which cover the target space $p$ times, where $p$ is prime, and conjecture that this is true for all coverings. Each class can also contain integrations over the positions of branch points and small handles which act as ``moduli'' on the surface. We show that the free energy is consistent for any number of handles and that the first few leading terms are consistent with contributions from maps with branch points.Comment: 17 pages, 5 eps figures contained in a uuencoded file, UVA-HET-92-1

The Color--Flavor Transformation of induced QCD

The Zirnbauer's color-flavor transformation is applied to the $U(N_c)$ lattice gauge model, in which the gauge theory is induced by a heavy chiral scalar field sitting on lattice sites. The flavor degrees of freedom can encompass several `generations' of the auxiliary field, and for each generation, remaining indices are associated with the elementary plaquettes touching the lattice site. The effective, color-flavor transformed theory is expressed in terms of gauge singlet matrix fields carried by lattice links. The effective action is analyzed for a hypercubic lattice in arbitrary dimension. We investigate the corresponding d=2 and d=3 dual lattices. The saddle points equations of the model in the large-$N_c$ limit are discussed.Comment: 24 pages, 6 figures, to appear in Int. J. Mod. Phys.

Some New/Old Approaches to QCD

This is a talk delivered at the Meeting on Integrable Quantum Field Theories, Villa Olmo and at STRINGS 1992, Rome, September 1992. I discuss some recent attempts to revive two old ideas regarding an analytic approach to QCD-the development of a string representation of the theory and the large N limit of QCD.Comment: 20 page

Density Correlation Functions in Calogero Sutherland Models

Using arguments from two dimensional Yang-Mills theory and the collective coordinate formulation of the Calogero-Sutherland model, we conjecture the dynamical density correlation function for coupling $l$ and $1/l$, where $l$ is an integer. We present overwhelming evidence that the conjecture is indeed correct.Comment: 12 pages phyzzx, CERN-TH/94.7243 One reference change

Structural and magnetic studies of FE100–xCox nanotubes obtaine by template method

Hollow nanostructures based on the Fe100–xCox alloy were synthesized in the pores of polymer template matrices based on PET using the electrochemical deposition method. Morphology, elemental composition, and structural features were characterized by scanning electron microscopy, energy dispersive analysis, and X-ray diffractometry. The study of the internal magnetic texture was carried out using Mossbauer spectroscopy. The dependence of the change in structural and magnetic properties from the atomic content of components in nanotube structure is revealed. It is established that the synthesized nanostructures are hollow Fe100–xCox nanotubes with a body-centered cubic crystal structure. The decrease in the unit cell parameter with increasing cobalt concentration is due to the difference in the radii of Fe (1.227 Å) and Co (1.191 Å) atoms. It is established that a random distribution of magnetic moments directions of Fe atoms is observed for Fe100Co0 nanotubes. And magnetic texture along the nanotube axis is observed for Fe100–xCox nanotubes, with an increase in Co atoms concentration. The average angle between the direction of the magnetic moment of iron atoms and the nanotube axis decreases from v = 54:6° to v = 24:5°. © 2018, Electromagnetics Academy. All rights reserved

Template synthesis and magnetic characterization of FeNi nanotubes

Iron-nickel nanotubes consisting of 20% Ni and 80% Fe with an aspect ratio of about 100 were synthesized by electrochemical deposition in the pores of polyethylene terephthalate ion-track membranes. The main morphological parameters such as composition, wall thickness and structural characteristics were defined. Macro- and micromagnetic parameters of FeNi nanotubes were determined. © 2017, Electromagnetics Academy. All rights reserved

ХИМИОТЕРАПИЯ МЫШЕЧНО-ИНВАЗИВНОГО РАКА МОЧЕВОГО ПУЗЫРЯ

The paper considers treatment regimens for metastatic bladder cancer (MBC) and gives the data of trials of the efficiency of using different chemotherapy schemes and regimens in patients with MBC.Рассматриваются схемы лечения метастатического рака мочевого пузыря (РМП), приводятся данные исследований эффективности применения различных схем и режимов химиотерапии пациентов с РМП