Investment funds as financing alternative to revive local industry

The paper is oriented toward identifying the benefits offered by investment funds as financing alternatives to those entities in need for funding, thus in financing their growth. The research is developed as a case study being carried out for private equity investments example within the Romanian market. This alternative investment vehicle present the most comprehensive range of operations carried out by investment funds and their example can expose both the benefits and tradeoffs attached to this financing alternative financing. Methodologically, the analysis covers all stages of investment funds related to demarcation of the target entity, from the selection, evaluation, implementation, monitoring until the multiplication of investment while liquidation is in place

Análisis económico-financiero de las entidades locales e influencia del nivel de transparencia

El propósito de este trabajo es analizar la situación económico-financiera de los ayuntamientos, e identificar si existe alguna relación entre el nivel de transparencia que muestran según el Índice de Transparencia de los Ayuntamientos y su situación financiera. Para ello se toma una muestra de 50 ayuntamientos españoles en base a la puntuación global obtenida en el año 2017 en el índice, clasificándolos entre los 25 ayuntamientos más transparentes y los 25 menos transparentes. Se observa que en los últimos años los ayuntamientos muestran una evolución favorable en cuanto a nivel de transparencia, debido tanto a la evaluación realizada por Transparencia Internacional como a la ley de transparencia. El análisis de los resultados obtenidos a través de la comparación de los ratios, muestra que los ayuntamientos más transparentes tienen una mejor posición de liquidez, solvencia, periodos de cobro y pago, así como en algunos indicadores presupuestarios, aunque en el análisis estadístico no todas estas diferencias se muestran estadísticamente significativas.<br /

Structural Features of the Cardia Gastric Region in Domestic Rabbits

The knowledge of normal microscopical peculiarities of the digestive system in mammals is essential, but information regarding certain structures is still scarce in numerous species. Our study aims to highlight the normal morphological features of the cardia region in domestic rabbits, as regards the overall appearance, structure, and dimensions of the gastric pits, including a description of the cells located in gastric glands. The cardia region of five domestic rabbits underwent tissue sampling, followed by fixation in 10% buffered formalin, paraffin embedding, and later sectioned at 5 µm in thickness. Eventually, the samples were stained by Goldner’s trichrome method. The microscopical examination has revealed the presence of gastric pits and glands in the entire cardia region of the rabbit, with a different morphological appearance from one zone to another. Gastric pits have the smallest depth immediately after the oesophagogastric junction, which gradually increases and decreases afterwards as it approaches the fundic zone. The gastric glands contain basically four cell types in various proportions, including serous cells, mucous cells, parietal cells, and chief cells. Other peculiarities of the gastric mucosa in the cardia region in rabbits include a thick mucosa with a loose and prominent lamina propria, and an ill-defined muscularis mucosae that is not organized in distinct layers as in other species. The detailed microanatomical structure of the cardia region of the stomach is necessary for understanding the digestion processes in rabbits, species used as a model in diverse fields of research including the pathology of the digestive system

Histochemical Evaluation of Mucin-Secreting Cell Activity in the Stomach of the Wistar Rat

Mucin plays a very important role in the physiological function of the stomach in all species, but the representation of mucin-secreting cells differs from species to species. The aim of this study was to highlight these cells in the stomach of the Wistar rat. For histological investigations, fragments of the stomach from the three main regions (cardiac, fundic and pyloric) were harvested from four Wistar rats and further stained with PAS and Alcian blue methods. The histochemical results showed the presence of mucin-secreting cells in the examined tissues. An intense PAS positive reaction was found in the surface epithelium cells of the gastric mucosa and in the cells lining the gastric crypts in all the three segments. In the deep glandular structures, the cells of the cardiac and fundic glands are PAS negative, while those of the pyloric glands are all PAS positive. For Alcian blue reaction, the cells lining the gastric mucosa and the crypts in the three regions of the stomach were negative. In the glands, the cells of the cardiac and fundic glands were Alcian negative while in the pyloric glands, a limited number of cells arranged in the deep third of the glands showed a weak positive Alcian reaction. In conclusion, the vast majority of glandular cells in the rat's stomach do not synthesize acidic mucins, except for cells in the deep part of the pyloric glands, which synthesize small amounts of such mucins

Overview of the Side-Effects of FDA- and/or EMA-Approved Targeted Therapies for the Treatment of Hematological Malignancies.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadIn the last decade there has been tremendous effort in offering better therapeutic management strategies to patients with hematologic malignancies. These efforts have ranged from biological to clinical approaches and resulted in the rapid development of new approaches. The main "problem" that comes with the high influx of newly approved drugs, which not only influences hematologists that frequently work with these drugs but also affects other healthcare professionals that work with hematologists in patient management, including intensive care unit (ICU) physicians, is they have to keep up within their specialty and, in addition, with the side-effects that can occur when encountering hematology-specific therapies. Nonetheless, there are few people that have an in-depth understanding of a specialty outside theirs. Thus, this manuscript offers an overview of the most common side-effects caused by therapies used in hematology nowadays, or that are currently being investigated in clinical trials, with the purpose to serve as an aid to other specialties. Nevertheless, because of the high amount of information on this subject, each chapter will offer an overview of the side-effects of a drug class with each reference of the section being intended as further reading. Keywords: hematological malignancies; life-threatening side-effects; novel therapies.MDPI A

Assessing the Benefits of Lifestyle Influences on Cardiovascu-lar Health After Acute Coronary Syndrome

The objective of our study was to explore the potential benefits of combining moderate alcohol consumption with regular vigorous physical activity on HDL-cholesterol levels and its poten-tial positive impact on cardiovascular health. Materials and methods: The study comprised two groups: group A (102 patients) that consumed 10 grams of alcohol per day, specifically red wine, and increased their exercise levels in addition to their standard medical treatment, and group B (108 patients) which adhered only to their standard medical treatment. The patients were monitored for a year, during which various clinical parameters were observed. Results: Our study showed that moderate alcohol consumption, particularly red wine, along with in-creased physical activity levels, were associated with enhancements in exercise tolerance and elevated levels of HDL-cholesterol. Our findings suggest the efficacy of the intervention in im-proving lipid profiles, with the group that consumed alcohol as part of their treatment scheme, generally experiencing more pronounced positive effects. Statistically significant differences between groups in terms of angina evolution, acute myocardial infarction (AMI) recurrence, or arrhythmias evolution were not found. However, there were important differences in terms of ejection fraction (EF) improvement and quality of life, with the alcohol consuming group dis-playing greater improvements in both aspects. Conclusions: In conclusion, our study empha-sizes the potential benefits of combining moderate alcohol consumption, specifically red wine, with increased physical activity levels for improving exercise tolerance and enhancing HDL-cholesterol levels. However, further research and clinical trials are essential to fully un-derstand the mechanisms and optimize the integration of these lifestyle elements for improved cardiovascular health outcomes