Practices and importance of living nobly. The example of Diaz de Escoba in Cordoba

Daily life study will allow us to know, not only the habits and characters from people in the past, but also is an excellent way to understand the strategies for social ascent of certain group of families who chose to emulate the material and immaterial habits of his higher contemporaries in order to be gradually assimilated into the privileged class. This article is about cordobesians Díaz de Escobar who had that wish.El estudio de la vida cotidiana no es sólo una forma como otra cualquiera de acercarse al conocimiento del pasado, analizando cómo vivía y se comportaba, en nuestro caso, la nobleza, sino que también es una excelente plataforma para comprender los mecanismos de ascenso social de determinadas familias que optaron por imitar los hábitos materiales e inmateriales de sus superiores a fin de irse asimilando paulatinamente al estamento privilegiado. Ese es el caso de los cordobeses Díaz de Escobar sobre los que trata el presente artículo

Baseline total metabolic tumor volume is prognostic for refractoriness to Iimunochemotherapy in DLBCL: results from GOYA

Introduction A good response to initial therapy is key to maximizing survival in patients with diffuse large B-cell lymphoma (DLBCL), but patients with chemorefractory disease and early progression have poor outcomes. Patients and Methods Data from the GOYA study in patients with DLBCL who received first-line rituximab or obinutuzumab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) were analyzed. Positron emission tomography/computed tomography (PET/CT)-derived characteristics associated with total metabolic tumor volume (TMTV) and clinical risk factors for primary chemorefractory disease and disease progression within 12 months (POD12) were explored. Results Of those patients fulfilling the criteria for analysis, 108/1126 (10%) were primary chemorefractory and 147/1106 (13%) had POD12. Primary chemorefractory and POD12 status were strongly associated with reduced overall survival. After multivariable analysis of clinical and imaging-based risk factors by backward elimination, only very high TMTV (quartile [Q] 1 vs. Q4 odds ratio [OR]: 0.45; P = .006) and serum albumin levels (low vs. normal OR of 1.86; P = .004) were associated with primary chemorefractoriness. After additionally accounting for BCL2/MYC translocation in a subset of patients, TMTV and BCL2/MYC double-hit status remained as significant predictors of primary chemorefractoriness (Q1 vs. Q4 OR: 0.32, P = .01 and double-hit vs. no-hit OR of 4.47, P = .02, respectively). Risk factors including very high TMTV, high sum of the product of the longest diameters (SPD), geographic region (Asia), short time since diagnosis, extranodal involvement and low serum albumin were retained for POD12. Conclusion PET-derived TMTV has prognostic value in identifying patients at risk of early treatment failure

Transparencia de los procesos de garantía de calidad en la gestión de reclamaciones: estrategias de comunicación y difusión de información a los agentes implicados

Fac. de EducaciónFALSEsubmitte

Fomento de la participación de los diferentes agentes implicados en el SGIC: actualización del material informativo, mejora del espacio web y creación de plataforma de gestión de reclamaciones, quejas, sugerencias y felicitaciones

Es la memoria del Proyecto de Innovación número 126 de la convocatoria 2021-2022, titulado "Fomento de la participación de los diferentes agentes implicados en el SGIC: actualización del material informativo, mejora del espacio web y creación de plataforma de gestión de reclamaciones, quejas, sugerencias y felicitaciones"

Las prácticas del "Vivir Noblemente" y su importancia. El ejemplo de los Díaz de Escobar en Córdoba

Daily life study will allow us to know, not only the habits and characters from people in the past, but also is an excellent way to understand the strategies for social ascent of certain group of families who chose to emulate the material and immaterial habits of his higher contemporaries in order to be gradually assimilated into the privileged class. This article is about cordobesians Díaz de Escobar who had that wish.El estudio de la vida cotidiana no es sólo una forma como otra cualquiera de acercarse al conocimiento del pasado, analizando cómo vivía y se comportaba, en nuestro caso, la nobleza, sino que también es una excelente plataforma para comprender los mecanismos de ascenso social de determinadas familias que optaron por imitar los hábitos materiales e inmateriales de sus superiores a fin de irse asimilando paulatinamente al estamento privilegiado. Ese es el caso de los cordobeses Díaz de Escobar sobre los que trata el presente artículo

