Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds

RNAi and enzymatic studies have shown the importance of 6-phosphogluconate dehydrogenase (6-PGDH) in Trypanosoma brucei for the parasite survival and make it an attractive drug target for the development of new treatments against human African trypanosomiasis. 2,3-O-Isopropylidene-4-erythrono hydroxamate is a potent inhibitor of parasite Trypanosoma brucei 6-phosphogluconate dehydrogenase (6-PGDH), the third enzyme of the pentose phosphate pathway. However, this compound does not have trypanocidal activity due to its poor membrane permeability. Consequently, we have previously reported a prodrug approach to improve the antiparasitic activity of this inhibitor by converting the phosphate group into a less charged phosphate prodrug. The activity of prodrugs appeared to be dependent on their stability in phosphate buffer. Here we have successfully further extended the development of the aryl phosphoramidate prodrugs of 2,3-O-isopropylidene-4-erythrono hydroxamate by synthesizing a small library of phosphoramidates and evaluating their biological activity and stability in a variety of assays. Some of the compounds showed high trypanocidal activity and good correlation of activity with their stability in fresh mouse blood

Electron beam induced current in InSb-InAs nanowire type-III heterostructures

InSb-InAs nanowire heterostructure diodes investigated by electron beam induced current (EBIC) demonstrate an unusual spatial profile where the sign of the EBIC signal changes in the vicinity of the heterointerface. A qualitative explanation confirmed by theoretical calculations is based on the specific band diagram of the structure representing a type-III heterojunction with an accumulation layer in InAs. The sign of the EBIC signal depends on the specific parameters of this layer. In the course of measurements, the diffusion length of holes in InAs and its temperature dependence are also determined

Two Qubit Quantum Computing in a Projected Subspace

A formulation for performing quantum computing in a projected subspace is presented, based on the subdynamical kinetic equation (SKE) for an open quantum system. The eigenvectors of the kinetic equation are shown to remain invariant before and after interaction with the environment. However, the eigenvalues in the projected subspace exhibit a type of phase shift to the evolutionary states. This phase shift does not destroy the decoherence-free (DF) property of the subspace because the associated fidelity is 1. This permits a universal formalism to be presented - the eigenprojectors of the free part of the Hamiltonian for the system and bath may be used to construct a DF projected subspace based on the SKE. To eliminate possible phase or unitary errors induced by the change in the eigenvalues, a cancellation technique is proposed, using the adjustment of the coupling time, and applied to a two qubit computing system. A general criteria for constructing a DF projected subspace from the SKE is discussed. Finally, a proposal for using triangulation to realize a decoherence-free subsystem based on SKE is presented. The concrete formulation for a two-qubit model is given exactly. Our approach is novel and general, and appears applicable to any type of decoherence. Key Words: Quantum Computing, Decoherence, Subspace, Open System PACS number: 03.67.Lx,33.25.+k,.76.60.-kComment: 24 pages. accepted by Phys. Rev.

Leptomeningeal metastasis from solid tumours: EANO–ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

Central nervous system; Clinical practice guideline; NeurologicalSistema nerviós central; Guia de pràctica clínica; NeurològicSistema nervioso central; Guía de práctica clínica; NeurológicoThis Clinical Practice Guideline provides recommendations for managing leptomeningeal metastases from solid tumours

Electrical properties and band diagram of InSb-InAs nanowire type-III heterojunctions

The electrical properties of nanowire-based n-InSb-n-InAs heterojunctions were investigated theoretically and experimentally. Analysis of the current-voltage characteristics showed that the current through the heterojunction is caused mostly by generation-recombination processes in the InSb and at the heterointerface. Due to the partially overlapping valence band of InSb and the conduction band of InAs, the second process is fast and activationless. Theoretical analysis showed that, depending on the heterojunction parameters, the flux of non-equilibrium minority carriers may have a different direction, explaining the experimentally observed non-monotonic coordinate dependence of the electron beam induced current

Interaction of the Components in Quasi-Ternary Y 2 S(Se) 3 –PbS(Se)–SiS(Se) 2 Systems at 770 K.

