When It’s Okay That I Don’t Play: Social Norms and the Situated Construal of Social Exclusion

Being excluded and ignored has been shown to threaten fundamental human needs and cause pain. Such reflexive reactions to social exclusion have been conceptualized as direct and unmoderated (temporal need threat model of ostracism). Here, we propose an extension and argue that reflexive reactions depend on how social exclusion situations are construed. If being excluded is understood as a violation of an inclusion norm, individuals will react with pain and threat. In contrast, if being excluded is consistent with the prevailing norm, the exclusion situation is interpreted as less threatening, and negative reflexive reactions to ostracism should be attenuated. Four studies empirically support this conceptual model. Studies 3 and 4 further show that to guide situated construal, the norm has to be endorsed by the individual. In both Studies 1 and 3, the effect of the norm is mediated by the objective situation’s subjective construal

Lattice and thermodynamic characteristics of N-stearoyl-allo-threonine monolayers

The effect of the second chiral center of diastereomeric N-alkanoyl-allo-threonine on the main monolayer characteristics has been investigated. The characteristic features of the enantiomeric and racemic forms of N-stearoyl-allo-threonine monolayers are studied on a thermodynamic basis and molecular scale. The π–A curves of the enantiomeric and racemic allo-forms show similar features to those of N-stearoyl-threonine. The compression curves are always located above the corresponding decompression curves and the decompression curves can be used as equilibrium isotherms for both the enantiomeric and racemic N-stearoyl-allo-threonine. The absolute T0-values (disappearance of the LE/LC-transition) are 4–5 K larger compared with the corresponding N-stearoyl-threonines,} but the ΔT0 between the enantiomeric (d) and the racemic (dl) forms is only slightly larger than that of N-stearoyl-threonine. The difference in the critical temperatures Tc{,} above which the monolayer cannot be compressed into the condensed state{,} between the enantiomeric and the racemic forms{,} is quite small (ΔTc = 0.8 K) and is smaller compared to that of the corresponding threonines (ΔTc = 1.8 K). This is consistent with the dominance of the van der Waals interactions between the alkyl chains reducing the influence of chirality on the thermodynamic parameters. GIXD studies of N-stearoyl-allo-threonine monolayers provide information about the lattice structure of condensed monolayer phases on the Angstrom scale and stipulate the homochiral or heterochiral preference in the condensed phases. Comparable to N-stearoyl-threonine{,} the enantiomers exhibit an oblique lattice structure{,} whereas the racemates form a NNN tilted orthorhombic structure demonstrating the dominance of heterochiral interactions in the racemates independent of the diasteomeric structure change of the polar head group. The A0 values are characteristic for rotator phases. The smaller A0 value obtained for the racemic monolayers indicates their tighter packing caused by heterochiral interactions. The program Hardpack was used to predict the geometric parameters of possible 2-dimensional packings. For comparison with the experimental GIXD data{, the two-dimensional lattice parameters and characteristic features of the enantiomeric and racemic diastereomeric stearoyl-threonine monolayers were calculated and are in reasonable agreement with the experimental GIXD data

Intra- and Interspecies Analyses of the Carcinoembryonic Antigen (CEA) Gene Family Reveal Independent Evolution in Primates and Rodents

Various rodent and primate DNAs exhibit a stronger intra- than interspecies cross-hybridization with probes derived from the N-terminal domain exons of human and rat carcinoembryonic antigen (CEA)-like genes. Southern analyses also reveal that the human and rat CEA gene families are of similar complexity. We counted at least 10 different genes per human haploid genome. In the rat, approximately seven to nine different N-terminal domain exons that presumably represent different genes appear to be present. We were able to assign the corresponding genomic restriction endonuclease fragments to already isolated CEA gene family members of both human and rat. Highly similar subgroups, as found within the human CEA gene family, seem to be absent from the rat genome. Hybridization with an intron probe from the human nonspecific cross-reacting antigen (NCA) gene and analysis of DNA sequence data indicate the conservation of noncoding regions among CEA-like genes within primates, implicating that whole gene units may have been duplicated. With the help of a computer program and by calculating the rate of synonymous substitutions, evolutionary trees have been derived. From this, we propose that an independent parallel evolution, leading to different CEA gene families, must have taken place in, at least, the primate and rodent orders

Ubiquitous Nuclear Factors Bind Specifically to a 5′-Region Conserved in Carcinoembryonic Antigen-Related Genes

We recently cloned members of the murine carcinoembryonic antigen (CEA) gene family, some of which are differentially expressed during placental development. By intra- and interspecies sequence comparisons, we identified an element in the putative promoter and/or 5′-nontranslated region which is conserved within all human and rodent CEA-related genes analyzed so far. Using gel retardation analysis and DNasel hypersensitive site mapping, we now show that ubiquitously expressed nuclear factors specifically bind to the conserved region derived from the mouse gene Cea-2 in vitro and probably also in vivo. Another DNasel hypersensitive site lies within or close to a simple sequence motif [(GGA)n] located in the first intron of Cea-2. Such sequences have been reported to play a role in the regulation of certain genes. Therefore, this analysis has identified putative regulatory regions for Cea-2 and possibly CEA-related genes in general

