3,818 research outputs found
Quantifying electronic correlation strength in a complex oxide: a combined DMFT and ARPES study of LaNiO
The electronic correlation strength is a basic quantity that characterizes
the physical properties of materials such as transition metal oxides.
Determining correlation strengths requires both precise definitions and a
careful comparison between experiment and theory. In this paper we define the
correlation strength via the magnitude of the electron self-energy near the
Fermi level. For the case of LaNiO, we obtain both the experimental and
theoretical mass enhancements by considering high resolution
angle-resolved photoemission spectroscopy (ARPES) measurements and density
functional + dynamical mean field theory (DFT + DMFT) calculations. We use
valence-band photoemission data to constrain the free parameters in the theory,
and demonstrate a quantitative agreement between the experiment and theory when
both the realistic crystal structure and strong electronic correlations are
taken into account. These results provide a benchmark for the accuracy of the
DFT+DMFT theoretical approach, and can serve as a test case when considering
other complex materials. By establishing the level of accuracy of the theory,
this work also will enable better quantitative predictions when engineering new
emergent properties in nickelate heterostructures.Comment: 10 pages, 5 figure
Plant roots steer resilience to perturbation of river floodplains
Freshwater ecosystems along river floodplains host among the greatest biodiversity on Earth and are known to respond to anthropic pressure. For water impounded systems, resilience to changes in the natural flow regime is believed to be bi-directional. Whether such resilience prevents the system from returning to pristine conditions after the flow regime changes reverse is as yet unclear, though widely documented. In this work we show that temporal irreversibility of river floodplains to recover their status may be explained by the dynamics of riparian water-tolerant plant roots. Our model is a quantitative tool that will benefit scientists and practitioners in predicting the impact of changing flow regimes on long-term river floodplain dynamics
Interplay of Spin-Orbit Interactions, Dimensionality, and Octahedral Rotations in Semimetallic SrIrO
We employ reactive molecular-beam epitaxy to synthesize the metastable
perovskite SrIrO and utilize {\it in situ} angle-resolved photoemission
to reveal its electronic structure as an exotic narrow-band semimetal. We
discover remarkably narrow bands which originate from a confluence of strong
spin-orbit interactions, dimensionality, and both in- and out-of-plane IrO
octahedral rotations. The partial occupation of numerous bands with strongly
mixed orbital characters signals the breakdown of the single-band Mott picture
that characterizes its insulating two-dimensional counterpart,
SrIrO, illustrating the power of structure-property relations for
manipulating the subtle balance between spin-orbit interactions and
electron-electron interactions
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Mycolactone-dependent depletion of endothelial cell thrombomodulin is strongly associated with fibrin deposition in Buruli ulcer lesions
A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone. Since the underlying mechanism is not known, we have investigated the effect of mycolactone on endothelial cells, focussing on the expression of surface anticoagulant molecules involved in the protein C anticoagulant pathway. Congenital deficiencies in this natural anticoagulant pathway are known to induce thrombotic complications such as purpura fulimans and spontaneous necrosis. Mycolactone profoundly decreased thrombomodulin (TM) expression on the surface of human dermal microvascular endothelial cells (HDMVEC) at doses as low as 2ng/ml and as early as 8hrs after exposure. TM activates protein C by altering thrombin's substrate specificity, and exposure of HDMVEC to mycolactone for 24 hours resulted in an almost complete loss of the cells' ability to produce activated protein C. Loss of TM was shown to be due to a previously described mechanism involving mycolactone-dependent blockade of Sec61 translocation that results in proteasome-dependent degradation of newly synthesised ER-transiting proteins. Indeed, depletion from cells determined by live-cell imaging of cells stably expressing a recombinant TM-GFP fusion protein occurred at the known turnover rate. In order to determine the relevance of these findings to BU disease, immunohistochemistry of punch biopsies from 40 BU lesions (31 ulcers, nine plaques) was performed. TM abundance was profoundly reduced in the subcutis of 78% of biopsies. Furthermore, it was confirmed that fibrin deposition is a common feature of BU lesions, particularly in the necrotic areas. These findings indicate that there is decreased ability to control thrombin generation in BU skin. Mycolactone's effects on normal endothelial cell function, including its ability to activate the protein C anticoagulant pathway are strongly associated with this. Fibrin-driven tisischemia could contribute to the development of the tissue necrosis seen in BU lesions
