ESTUDIO QUÍMICO DE LA CORTEZA DE Remijia peruviana “Cascarilla”

En el presente trabajo se realizó el análisis cualitativo de los metabolitos secundarios y la cuantificación e identificación de los alcaloides presentes en la corteza de Remijia peruviana, la cual forma parte de la familia Rubiaceae, caracterizada por sintetizar mayoritariamente alcaloides. Se ha aislado y determinado la estructura química de cinco alcaloides quinolínicos: tres nuevos derivados, Quinina acetato (1), Quinina alcohol (2) y N-Etil Quinina (3); y dos reportados anteriormente en la literatura: Quinina (4) y Cinchonina (5). La estructura de los nuevos alcaloides fueron elucidados por análisis básicos de espectroscopía RMN, incluyendo correlaciones homonuclear y heteronuclear (COSY, NOESY, HMBC y HSQC)

Estudio química de la corteza de Remijia peruviana “Cascarilla”

En el presente trabajo se realizó el análisis cualitativo de los metabolitos secundarios  y la cuantificación e identificación de los alcaloides presentes en la corteza de Remijia peruviana, la cual forma parte de la familia Rubiaceae, caracterizada por sintetizar  mayoritariamente alcaloides. Se ha aislado y determinado la estructura química de cinco alcaloides quinolínicos: tres nuevos derivados, Quinina acetato (1), Quinina alcohol (2) y N-Etil Quinina (3); y dos reportados anteriormente en la literatura: Quinina (4) y Cinchonina (5). La estructura de los nuevos alcaloides fueron elucidados por análisis básicos de espectroscopía RMN, incluyendo correlaciones homonuclear y heteronuclear (COSY, NOESY, HMBC y HSQC)

Absolute configuration of indoline alkaloids from Geissospermum reticulatum

The absolute configuration (AC) of (+)-2R,7R,15R,17S,19S-10-demethoxy-12-hydroxy-17,19-epoxygeissovelline (1), a main aspidospermatan-type indoline alkaloid from Geissospermum reticulatum, was established by vibrational circular dichroism (VCD), facilitating deduction of the AC of all structurally related alkaloids isolated from this plant.This work was partially supported by a Collaborative Research Project (i-COOP2011), CSIC-UNAP, Spain-Perú. W.R.M. thanks MAE-AECID (Spain) for a predoctoral fellowship. Partial financial support from CONACyT-México grant 152994 is appreciated

Bioactive compounds of the genus Senecio from Peruvian Andes

Trabajo presentado en el Congrès International Natural Products and Biocontrol celebrado en Perpignan (Francia) del 24 al 26 de septiembre de 2014.The genus Senecio, is widely distributed throughout the world and consists of approximately 1500 species. This genus is characterized by the presence of pyrrolizidine alkaloids (PAs), sesquiterpenes and diterpenoids. Furthermore, PAs are sequestered by specialist insects for their defense abd chemical communication and are also considered plant defenses against generalist herbivore insects. About 239 species of this genus are present in the Peruvian flora, and several are frequently used in traditional medicine for treatment of diverse diseases.Peer Reviewe

Antiparasitic indole alkaloids from Aspidosperma desmanthum and A. spruceanum from the Peruvian Amazonia

Twenty-three indole alkaloids were isolated from Aspidosperma desmanthum and A. spruceanum. Alkaloids 1-4 were isolated from the leaves, 5-8 from the stem bark and 9-15 from the root bark of A. desmanthum. Alkaloids 5, 11, 16, 17 and 19 were isolated from the stem bark, 18 and 20-22 from the root bark and 23 from the flowers of A. spruceanum. Compounds 4, 14, and 15 have not been previously reported as natural products while 16 and 20 have been isolated for the first time from the genus Aspidosperma. Their structures were determined by spectroscopic techniques including 1D and 2D NMR experiments (COSY, NOESY, HSQC, HMBC). The antiparasitic activity of these compounds was tested against Trypanosoma cruzi and Leishmania infantum and their non-specific cytotoxicity on mammalian cells. The most active compounds were 10, 12, 13, and 14 from A. desmanthum, and 19, 21 and 22 from A. spruceanum. Aspidolimine (10) aspidocarpine (12) and tubotaiwine (21) showed selective activity against L. infantum.This work has been supported by grants CTQ2012-38219-C03-01, MINECO, Spain, and i-COOP0116 (Collaborative Research Project CSIC-UNAP). W.R.M. thanks MAE-AECID, Spain, for a predoctoral fellowship.Peer Reviewe

Benzofurans, benzoic acid derivatives, diterpenes and pyrrolizidine alkaloids from Peruvian Senecio

Sixteen compounds incluiding four benzofurans (1–4), three benzoic acid derivatives (6–8), one eremophilane (9), four diterpenes (10–13) and four pyrrolizidine alkaloids (14–17) were isolated from Senecio subcandidus, S. klugii and S. ayapatensis from Perú. Compounds 1–4 and 6–9 have not been previously reported as natural products. Their molecular structures were determined by NMR spectroscopic analysis, comparison with published NMR data and chemical transformations. The X-ray analysis of acetylated derivative 5 and compound 7 were also performed. Their insecticidal and antifungal activities were tested.This work has been supported by Grant (CTQ2015-64049-C3-1-R) (MINECO/FEDER) Spain. LRV thanks JAEPRE-DOC-CSIC for predoctoral fellowship.Peer Reviewe