She\u27s an All-in-One Guru : Devotion to a 21st century Mystic

Anandmurti Gurumaa is a multi-lingual teacher of meditation and spirituality situated at the intersection of Hindu, Buddhist, Sufi and Sikh mystical traditions. This dissertation, employing inter-disciplinary methodology, provides an in-depth study of Gurumaa and her rapidly developing, disciple-driven transnational spiritual movement. I introduce Gurumaa and her circle of devotees within the cultural context of globetrotting Indian gurus and examine issues of tradition and innovation in her mission. Through ethnographic writing, I specifically turn to examples of Gurumaa\u27s pluralism, gender activism and embrace of new media to discuss continuity and change within the tradition of guru-bhakti (devotion to the guru). Because Gurumaa embraces rhetoric of female empowerment, and points to her own enlightened female body as evidence that women can and do reach the highest spiritual states, her leadership offers an ideal context in which to consider emerging gendered re-interpretations of tradition in the new global religious milieu

On the complexity of the economic lot-sizing problem with rework of defectives

In this paper, we will show that the economic lot-sizing problem with rework of defectives is NP-hard. Therefore, we reduce it to the well-known PARTITION problem. This is in line with the findings for similar models that in-vestigate lot-sizing with remanufacturing

Why didn't you tag me?!: Social exclusion from Instagram posts hurts, especially those with a high need to belong

Humans are highly sensitive to ostracism experiences and thus, even very short occurrences of being excluded and ignored can threaten fundamental needs and lower mood. We investigated whether not being tagged causes similar negative responses as being excluded in real life. Using a multi-method approach, we show across five studies (total N = 1149) that not being tagged in a posted photo strongly threatens fundamental needs. This effect is moderated by individuals' need to belong, such that individuals with a higher need to belong experience not being tagged as more aversive. Results replicate across vignette studies in which participants imagine not being tagged on Instagram (Studies 2 and 3) and across studies using an alleged group task paradigm that mimicked the psychological mechanism of not being tagged outside of Instagram (Studies 4a and 4b). All experimental studies were pre-registered and we freely share all materials, code and data. Extending ostracism effects to the social media phenomenon tagging, the present research bridges real-world and digital social interactions. The results add to theoretical knowledge on social media, ostracism, and digital well-being and have practical implications for social media app design, social media interventions and our everyday interactions that increasingly happen online

You should go for diversity, but I'd rather stay with similar others: Social distance modulates the preference for diversity

Organizations often state that they value diversity. The workforce, however, is often quite homogeneous, reflecting a striking mismatch between aspirations and reality. Based on the distinction between desirability and feasibility concerns, we provide a psychological argument for this mismatch. We hypothesize that social distance influences individuals' choices regarding diversity. When being socially more distant, individuals prefer to assemble a diverse team, due to a stronger impact of pro-diversity desirability concerns. In contrast, when being socially close, individuals prefer similar team members, due to a stronger weighing of anti-diversity feasibility concerns. Four studies investigate the different decision outcomes when being socially distant compared to close. Study 1 shows that working in a diverse group is perceived as desirable, but less feasible. Study 2 investigates the impact of psychological distance on individuals' choices of working with a more different (when being socially distant) or similar partner (when being socially close). Study 3 shows that participants created a more diverse team for another person (distance condition) than for themselves (proximity condition). In Study 4, participants did not create a more diverse group for a stranger (distance condition) than for a friend (adjusted proximity condition), however, participants weighted feasibility concerns less strongly for strangers than for friends. Implications for diversity research and practice are discussed

Growth of donor-derived dendritic cells from the bone marrow of murine liver auograft recipients in response to granulocyte/macrophage colony-stimulating factor

Allografts of the liver, which has a comparatively heavy leukocyte content compared with other vascularized organs, are accepted permanently across major histocompatibility complex barriers in many murine strain combinations without immunosuppressive therapy. It has been postulated that this inherent tolerogenicity of the liver may be a consequence of the migration and perpetuation within host lymphoid tissues of potentially tolerogenic donor-derived ("chimeric") leukocytes, in particular, the precursors of chimeric dendritic cells (DC). In this study, we have used granulocyte/macrophage colony-stimulating factor to induce the propagation of progenitors that give rise to DC (CD45+, CDllc+, 33D1+, nonlymphoid dendritic cell 145 +, major histocompatibility complex class II+, B7-1+) in li-tuid cultures of murine bone marrow cells. Using this technique, together with immunocytochemical and molecular methods, we show that, in addition to cells expressing female host (C3H) phenotype (H-2Kk+; I-E+; Y chromosome-), a minor population of male donor (B10)-derived cells (H-2Kb+; I-A+; Y chromosome+) can also be grown in 10-d DC cultures from the bone marrow of liver allograft recipients 14 d after transplant. Highly purified nonlymphoid dendritic cell 145+ DC sorted from these bone marrow-derived cell cultures were shown to comprise ~1-10% cells of donor origin (Y chromosome +) by polymerase chain reaction analysis. In addition, sorted DC stimulated naive, recipient strain T lymphocytes in primary mixed leukocyte cultures. Evidence was also obtained for the growth of donor-derived cells from the spleen but not the thymus. In contrast, donor ceils could not be propagated from the bone marrow or other lymphoid tissues of nonimmunosuppressed C3H mice rejecting cardiac allografrs from the same donor strain (B10). These findings provide a basis for the establishment and perpetuation of cell chimerism after organ transplantation. © 1995, Rockefeller University Press., All rights reserved