Взаємодію між компонентами в системах Y2X3–PbX–SiX2 (X – S, Se) при 770 K вивчено за результатами порошкової дифрактометрії. В системі Y2S3–PbS–SiS2 установлено утворення тетрарної сполуки Y2PbSi2S8 (структурний тип La2PbSi2S8, просторова група R3c, a = 0,88058(2) нм, с = 2,5868(1) нм, RI = 0,0766, RP = 0,1571). У системі Y2Sе3–PbSе–SiSе2 тетрарні сполуки не утворюються. Interaction of the components in the Y2X3–PbX–SiX2 (X – S, Se) systems at 770 K has been determined using X-ray powder diffraction. The formation of the Y2PbSi2S8 compound (La2PbSi2S8 structure type, space group R3c, a = 0,88058(2) nm, с = 2,5868(1) nm, RI = 0,0766, RP = 0,1571) in the Y2S3–PbS–SiS2 system has been established. No quaternary compounds exist in the Y2Sе3–PbSе–SiSе2 system

Interaction of the Components in Quasi-Ternary Y 2 S(Se) 3 –PbS(Se)–SiS(Se) 2 Systems at 770 K

Взаємодію між компонентами в системах Y2X3–PbX–SiX2 (X – S, Se) при 770 K вивчено за результатами порошкової дифрактометрії. В системі Y2S3–PbS–SiS2 установлено утворення тетрарної сполуки Y2PbSi2S8 (структурний тип La2PbSi2S8, просторова група R3c, a = 0,88058(2) нм, с = 2,5868(1) нм, RI = 0,0766, RP = 0,1571). У системі Y2Sе3–PbSе–SiSе2 тетрарні сполуки не утворюються. Interaction of the components in the Y2X3–PbX–SiX2 (X – S, Se) systems at 770 K has been determined using X-ray powder diffraction. The formation of the Y2PbSi2S8 compound (La2PbSi2S8 structure type, space group R3c, a = 0,88058(2) nm, с = 2,5868(1) nm, RI = 0,0766, RP = 0,1571) in the Y2S3–PbS–SiS2 system has been established. No quaternary compounds exist in the Y2Sе3–PbSе–SiSе2 system

КІР У ДІТЕЙ, ПОЄДНАНИЙ З ІНШИМИ ІНФЕКЦІЙНИМИ ЗАХВОРЮВАННЯМИ

The aim of the study was to analyze the peculiarities of the measles course in combination with other infectious diseases in children on the example of clinical cases. The article describes the dynamics of measles clinical course in patients with tick-borne borreliosis and HIV infection during hospital treatment in the Infectious Boxed Department of Air-dropped Infections of the Chernivtsi Regional Children’s Clinical Hospital. It was found that during combination of measles and tick-borne borreliosis, typical clinical symptoms of both diseases with increased erythema migrans were observed on the background of macular-papular rash. The course of pneumonia as the complicated measles at an immunocompromised HIV-infected child with aggressive combination antibacterial and antiretroviral therapy was characterized by a positive prognosis.Метою роботи був аналіз особливостей кору у поєднанні з іншими інфекційними захворюваннями у дітей на прикладі клінічних випадків. Наведено динаміку кору у пацієнтів з кліщовим бореліозом та ВІЛ-інфекцією під час стаціонарного лікування в інфекційному боксованому відділенні крапельних інфекцій обласної дитячої клінічної лікарні м. Чернівці. Установлено, що при поєднаному перебігу кору та кліщового бореліозу спостерігалися типові клінічні симптоми обох захворювань із посиленням мігруючої еритеми на тлі макулопапульозного висипу. Перебіг кору, ускладненого пневмонією в імуноскомпрометованої ВІЛ-інфікованої дитини на тлі агресивної комбінованої антибіотикотерапії при лікуванні антиретровірусними препаратами характеризувався сприятливим прогнозом