8 research outputs found
Selective Fabrication of α- and γ-Polymorphs of Glycine by Intense Polarized Continuous Wave Laser Beams
Formation, Dissolution, and Transfer Dynamics of a Millimeter-Scale Thin Liquid Droplet in Glycine Solution by Laser Trapping
Optical Reorientation and Trapping of Nematic Liquid Crystals Leading to the Formation of Micrometer-Sized Domain
Effect of biocompatible nucleants in rapid crystallization of natural amino acids using a CW Nd:YAG laser
Femtosecond Pulse-Width Dependent Trapping and Directional Ejection Dynamics of Dielectric Nanoparticles
Experimental Demonstration of the Carbamazepine Crystallization from Non-photochemical Laser-Induced Nucleation in Acetonitrile and Methanol
International audienceThis paper reports for the first time the crystallization of the carbamazepine (CBZ) molecule in two solvents (methanol and acetonitrile) using the non-photochemical laser-induced nucleation (NPLIN) technique. The metastable zone of CBZ is first determined experimentally for different temperatures in both solvents. Then, the prepared solutions are irradiated by a 532 nm wavelength nanosecond pulsed laser and permitted to obtain CBZ crystals of phases I and III. The impact of laser power and polarization (circularly (CP) and linearly (LP)) on the CBZ crystallization efficiency in both solvents is determined through experiments. According to the results, the crystallization efficiency is significantly higher in methanol than in acetonitrile, and it is higher in solutions irradiated by CP laser than those by LP laser. Moreover, the irradiation of an acetonitrile solution by a LP laser results in CBZ phases I and III, whereas irradiation by the CP laser leads to CBZ phase III crystals. An ab initio determination of the interaction energy of different pairs of CBZ has been carried-out that enables the explanation of the nucleation in acetonitrile for both polarizations. In methanol, only CBZ phase III is obtained, which is in agreement with the ability of methanol to create noncovalent interactions preventing the CBZ phase I and II nucleation