Daunorubicin and gambogic acid co-loaded cysteamine-CdTe quantum dots minimizing the multidrug resistance of lymphoma in vitro and in vivo

To minimize the side effects and the multidrug resistance (MDR) arising from daunorubicin (DNR) treatment of malignant lymphoma, a chemotherapy formulation of cysteamine-modified cadmium tellurium (Cys-CdTe) quantum dots coloaded with DNR and gambogic acid (GA) nanoparticles (DNR-GA-Cys-CdTe NPs) was developed. The physical property, drug-loading efficiency and drug release behavior of these DNR-GA-Cys-CdTe NPs were evaluated, and their cytotoxicity was explored by 3-[4,5-dimethylthiazol-2-y1]-2,5-diphenyltetrazolium bromide assay. These DNR-GA-Cys-CdTe NPs possessed a pH-responsive behavior, and displayed a dose-dependent antiproliferative activity on multidrug-resistant lymphoma Raji/DNR cells. The accumulation of DNR inside the cells, revealed by flow cytometry assay, and the down-regulated expression of P-glycoprotein inside the Raji/DNR cells measured by Western blotting assay indicated that these DNR-GA-Cys-CdTe NPs could minimize the MDR of Raji/DNR cells. This multidrug delivery system would be a promising strategy for minimizing MDR against the lymphoma

A Feasibility Study of Energy Production

This report presents the opportunity for the Ithaca Area Wastewater Treatment Facility (IAWWTF) to maximize its revenue by utilizing the potential of existing Combined Heat and Power (CHP) turbines and exploring other energy sources and their possible implementations. The report also analyzes four different scenarios to maximize revenues for the plant by increasing the capacity of CHP turbines and adding other alternative sources of energy, such as biodiesel, solar photovoltaic and hydro-turbines. This feasibility study is intended for the use of the IAWWTF and professionals interested in producing electricity and heat in a more environmentally friendly way. We hope that our study will help the IAWWTF and the Ithaca communities to reduce their CO2 footprints

Sediment transport partitioning in the swash zone of a large-scale laboratory beach

publisher: Elsevier articletitle: Sediment transport partitioning in the swash zone of a large-scale laboratory beach journaltitle: Coastal Engineering articlelink: http://dx.doi.org/10.1016/j.coastaleng.2015.11.001 content_type: article copyright: © 2015 Elsevier B.V. All rights reserved

QoS Model of WSNs Communication in Smart Distribution Grid

This paper presents an integrated modeling method providing superior Quality of Service (QoS) for wireless sensor networks (WSNs) which is suitable for smart distribution grid (SDG) communication. Traditional QoS model based on IEEE802.15.4 protocol cannot meet the communication requirements of multipriority data in smart distribution grid. In order to meet the specification of power system communication, a new QoS-enabled medium access control (MAC) model based on unfair competition channel access mechanism (UCCAM) is developed in this paper. The proposed model can ensure that the communication system of WSN provides different Qualities of Service for different priority data. According to different requirements for the communication time, the data of SDG are divided into three types: high priority, middle priority, and low priority data. The state transition of buffering queue data in node is described by a three-dimensional Markov chain model. Delay time, effective throughput rate, and channel collision rate models are developed, respectively, to evaluate communication performance of WSN applied in smart distribution grid. The simulation results show that the proposed model can provide different Qualities of Service for different priority data and is more efficient than the IEEE802.15.4e standard and the traditional methods