A Streaming Algorithm for the Convex Hull

Consider a base station in a wireless sensor network that receives incoming input points and must maintain a running convex hull within a memory constraint. We give a new streaming algorithm that processes each point in time O (log k) where k is the memory constraint, while maintaining an optimal area error of O(1/k²)

Perceptions on Tsetse and Trypanosomosis Disease among Livestock Marketers at Wudil Cattle Market, Wudil, Kano

African Animal Trypanosomosis (AAT) is a debilitating disease that hinders livestock productivity in Nigeria and sub-Saharan Africa. Numerous strategies have been developed over time to fight this devastating disease, which are emphasized mostly on containing the spread of its causative agent and principal vector. However, very little has been done to include livestock marketers in decision making, planning and implementation of control programs. Therefore, this study was carried out to fill that void, by evaluating the knowledge of this group of people on Tsetsefly and Trypanosomosis in Wudil Cattle Market. Questionnaires were developed to collect relevant information, and were administered through ‘Standard Focus Group Discussions’. The results revealed that tsetse fly was known by all respondents (100%), who significantly reported that they were most commonly found in the forests (95%), during the wet season (85%). Respondents also reported that these flies prefer to bite animals (71.25%). Similarly, a majority of respondents (97.5%) reported to being cognizant of trypanosomosis disease, while also stating that it had infected their animals at some point in time. Respondents believed infection was most prevalent during the wet season (60%) than the dry season (40%). Respondents had mixed views when it came to perceived causes of the disease, as some associated it with bite from flies (53.75%), while others linked it to transhumance (38.75%). In terms of signs and symptoms, 80% of respondents were able to identify with at least four symptoms of the disease. In essence, this study further intensifies the need to engage livestock marketers in tsetse and trypanosomosis control programs, in addition to emphasizing the need to create awareness campaigns that can further limit the spread of the disease and ensure vector control

Health system barriers influencing timely breast cancer diagnosis and treatment among women in low and middle-income Asian countries: evidence from a mixed-methods systematic review.

Globally, breast cancer is the most common cancer type and the leading cause of cancer mortality among women in developing countries. A high prevalence of late breast cancer diagnosis and treatment has been reported predominantly in Low- and Middle-Income Countries (LMICs), including those in Asia. Thus, this study utilized a mixed-methods systematic review to synthesize the health system barriers influencing timely breast cancer diagnosis and treatment among women in Asian countries. We systematically searched five electronic databases for studies published in English from 2012 to 2022 on health system barriers that influence timely breast cancer diagnosis and treatment among women in Asian countries. The review was conducted per the methodology for systematic reviews and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, while health system barriers were extracted and classified based on the World Health Organization (WHO)'s Health Systems Framework. The mixed-methods appraisal tool was used to assess the methodological quality of the included studies. Twenty-six studies were included in this review. Fifteen studies were quantitative, nine studies were qualitative, and two studies used a mixed-methods approach. These studies were conducted across ten countries in Asia. This review identified health systems barriers that influence timely breast cancer diagnosis and treatment. The factors were categorized under the following: (1) delivery of health services (2) health workforce (3) financing for health (4) health information system and (5) essential medicines and technology. Delivery of health care (low quality of health care) was the most occurring barrier followed by the health workforce (unavailability of physicians), whilst health information systems were identified as the least barrier. This study concluded that health system factors such as geographical accessibility to treatment, misdiagnosis, and long waiting times at health facilities were major barriers to early breast cancer diagnosis and treatment among Asian women in LMICs. Eliminating these barriers will require deliberate health system strengthening, such as improving training for the health workforce and establishing more healthcare facilities. [Abstract copyright: © 2022. The Author(s).

Strain elastography for noninvasive assessment of liver fibrosis: A prospective study with histological comparison

The aim of this study was to prospectively evaluate the diagnostic performance of strain elastography for the assessment of liver fibrosis in patients with chronic liver disease using Ishak (0–6) histology stage as a reference standard. Ninety-eight consecutive patients with suspected chronic liver disease scheduled for liver biopsy (n = 78) or histologically confirmed cirrhosis (n = 20) were enrolled. Liver fibrosis Index (LF Index) calculated by strain elastography, liver stiffness by transient elastography and serum fibrosis markers (aspartate aminotransferase-to-platelet ratio index and King’s Score) were measured. Spearman’s correlation coefficient between the LF Index, liver stiffness, serum fibrosis markers and fibrosis stage were calculated and compared using areas under the receiver-operating characteristics (AUROCs) curves. Among 73 patients who underwent strain elastography, there was weak correlation between fibrosis stage and the LF Index (Spearman’s: ρ = 0.385 for Ishak score; P = 0.001). Among 52 patients who underwent strain elastography and transient elastography, the AUROC values using LF Index, transient elastography, aspartate aminotransferase-to-platelet ratio index and King’s Score for diagnosing significant fibrosis (Ishak score ≥ 3) were 0.79, 0.87, 0.86 and 0.85, respectively (P < 0.0001) and for diagnosing severe fibrosis/cirrhosis (Ishak score ≥ 5) were 0.83, 0.94, 0.92 and 0.92, respectively (P < 0.0001). When comparing the diagnostic performance using LF Index, transient elastography, aspartate aminotransferase-to-platelet ratio index and King’s Score, transient elastography shows a significantly higher AUROC value than LF Index in detecting severe fibrosis (P = 0.0149). The diagnostic performance of LF Index calculated by strain elastography was not statistically significantly different to the other noninvasive tests for the assessment of significant liver fibrosis but inferior to transient elastography for the assessment of severe fibrosis/cirrhosis

Enhancing moringa nutritive value for impoverished populations and healthy wellbeing through proper nutrient enrichment

