Information and communication technology in individual mathematics teaching

The application of information and communication technologies in individual learning are investigated. The analysis shows that the system of tutoring is a necessary form of training aimed at improving the quality of education pupils and studentsИсследуется применение информационно-коммуникационных технологий в индивидуальном обучении. Проведенный анализ показывает, что система репетиторства является необходимой формой обучения, направленной на повышение качества образования учащихся школ и студенто

Impact of Bank Cards Transactions on Banking Fee Income Growth in Russia

The article covers the advent of new sources of income which banks should concentrate on in the light of digitalization and development of new technologies. In spite of dynamic bank cards market development, there are many unresolved issues and challenges in this sphere, which generally relate to the necessity to enhance legal framework regulation; development of effective anti-fraud methods; utilization of innovative technologies and others. The Russian economy and society are in need of highly efficient, safe and economically viable and independent payment system, including such method of payments as bank cards. The conducted analysis revealed that there is a correlation between individual indicators of the bank card market development and the level of a bank's income. The latter depends not only on the revenue flows generated by the growth of interest rates on loans or other conventional types of banking transactions, but on the level of bank cards transactions. It is important to identify correlation between the growth of banks' fee income from card transaction and the amount of funds raised by commercial banks, the numbers of ATM, the average income per card, the number of operating cards, and per capita income of the population

Structural and functional characteristics and properties of metzincins

In this review the main families of endopeptidases belonging to the clan of metzincins of zinc-dependent metal-loproteinases in organisms of wide evolutional range from bacteria to mammals are considered. The data on classification, physicochemical properties, substrate specificity, and structural features of this group of enzymes are given. The activation mechanisms of metzincins, the role of these proteins in organisms, and their participation in various physiological processes are discussed. © 2012 Pleiades Publishing, Ltd

ВИКОРИСТАННЯ ЗАСОБІВ ІНДИВІДУАЛЬНОГО ЗАХИСТУ (МАСОК) У ЗАКЛАДАХ ВИЩОЇ ОСВІТИ: ВІД ТЕОРІЇ ДО ПРАКТИКИ

Purpose: to analyze the attitude of participants in the educational process in medical education institutions regarding the wearing of masks and awareness of their proper use and disposal in accordance with WHO recommendations. Materials and Methods. Research was carried out in eight medical academies and colleges, we studied data on diseases, recommendations for preventing the spread of infection, analysis of questionnaires of survey participants. Results. It was found that almost half of the respondents use reusable masks as a means of preventing infection with COVID-19 on economic grounds, while 10 % of respondents do not use masks at all because they consider them harmful, which increases the growth curve of infection in the educational environment. Conclusions. In order to prevent the intensive spread of coronavirus disease (COVID-19) in higher education institutions, it is necessary to strictly adhere to international protocols and WHO recommendations, to conduct educational work with young people with the involvement of public health experts.Мета: проаналізувати ставлення учасників освітнього процесу в закладах медичної освіти щодо носіння масок та обізнаності їх правильного використання та утилізації згідно з рекомендаціями ВООЗ. Матеріали і методи. Дослідження проведено у восьми вищих медичних навчальних закладах України з використанням теоретичного аналізу та узагальнення даних науково-методичної літератури, дані сучасних досліджень у сфері громадського здоров’я, аналізу анкет анонімного опитування. Результати. Встановлено, що майже половина респондентів використовує багаторазові маски як засіб профілактики зараження на COVID-19 з економічних міркувань, тоді як 10 % респондентів взагалі не використовують маски тому, що вважають їх шкідливими, чим збільшують криву зростання інфікування в освітньому середовищі. Висновки. Для запобігання інтенсивного розповсюдження коронавірусної хвороби (COVID-19) у закладах вищої освіти необхідно чітко дотримуватись міжнародних протоколів і рекомендацій ВООЗ, проводити просвітницьку роботу з молоддю із залученням експертів у галузі громадського здоров’я

PECULIARITIES OF DIAGNOSTICS AND TREATMENT OF SPINAL MALFORMATIONS IN CHILDHOOD

The article presents the results of diagnostics and treatment of 79 patients with pathology of caudal regions of neural tube - fixed spinal cord. On the basis of methods of neurovisualization and. electrophysiology the screening of revealing of pathology of spinal cord (fixed spinal cord) that allows to define the strategy and. tactics of treatment and. to predict outcomes of the disease

Factors Influencing the Formation of Biofilms on Bacilli Model Systems

© 2016, Springer Science+Business Media New York.The ability to form biofilms in natural isolate Bacillus subtilis 168 and mutants with deleted genes of regulatory proteins AbrB, DegU, CcpA, and SpoOA, constructed on its basis, was investigated to elucidate the pathways regulating biofilm formation in B. subtilis. The B. subtilis 168 wild-type forms a biofilms in the liquid medium with maximum at 48th hour of culture growth. pH optimum for the biofilm formation in the wild-type strain is in the range of 7.4–8.0. Temperature optimum was in the range of 22 to 45 °C. The level of biofilm formation for all regulatory mutants was lower than that in the wild-type for 40–50 %. Temperature and pH optima for the mutant strains are the same as for the wild-type strain—7.4–8 pH and temperature of 22–45 °C

