British digital game studies

This paper provides a short and potted recent history of digital games research in Great Britain. We begin this story in 2001. Though a substantial amount of research and writing on digital games was taking in Britain since at least the 1980s, for us the turn of the new millennium makes a logical starting point for our recent history. This is because this was not only the year that Aarseth (2001) marked as 'year one' for 'computer game research', but it was also the year that the first major international conference on digital games took place in the UK (in Bristol), and the first time a major British government grant was awarded to undertake research on digital gaming. The paper then charts the significant role Britain played in hosting major early international gatherings of (now leading) games researchers, such as those in Bristol and also Manchester. As well as the important crop of early British authored (text)books that helped shape the direction of this new emerging discipline. What we then see is a significant growth in British digital games studies focused around a number of key events, research clusters, and publications, and the development of a particular framing of digital games within a wider social, cultural, and political context. It is this, we would suggest, which has given British digital game studies its particular flavour and also its important global role in pushing forward research, theory, and key debates

Topics on the geometry of D-brane charges and Ramond-Ramond fields

In this paper we discuss some topics on the geometry of type II superstring backgrounds with D-branes, in particular on the geometrical meaning of the D-brane charge, the Ramond-Ramond fields and the Wess-Zumino action. We see that, depending on the behaviour of the D-brane on the four non-compact space-time directions, we need different notions of homology and cohomology to discuss the associated fields and charge: we give a mathematical definition of such notions and show their physical applications. We then discuss the problem of corretly defining Wess-Zumino action using the theory of p-gerbes. Finally, we recall the so-called *-problem and make some brief remarks about it.Comment: 29 pages, no figure

Regression of murine lung tumors by the let-7 microRNA.

MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human diseases, including cancer. Here, we show that loss of let-7 function enhances lung tumor formation in vivo, strongly supporting the hypothesis that let-7 is a tumor suppressor. Moreover, we report that exogenous delivery of let-7 to established tumors in mouse models of non-small-cell lung cancer (NSCLC) significantly reduces the tumor burden. These results demonstrate the therapeutic potential of let-7 in NSCLC and point to miRNA replacement therapy as a promising approach in cancer treatment

Fly fishing no-kill zones: a possible way to conjugate conservation issues, sustainable sport enhancement and local development in Alpine areas?

The promotion of sustainable tourism and outdoor sports can represent an important way to couple environmental conservation strategies and economic enhancement in marginal and Alpine areas. In this context catch and release fly fishing zones can represent an interesting tool, although no data is available on the effectiveness of these practices on Alpine salmonid population dynamics. Salmonids are the main group of fish in alpine rivers and they are the only actively targeted by anglers. Aim of this work is filling this gap, with a pilot study on two no-kill zones (Po and Pellice rivers, NW Italy). We conducted a temporal and spatial comparison between free-fishing and catch and release management river sections, with a detailed analysis on the Po River site. Our results support the hypothesis that catch and release management allows a numerical increase in wild trout populations. In particular, we detected a massive and rapid increase in younger individuals, possibly linked to a stop on the removal of large-sized reproducers. Protecting trout by the implementation of this practice can at the same time allow the increase of sustainable economic development and sport in marginal areas

DIGITAL TECHNOLOGIES FOR INCLUSIVE CULTURAL HERITAGE: THE CASE STUDY OF SERRALUNGA D'ALBA CASTLE

Abstract. Natural sites, monuments and historical artefacts are Cultural Heritage that must be properly managed to ensure their safeguard. Institutions and corporate body devoted to the Cultural Heritage management have the essential task of supervising them paying particular attention to their conservation, dissemination and fruition. In this regards, digital technologies through ICT (Information and Communication Technologies) and New Media represent useful tools which have to be used in suitable way. In this context, this contribution shares the methodology adopted for the case study of Serralunga d'Alba castle. In particular, the research project shows the process used for getting the digital model of the castle through HBIM (Historic Building Information Modeling) methodology and the development of a VR (Virtual Reality) model tour. The final project obtained is the result of a methodological approach that aimed to optimize time, costs and efforts.</p

Etiological diagnosis, prognostic significance and role of electrophysiological study in patients with Brugada ECG and syncope.

BACKGROUND: Syncope is considered a risk factor for life-threatening arrhythmias in Brugada patients. Distinguishing a benign syncope from one due to ventricular arrhythmias is often difficult, unless an ECG is recorded during the episode. Aim of the study was to analyze the characteristics of syncopal episodes in a large population of Brugada patients and evaluate the role of electrophysiological study (EPS) and the prognosis in the different subgroups. METHODS AND RESULTS: One hundred ninety-five Brugada patients with history of syncope were considered. Syncope were classified as neurally mediated (group 1, 61%) or unexplained (group 2, 39%) on the basis of personal and family history, clinical features, triggers, situations, associated signs, concomitant therapy. Most patients underwent EPS; they received ICD or implantable loop-recorder on the basis of the result of investigations and physician's judgment. At 62±45months of mean follow-up, group 1 showed a significantly lower incidence of arrhythmic events (2%) as compared to group 2 (9%, p<0.001). Group 2 patients with positive EPS showed the highest risk of arrhythmic events (27%). No ventricular events occurred in subjects with negative EPS. CONCLUSION: Etiological definition of syncope in Brugada patients is important, as it allows identifying two groups with different outcome. Patients with unexplained syncope and ventricular fibrillation induced at EPS have the highest risk of arrhythmic events. Patients presenting with neurally mediated syncope showed a prognosis similar to that of the asymptomatic and the role of EPS in this group is unproven