Taking into account the many cases of malnutrition related deaths in especially sub-Saharan Africa, the current research effort was conceived with the objective of appraising the nutritive potential of Moringa oleifera L. plant through the evaluation of proper agronomic practice that will enhance its nutritive potential. Measured quantity of dried roots, stem, and leaves portions of 5 months old Moringa oleifera L. seedlings, grown under various applied phosphorus (P) and potassium (K) rates were analysed for essential and non-essential amino acids content, total antioxidants, secondary metabolites (phenolics and flavonoids), and mineral nutrient elements. The high-performance liquid chromatography (HPLC) analysis revealed the presence of 9 essential and 7 non-essential amino acids, with a range of 4.24 to 10.04 gkg-1 recorded for leucine, threonine, histidine, glutamic acid, aspartic acid, and glycine. The 2,2ꞌ- diphenyl-1-picrylhydrazyl (DPPH) and the ferric reducing antioxidant power (FRAP) assay revealed strong antioxidants presence (up to 68% DPPH scavenging activity and a high level FRAP potential of 2500 mg ascorbic acid equivalent (AAE) / 100g dry weight (DW). Folin-Ciocalteu’s and aluminium chloride calorimetric assay revealed high levels of secondary metabolites (ranging from 1000 to 1350 mg gallic acid equivalent (GAE)/100g DW total phenolics and up to 2400 mg quercetin equivalent (QE)/1mg DW total flavonoids), and the nitric acid wet digestion procedure revealed a lot of mineral nutrient elements (with significant values of up to 19.13 g kg-1 maximum content acquired from calcium (Ca) and up to 9.90 g kg-1 recorded for iron (Fe). These nutritive components are noted to be highest in the leaves portion, followed by the roots, and then the stem parts. Based on its recognised rich base nutritive content, Moringa oleifera L. is a tree plant of nutraceuticals importance for impoverished communities

Enthesis tissue engineering: biological requirements meet at the interface

Tendon-to-bone interface (enthesis) exhibits a complex multiscale architectural and compositional organization maintained by a heterogeneous cellular environment. Orthopedic surgeons have been facing several challenges when treating tendon pullout or tear from the bony insertion due to unsatisfactory surgical outcomes and high retear rates. The limited understanding of enthesis hinders the development of new treatment options toward enhancing regeneration. Mimicking the natural tissue structure and composition is still a major challenge to be overcome. In this review, we critically assess current tendon-to-bone interface tissue engineering strategies through the use of biological, biochemical, or biophysical cues, which must be ultimately combined into sophisticated gradient systems. Cellular strategies are described, focusing on cell sources and cocultures to emulate a physiological heterotypic niche, as well as hypoxic environments, alongside with growth factor delivery and the use of platelet-rich hemoderivatives. Biomaterial design considerations are revisited, highlighting recent progresses in tendon-to-bone scaffolds. Mechanical loading is addressed to uncover prospective engineering advances. Finally, research challenges and translational aspects are considered. In summary, we highlight the importance of deeply investigating enthesis biology toward establishing foundational expertise and integrate cues from the native niche into novel biomaterial engineering, aiming at moving today's research advances into tomorrow's regenerative therapies.Authors thank the support from the European Union Framework Programme for Research and Innovation HORIZON2020 [TEAMING Grant agreement No 739572 - The Discoveries CTR]; FCT–Fundação para a Ciência e a Tecnologia for the PhD grant of IC [PD/BD/128088/2016]; the Project NORTE-01-0145-FEDER-000021:“Accelerating tissue engineering and personalized medicine discoveries by the integration of key enabling nanotechnologies, marine-derived biomaterials and stem cells”, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and the ERC Consolidator grant of ME [ERC-2017-CoG-772817]

Electrophysiological and fundoscopic detection of intracranial hypertension in craniosynostosis

Aims: To assess the diagnostic accuracy of fundoscopy and visual evoked potentials (VEPs) in detecting intracranial hypertension (IH) in patients with craniosynostosis undergoing spring-assisted posterior vault expansion (sPVE). Methods: Children with craniosynostosis undergoing sPVE and 48-hour intracranial pressure (ICP) monitoring were included in this single-centre, retrospective, diagnostic accuracy study. Data for ICP, fundoscopy and VEPs were analysed. Primary outcome measures were papilloedema on fundoscopy, VEP assessments and IH, defined as mean ICP &gt; 20 mmHg. Diagnostic indices were calculated for fundoscopy and VEPs against IH. Secondary outcome measures included final visual outcomes. Results: Fundoscopic examinations were available for 35 children and isolated VEPs for 30 children, 22 of whom had at least three serial VEPs. Sensitivity was 32.1% for fundoscopy (95% confidence intervals [CI]: 15.9–52.4) and 58.3% for isolated VEPs (95% CI 36.6–77.9). Specificity for IH was 100% for fundoscopy (95% CI: 59.0–100) and 83.3% for isolated VEPs (95% CI: 35.9–99.6). Where longitudinal deterioration was suspected from some prVEPs but not corroborated by all, sensitivity increased to 70.6% (95% CI: 44.0–89.7), while specificity decreased to 60% (95% CI: 14.7–94.7). Where longitudinal deterioration was clinically significant, sensitivity decreased to 47.1% (23.0–72.2) and specificity increased to 100% (47.8–100). Median final BCVA was 0.24 logMAR (n = 36). UK driving standard BCVA was achieved by 26 patients (72.2%), defined as ≥0.30 logMAR in the better eye. Conclusion: Papilloedema present on fundoscopy reliably indicated IH, but its absence did not exclude IH. VEP testing boosted sensitivity at the expense of specificity, depending on method of analysis.</p