342 research outputs found
Dynamic patterns of beta diversity in the Anthropocene: incorporating moderators into dissimilarity-based models
Prevalence of post-traumatic stress disorder among residents of Shanghai standardized training programs during the COVID-19 outbreak: a cross-sectional study
BackgroundThe COVID-19 pandemic may have increased the prevalence of psychiatric disorders, such as anxiety, depressive disorders, and post-traumatic stress disorder (PTSD), among healthcare workers.PurposeThis study aims to investigate the prevalence of PTSD and its risk factors among residents in the standardized residency training programs (SRTPs) in Shanghai during the COVID-19 outbreak.Participants and methodsAn online cross-sectional survey was conducted between December 17, 2021, and January 7, 2022, among SRPT residents from 15 hospitals in Shanghai, China. Questionnaires comprising general information, medical-related traumatic event experiences, the PTSD Checklist (PCL-5), and the perceived social support scale (PSSS) were distributed to the participants using the online Questionnaire Star electronic system.ResultsWe included 835 valid responses for the analysis. In total, 654 residents (78.3%) had experienced at least one traumatic event, and 278 residents (33.3%) were found to have PTSD symptoms. The age 26â30âyears old, female sex, and increased resident working hours were identified as the risk factors for PTSD (pâ<â0.05), and perceived social support had a significant negative association with PTSD (pâ<â0.05).ConclusionDuring the COVID-19 pandemic, there was a high prevalence of PTSD among SRTPs residents in Shanghai. The age 26â30âyears old, female sex, and increased resident working hours were identified as risk factors for PTSD, while perceived social support was identified as a protective factor against PTSD. The present findings can be applied in STRPs management and provide useful information for designing special interventions and protocols for SRTPs residents
JKA97, a Novel Benzylidene Analog of Harmine, Exerts Anti-Cancer Effects by Inducing G1 Arrest, Apoptosis, and p53-Independent Up-Regulation of p21
JKA97, a benzylidene analog of harmine, has been found to be a promising drug candidate for human cancer therapy, although the underlying molecular mechanisms have not been fully demonstrated. In this study, we evaluated the effects of JKA97 on human breast cancer cells in vitro and in vivo. JKA97 inhibited the growth and proliferation of MCF7 (p53 wild-type), MCF7 (p53 knockdown), and MDA-MB-468 (p53 mutant) cells in a dose-dependent manner. Treatment with JKA97 arrested breast cancer cells in G1 phase and induced apoptosis. JKA97 also significantly suppressed the growth of MCF7 and MDA-MB-468 xenograft tumors. It regulated the expression levels of G1 phase regulators, such as p21, p27, cyclinE, and cylinD1. JKA97 activated p21 transcription, independent of p53, but had little effect on p21 protein stability/degradation. In summary, our results suggest that JKA97 inhibits human breast cancer cell growth through activating p21, independent of p53, which provides a basis for developing this compound as a novel drug for human breast cancer therapy
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
Study of the decay
The decay is studied
in proton-proton collisions at a center-of-mass energy of TeV
using data corresponding to an integrated luminosity of 5
collected by the LHCb experiment. In the system, the
state observed at the BaBar and Belle experiments is
resolved into two narrower states, and ,
whose masses and widths are measured to be where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt sample. Evidence of a new
state is found with a local significance of , whose mass and width
are measured to be and , respectively. In addition, evidence of a new decay mode
is found with a significance of
. The relative branching fraction of with respect to the
decay is measured to be , where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
Measurement of the ratios of branching fractions and
The ratios of branching fractions
and are measured, assuming isospin symmetry, using a
sample of proton-proton collision data corresponding to 3.0 fb of
integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The
tau lepton is identified in the decay mode
. The measured values are
and
, where the first uncertainty is
statistical and the second is systematic. The correlation between these
measurements is . Results are consistent with the current average
of these quantities and are at a combined 1.9 standard deviations from the
predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb
public pages
PGC-1α is associated with Schizothorax prenanti myoblast differentiation
PGC-1α has been considered as an important mediator of functional capacity of muscle. Our previous study indicated that the mRNA level of PGC-1α increased in muscle during Schizothorax prenanti (S. prenanti) growth. To understand the biological significance of PGC-1α up-regulation, S. prenanti myosatellite cells were isolated and the function of PGC-1α in myoblast differentiation was further investigated. The results indicated that PGC-1α over-expressing transfectants fused to form myotubes with higher mRNA level of myosin heavy chain isoform I (MyHCI). No obvious differentiation was observed in PGC-1α-targeted shRNA-transfected cells with a marked decrement of MyHCI expression. Furthermore, S. prenanti PGC-1α increased the expression of MyoD and MyoG, which controlled the commitment of precursor cells to myotubes. In contrast, the levels of MyoD and MyoG mRNA were down-regulated with shRNA-targeting PGC-1α transfection. These investigations indicate that PGC-1α is associated with myoblast differentiation and it elevates MyoD and MyoG expression levels in S. prenanti myoblast cells
Highly Efficient Oxidative Dimerization of Thioamides to 3,5-Disubstituted 1,2,4-Thiadiazoles Mediated by DDQ
Additive Manufactured Large Zr-Based Bulk Metallic Glass Composites with Desired Deformation Ability and Corrosion Resistance
Zr-based bulk metallic glasses have been attracting tremendous interest of researchers because of their unique combination of mechanical and chemical properties. However, their application is limited as large-scale production is difficult due to the limitation of cooling rate. Recently, additive manufacturing technology has been proposed as a new solution for fabricating bulk metallic glasses without size limitation. In this study, selective laser melting technology was used to prepare Zr60Fe10Cu20Al10 bulk metallic glass. The laser parameters for fabricating full dense amorphous specimens were investigated. The mechanical and corrosion resistance properties of the prepared samples were measured by micro-compression and electrochemical corrosion testing, respectively. Lastly, Zr60Fe10Cu20Al10 bulk metallic glass (BMG) with dispersed nano-crystals was made, and good deformation ability was revealed during micro-compression test. The corrosion resistance decreased a bit due to the crystalline phases. The results provide a promising route for manufacturing large and complex bulk metallic glasses with better mechanical property and acceptable corrosion resistance
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