Case series on granulosa cell tumour in cattle with practical hints on diagnostics and outcome
Granulosa cell tumours are the most common neoplasm of the bovine ovary and present with a wide range of clinical signs. This case series comprises five case reports of ovarian granulosa cell tumours in cattle. The affected animals had different breeds (Red Holstein, Eringer, Swiss Braunvieh, crossbred beef) and ranged in age from 1 year 4 months to 20 years 11 months. The diversity of the cases gives an overview of the diagnostic possibilities as well as the possible treatments and outcomes of the disease. Anti-mullerian hormone (AMH) was measured in one of the affected animals, and was extremely elevated (>150 pmoL/L) compared to reported normal values (<3 pmoL/L). Three animals underwent standing laparotomy with unilateral ovariectomy, and the remaining two animals were slaughtered. One of the cases confirms the previously published reports that malignancy or metastasis is possible in cattle. Another case indicates that successful surgical treatment with subsequent resumption of reproduction is possible. In summary, the initial tentative diagnosis of GCT is made by ultrasound-assisted rectal examination of the genital tract or ovaries and can subsequently be supported by evaluation of AMH levels. The decision to proceed with treatment should be made without delay, as surgical removal of the altered ovary with subsequent resumption of reproductive activity and cessation of undesirable behaviour is possible
Exact Boundary Critical Exponents and Tunneling Effect in Integrable Models for Quantum Wires
Using the principles of the conformal quantum field theory and the finite
size corrections of the energy of the ground and various excited states, we
calculate the boundary critical exponents of single- and multicomponent Bethe
ansatz soluble models. The boundary critical exponents are given in terms of
the dressed charge matrix which has the same form as that of systems with
periodic boundary conditions and is uniquely determined by the Bethe ansatz
equations. A Luttinger liquid with open boundaries is the effective low-energy
theory of these models. As applications of the theory, the Friedel oscillations
due to the boundaries and the tunneling conductance through a barrier are also
calculated. The tunneling conductance is determined by a nonuniversal boundary
exponent which governs its power law dependence on temperature and frequency.Comment: REVTEX, submitted to PR
Microbiological, histological, immunological, and toxin response to antibiotic treatment in the mouse model of Mycobacterium ulcerans disease.
Mycobacterium ulcerans infection causes a neglected tropical disease known as Buruli ulcer that is now found in poor rural areas of West Africa in numbers that sometimes exceed those reported for another significant mycobacterial disease, leprosy, caused by M. leprae. Unique among mycobacterial diseases, M. ulcerans produces a plasmid-encoded toxin called mycolactone (ML), which is the principal virulence factor and destroys fat cells in subcutaneous tissue. Disease is typically first manifested by the appearance of a nodule that eventually ulcerates and the lesions may continue to spread over limbs or occasionally the trunk. The current standard treatment is 8 weeks of daily rifampin and injections of streptomycin (RS). The treatment kills bacilli and wounds gradually heal. Whether RS treatment actually stops mycolactone production before killing bacilli has been suggested by histopathological analyses of patient lesions. Using a mouse footpad model of M. ulcerans infection where the time of infection and development of lesions can be followed in a controlled manner before and after antibiotic treatment, we have evaluated the progress of infection by assessing bacterial numbers, mycolactone production, the immune response, and lesion histopathology at regular intervals after infection and after antibiotic therapy. We found that RS treatment rapidly reduced gross lesions, bacterial numbers, and ML production as assessed by cytotoxicity assays and mass spectrometric analysis. Histopathological analysis revealed that RS treatment maintained the association of the bacilli with (or within) host cells where they were destroyed whereas lack of treatment resulted in extracellular infection, destruction of host cells, and ultimately lesion ulceration. We propose that RS treatment promotes healing in the host by blocking mycolactone production, which favors the survival of host cells, and by killing M. ulcerans bacilli
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