EWE: Toward electro-mechanical cardiac simulations with MOOSE

We present the software framework EWE, which is designed for coupled electromechanical simulations in computational cardiology. EWE is build on the multi-physics framework MOOSE. Numerical simulations of coupled problems on an idealized geometry for a left ventricle are shown

Does Boris-SDC conserve phase space volume?

In this paper we investigate the conservation of phase space volume of the Boris-SDC algorithm. This method provides a generic way to extend the standard, second-order accurate Lorentz force integrator commonly used for charged particles in an electric and magnetic field to a high-order method using spectral deferred corrections. For a single particle in a Penning trap and different frequencies of the electric and magnetic fields, we assess the conservation properties of the method by computing the update matrix of one step of Boris-SDC as well as its determinant. We compare the results to the convergence regions and relate them to energy conservation properties of the method

Dynamic Aperture Studies for the Transfer Line From FLUTE to cSTART

The compact STorage ring for Accelerator Research and Technology cSTART project will deliver a new KIT accelerator test facility for the application of novel acceleration techniques and diagnostics. The goal is to demonstrate storing an electron beam of a Laser Plasma Accelerator (LPA) in a compact circular accelerator for the first time. Before installing an LPA, the Far-Infrared Linac and Test Experiment (FLUTE) will serve as a full energy injector for the compact storage ring, providing stable bunches with a length down to a few femtoseconds. The transport of the bunches from FLUTE to the cSTART storage ring requires a transfer line which includes horizontal, vertical and coupled deflections which leads to coupling of the dynamics in the two transverse planes. In order to realize ultra-short bunch lengths at the end of the transport line, it relies on special optics which invokes high and negative dispersion. This contribution presents dynamic aperture studies based on six-dimensional tracking through the lattice of the transfer line

Status of the FLUTE RF System Upgrade

FLUTE (Ferninfrarot Linac- Und Test-Experiment) is a compact versatile linac-based accelerator test facility at KIT. Its main goal is to serve as a platform for a variety of accelerator studies and to generate strong ultra-short THz pulses for photon science. It will also serve as an injector for a Very Large Acceptance compact Storage Ring (VLA-cSR), which will be realized at KIT in the framework of the compact STorage Ring for Accelerator Research and Technology (cSTART) project. To achieve acceleration of electrons in the RF photoinjector and LINAC (from FLUTE) with high stability, it is necessary to provide stable RF power. For this goal, an upgrade of the existing RF system design has been proposed and is currently being implemented. This contribution will report on the updated RF system design and the commissioning status of the new RF system components

Alpha-buckets in High Energy Electron Storage Rings (Review of Existing Experiments and Feasibility Studies for Future Developments) Review

Electron storage rings operating at high energies have proven to be invaluable source of synchrotron radiation. Two and even three simultaneous beams of particles have been observed at different light source facilities worldwide. So called alpha-buckets were studied at Metrological Light Source (MLS) in Berlin (Germany), SOLEIL facility in France, DIAMOND light source in UK, NSLS ring in Brookhaven (USA). It is widely recognized that alpha buckets are general phenomena which is not restricted to a certain storage ring. However, earlier measurements showed essential limitations on parameters of alpha-buckets, strong dependence on high order (sextupole and octupoles) magnetic field imperfections and associated fast decay of electron current as well as reduced life time. Also a rising relevance of high order non-linear longitudinal beam dynamics is associated with new generation of diffraction limited light sources (DLSR) approaches, which all suffer nonlinear momentum compaction factor. A large variety of future generation electron synchrotrons require a comprehensive investigation of the physical processes involved into the operation of such rings. In this paper, we present review of high order non-linear longitudinal beam dynamics based on the longitudinal equations of motion and Hamiltonian expanded to a high order of the momentum compaction factor. Roots of the third order equation with a free term are derived in a form suitable for analytical estimations. The momentum independent term of orbit lengthening due to particle transverse excursions is estimated and taken into account. The results from simulations were benchmarked against existing experiments at the Karlsruhe Research Accelerator (KARA), SOLEIL and MLS rings. Parameters of three simultaneous beams and alpha buckets at MLS and SOLEIL have been reproduced with high accuracy. General conditions for stable operation of alpha buckets are presented. Based on analytical formulas and computer simulations, studies of longitudinal motion at KARA have been performed with an objective to estimate feasibility of filling and storing of beam in α-buckets. A Computer model was used to describe the behavior and dynamics of simultaneous beams in the KARA storage ring

