3 research outputs found
Synthesis of <i>o</i>‑Methyl Trifluoromethyl Sulfide Substituted Benzophenones via 1,2-Difunctionalization of Aryne by Insertion into the C–C Bond
An efficient process
for the preparation of valuable <i>o</i>-methyl trifluoromethyl
sulfide substituted benzophenones has been
developed. The transition-metal-free method features insertion of
aryne into a C–C σ-bond under mild reaction conditions
for the first time to achieve <i>ortho</i>-difunctionalized
arenes containing a pharmaceutically important trifluoromethylthio
functional group. A wide substrate scope has been demonstrated for
the developed protocol