Level differentiation technology in vocational education

Differentiated learning technology has been used for a long time. However, with the introduction of innovative educational technologies, it acquires new features and therefore requires additional research. Higher schools are in the process of searching for elements based on a personality-focused approach and introduce the most effective technologies in this process.  The purpose of the article is to discusses the implementation of technologies that provide a single differentiation in the process of preparing students. The characteristic of students' work in differentiated educational conditions is presented. Teaching and training students is arranged in groups. As a result, there is a way to prepare competent students, making them highly qualified professionals. The study shows that there are great opportunities in teaching students of a higher educational institution. The formation of competencies with the help of differentiated learning technology becomes more effective, since individual characteristics of each student are taken into account and their interest and motivation to study a particular course increases. Differentiated tasks allow you to monitor dynamics of the development of students' competence, the systematic implementation of a certain type of tasks that are suitable for certain groups of students.The article presents a study of the level of training of students of the University of the 3rd year of study. The study was conducted in 2018 throughout the school year. Our results are based on data obtained from two groups of students with the same number of subjects. The introduction of differentiated learning technology can improve the quality of training of higher education institutions students. With the help of these technologies, each student, building training in accordance with their personal characteristics and professional needs, achieves success in mastering the material, quickly forms professional competence. The results of the study focused on the quality of training showed that differentiated technologies improve students’ performance

Effect of cultivation conditions on biofilm formation of bacillus subtilis

Biofilms are the moving, constantly changing, heterogeneous bacterial communities. Microorganisms growing in a biofilm are highly resistant to both antimicrobial agents and immune mechanisms. Objective of this paper was to study the effect of extracellular and membrane-bound proteases B. subtilis on the formation of biofilms in liquid media. The strains B. subtilis 168 (wild type) and B. subtilis BRB14 (protease-deficit strain) were examined on the ability to form biofilms in liquid medium. The LB and 1% glucose LB media were used as rich culture medium, and the synthetic E-medium was chosen as poor culture medium. A decreased formation of biofilms by 20% was observed during growth in the glucose-containing LB medium as compared with the glucose-free LB medium. The level of biofilm formation in the synthetic E-medium was 7 times higher than the total level in both LB media. Under identical culture conditions, the ability of mutant strain B. subtilis to form biofilms was 10%-15% higher than the level of biofilm formation by a wild strain. By the 48th hour of growth, the level of biofilm content in the culture of both strains reached maximum and declined significantly by the 72nd hour of growth. pH-Optimum of biofilm formation by both strains B. subtilis was 7.4. The temperature optimum for the formation of biofilms for both strains B. subtilis also ranged from 22°C to 45°C. The results of the studies allow us to conclude that the extracellular and membrane-bound proteinases B. subtilis, deleted in the mutant strain, do not play a key role in the formation of biofilm, however, their effect is more significant during growth of bacteria in a nutrient-rich environment rather than in synthetic one

Neuropathy target esterase in mouse whole blood as a biomarker of exposure to neuropathic organophosphorus compounds

The adult hen is the standard animal model for testing organophosphorus (OP) compounds for organophosphorus compound‐induced delayed neurotoxicity (OPIDN). Recently, we developed a mouse model for biochemical assessment of the neuropathic potential of OP compounds based on brain neuropathy target esterase (NTE) and acetylcholinesterase (AChE) inhibition. We carried out the present work to further develop the mouse model by testing the hypothesis that whole blood NTE inhibition could be used as a biochemical marker for exposure to neuropathic OP compounds. Because brain NTE and AChE inhibition are biomarkers of OPIDN and acute cholinergic toxicity, respectively, we compared NTE and AChE 20‐min IC50 values as well as ED50 values 1 h after single intraperitoneal (i.p.) injections of increasing doses of two neuropathic OP compounds that differed in acute toxicity potency. We found good agreement between the brain and blood for in vitro sensitivity of each enzyme as well for the ratios IC50(AChE)/IC50(NTE). Both OP compounds inhibited AChE and NTE in the mouse brain and blood dose‐dependently, and brain and blood inhibitions in vivo were well correlated for each enzyme. For both OP compounds, the ratio ED50(AChE)/ED50(NTE) in blood corresponded to that in the brain despite the somewhat higher sensitivity of blood enzymes. Thus, our results indicate that mouse blood NTE could serve as a biomarker of exposure to neuropathic OP compounds. Moreover, the data suggest that relative inhibition of blood NTE and AChE provide a way to assess the likelihood that OP compound exposure in a susceptible species would produce cholinergic and/or delayed neuropathic effects. Copyright © 2016 John Wiley & Sons, Ltd.The adult hen is the standard animal model for testing organophosphorus (OP) compounds for organophosphorus compound‐induced delayed neurotoxicity (OPIDN). Recently, we developed a mouse model for the biochemical assessment of the neuropathic potential of OP compounds based on brain neuropathy target esterase (NTE) and acetylcholinesterase (AChE) inhibition. The present work represents further development of the mouse model aimed at using whole blood NTE as a biomarker of exposure to neuropathic OP compounds and predicting OPIDN risk in susceptible species by comparing blood NTE and AChE inhibition.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134102/1/jat3305.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134102/2/jat3305_am.pd

The novel adams-like microbial metalloendopeptidase

Heterologous gene expression of the extracellular minor metalloendopeptidase of Bacillus pumilus 3-19 (AN EU678894) in the protease-deficient B. pumilus 3-19 strain has been studied. The enzyme fraction in the total pool of B. pumilus 3-19 proteases is less than 8%. The enzyme was isolated from the culture liquid of the recombinant strain and purified to a homogeneous state; its primary structure was determined and its physicochemical properties were investigated. The secreted metalloendopeptidase of B. pumilus 3-19 is the first prokaryotic homologue of the eukaryotic adamalysin/reprolysin protein family.© Pleiades Publishing, Ltd., 2012