Bosons in anisotropic traps: ground state and vortices

We solve the Gross-Pitaevskii equations for a dilute atomic gas in a magnetic trap, modeled by an anisotropic harmonic potential. We evaluate the wave function and the energy of the Bose Einstein condensate as a function of the particle number, both for positive and negative scattering length. The results for the transverse and vertical size of the cloud of atoms, as well as for the kinetic and potential energy per particle, are compared with the predictions of approximated models. We also compare the aspect ratio of the velocity distribution with first experimental estimates available for $^{87}$Rb. Vortex states are considered and the critical angular velocity for production of vortices is calculated. We show that the presence of vortices significantly increases the stability of the condensate in the case of attractive interactions.Comment: 22 pages, REVTEX, 8 figures available upon request or at http://anubis.science.unitn.it/~dalfovo/papers/papers.htm

Beyond the Thomas-Fermi approximation for a trapped condensed Bose-Einstein gas

Corrections to the zero-temperature Thomas-Fermi description of a dilute interacting condensed Bose-Einstein gas confined in an isotropic harmonic trap arise due to the presence of a boundary layer near the condensate surface. Within the Bogoliubov approximation, the various contributions to the ground-state condensate energy all have terms of order R^{-4}ln R and R^{-4}, where R is the number-dependent dimensionless condensate radius in units of the oscillator length. The zero-order hydrodynamic density-fluctuation amplitudes are extended beyond the Thomas-Fermi radius through the boundary layer to provide a uniform description throughout all space. The first-order correction to the excitation frequencies is shown to be of order R^{-4}.Comment: 12 pages, 2 figures, revtex. Completely revised discussion of the boundary-layer corrections to collective excitations, and two new figures added. To appear in Phys. Rev. A (October, 1998

Beam Dynamics Observations at Negative Momentum Compaction Factors at KARA

For the development of future synchrotron light sources new operation modes often have to be considered. One such mode is the operation with a negative momentum compaction factor to provide the possibility of increased dynamic aperture. For successful application in future light sources, the influence of this mode has to be investigated. At the KIT storage ring KARA (Karlsruhe Research Accelerator), operation with negative momentum compaction has been implemented and the dynamics can now be investigated. Using a variety of high-performance beam diagnostics devices it is possible to observe the beam dynamics under negative momentum compaction conditions. This contribution presents different aspects of the results of these investigations in the longitudinal and transversal plane

Coherent Dynamics of Vortex Formation in Trapped Bose-Einstein Condensates

Simulations of a rotationally stirred condensate show that a regime of simple behaviour occurs in which a single vortex cycles in and out of the condensate. We present a simple quantitative model of this behaviour, which accurately describes the full vortex dynamics, including a critical angular speed of stirring for vortex formation. A method for experimentally preparing a condensate in a central vortex state is suggested.Comment: 4 pages, 4 figures, REVTeX 3.1; Submitted to Physical Review Letters (5 February 1999); See http://www.physics.otago.ac.nz/research/bec/vortex for MPEG movies and further information; Accepted for Physical Review Letters (24 June 1999); Changes: updated Figs 1 and 2 (new style), minor typos fixed, more discussion at en

Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis

Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS). Studies in rodent models demonstrated an association of CNS-infiltrating monocyte-derived macrophages with disease severity. However, little is known about humans. Here, we performed an exploratory analysis of peripheral blood mononuclear cells (PBMCs) isolated from healthy controls and drug-naïve patients with early MS using multiplexed single-cell mass cytometry and algorithm-based data analysis. Two antibody panels comprising a total of 64 antibodies were designed to comprehensively analyse diverse immune cell populations, with particular emphasis on monocytes. PBMC composition and marker expression were overall similar between the groups. However, an increased abundance of CCR7+ and IL-6+ T cells was detected in early MS-PBMCs, whereas NFAT1hiT-bethiCD4+ T cells were decreased. Similarly, we detected changes in the subset composition of the CCR7+ and MIPβhi HLA-DR+ lymphocyte compartment. Only mild alterations were detected in monocytes/myeloid cells of patients with early MS, namely a decreased abundance of CD141hiIRF8hiCXCR3+CD68- dendritic cells. Unlike in Crohn's disease, no significant differences were found in the monocyte fraction of patients with early MS compared to healthy controls. This study provides a valuable resource for future studies designed to characterise and target diverse PBMC subsets in MS