Characterization of a Trpc6 Transgenic Mouse Associated with Early Onset FSGS

Mutations in Transient Receptor Potential Channel 6 ( ) gene are associated with autosomal dominant focal and segmental glomerulosclerosis (FSGS). The majority of the identified mutations affect the ion channel function. Since calcium channels are promising candidate drug targets, there is an an urgent need for a mouse model to assess new therapeutic drugs and to help delineate the pathogenic process leading to FSGS. We have previously reported the generation of three independent transgenic mouse lines carrying different Trpc6 mutations that display a glomerular disease comparable to the phenotype presented by individuals with FSGS. However, the utility of these models for drug testing is dampened by the late-onset of the presentation and the mild phenotypic manifestations. In order to obtain a time-effective mouse model for Trpc6-associated FSGS we generated a new transgenic mutant Trpc6 mouse model emulating the amino acid change carried by the first pediatric patient of FSGS associated with a TRPC6 mutation: M132T. Mice carrying the orthologous Trpc6 M131T transgene showed early onset proteinuria and early signs of FSGS. When exploring molecular consequences of the overexpression of this mutated form of Trpc6 in podocytes, differences in expression levels of Axin2 and β-catenin were found in glomeruli from transgenic Trpc6 M131T mice. These data supports the proposed molecular mechanisms related to the activation of calcineurin-NFAT/Wnt signaling, as outcome of the increased calcium influx caused by the mutated form of Trpc6. Given that the Trpc6 M131T mouse develops an early onset of FSGS-like phenotypes it represents a promising model for studying the pathogenesis of FSGS caused by TRpC6, facilitating the assessment of new drugs as treatments and allowing further studies to understand underlying molecular pathways involved in the development of the TRPC6 mediated disease

Baseline total metabolic tumor volume is prognostic for refractoriness to Iimunochemotherapy in DLBCL: results from GOYA

Introduction A good response to initial therapy is key to maximizing survival in patients with diffuse large B-cell lymphoma (DLBCL), but patients with chemorefractory disease and early progression have poor outcomes. Patients and Methods Data from the GOYA study in patients with DLBCL who received first-line rituximab or obinutuzumab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) were analyzed. Positron emission tomography/computed tomography (PET/CT)-derived characteristics associated with total metabolic tumor volume (TMTV) and clinical risk factors for primary chemorefractory disease and disease progression within 12 months (POD12) were explored. Results Of those patients fulfilling the criteria for analysis, 108/1126 (10%) were primary chemorefractory and 147/1106 (13%) had POD12. Primary chemorefractory and POD12 status were strongly associated with reduced overall survival. After multivariable analysis of clinical and imaging-based risk factors by backward elimination, only very high TMTV (quartile [Q] 1 vs. Q4 odds ratio [OR]: 0.45; P = .006) and serum albumin levels (low vs. normal OR of 1.86; P = .004) were associated with primary chemorefractoriness. After additionally accounting for BCL2/MYC translocation in a subset of patients, TMTV and BCL2/MYC double-hit status remained as significant predictors of primary chemorefractoriness (Q1 vs. Q4 OR: 0.32, P = .01 and double-hit vs. no-hit OR of 4.47, P = .02, respectively). Risk factors including very high TMTV, high sum of the product of the longest diameters (SPD), geographic region (Asia), short time since diagnosis, extranodal involvement and low serum albumin were retained for POD12. Conclusion PET-derived TMTV has prognostic value in identifying patients at risk of early treatment failure

Transparency of quality processes: Implementation, analysis of use and improvement of the management platform for complaints-claims, suggestions and congratulations; and evaluation and improvement of web information

El objetivo principal es implementar la plataforma desarrollada en versión piloto durante el curso 2021-2022, analizar su uso y perfeccionar sus características. También analizar y perfeccionar el espacio web de información y dudas frecuentes de la Facultad de Educación- Centro de Formación del Profesorado.UCMDepto. de Investigación y Psicología en EducaciónFac. de EducaciónFALSEsubmitte