Argentinian digital health strategy

Digital Health is one of the three pillars for the effective implementation of Universal Health Coverage in Argentina. The Ministry of Health published the National Digital Health Strategy 2018-2024 in order to establish the conceptual guidelines for the design and development of interoperable health information systems as a state policy. The World Health Organization "National eHealth Strategy Toolkit", "Global Strategy on Digital Health" and other international and local evidence and expert recommendations were taken into account. The path to better healthcare involves adopting systems at the point of care, allowing for the primary recording of information and enabling information exchange through real interoperability. In that way, people, technology and processes will synergize to enhance integrated health service networks. In this paper, we describe the plan and the first two years of implementation of the strategy.Fil: Rizzato Lede, Daniel A.. Ministerio de Salud de la Nación; ArgentinaFil: Pedernera, Federico A.. Ministerio de Salud de la Nación; ArgentinaFil: López, Emiliano. Ministerio de Salud de la Nación; ArgentinaFil: Speranza, Cintia D.. Ministerio de Salud de la Nación; ArgentinaFil: Guevel, Carlos Gustavo. Ministerio de Salud de la Nación; ArgentinaFil: Maid, Jesse J.. Ministerio de Salud de la Nación; ArgentinaFil: Mac Culloch, Patricia. Ministerio de Modernización; ArgentinaFil: Rolandi, Florencia. Ministerio de Modernización; ArgentinaFil: Ayala, Fabiana. Ministerio de Modernización; ArgentinaFil: Abadie, Daniel A.. Ministerio de Modernización; ArgentinaFil: Baqué, María I.. Ministerio de Modernización; ArgentinaFil: Gassino, Fernando. Ministerio de Salud de la Nación; Argentina. Hospital Italiano; ArgentinaFil: Campos, Fernando. Hospital Italiano; ArgentinaFil: Kaminker, Diego. No especifíca;Fil: Cejas, Cintia A.. Ministerio de Salud de la Nación; ArgentinaFil: López Osornio, Alejandro. Ministerio de Salud de la Nación; ArgentinaFil: Rubinstein, Adolfo Luis. Ministerio de Salud de la Nación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentin

La AUH : ¿Nuevo modelo de protección social?

Para la definición de paradigmas o modelos de política social se utiliza como criterio la capacidad del Estado de proveer protección social, tomando en cuenta tanto la extensión de la cobertura como su papel como garante de derechos. Así, la orientación de la política social se ajusta a los requerimientos de la política económica, adaptándola a las necesidades del modelo de desarrollo. Es decir que la visión sobre el funcionamiento del mercado incide sobre la orientación de la intervención social estatal. La pregunta central que se pretende responder en este trabajo es si la política social implementada entre 2003 y 2015 para enfrentar la pobreza y, en particular, la implementación de la AUH representa un quiebre o, más aún, un cambio de modelo en la protección social respecto al modelo aplicado en los ´90. Con este objetivo se examina la evolución de las políticas hacia la pobreza desde los ´90 al 2015, con el objetivo de establecer relaciones, semejanzas y diferencias entre los distintos modelos de intervención. La consideración respecto a si la AUH significó en materia de política social un nuevo paradigma en relación a los modelos anteriores debe enmarcarse en el proyecto económico y social implementado durante el período analizado, sus principales propósitos y la batería de políticas públicas implementadas, tanto en política social como en política económica

The earliest seed plants from Gondwana: paleobiogeographical and evolutionary implications based on Tournaisian (Lower Carboniferous) records from Argentina

The oldest seed occurrences in Western Gondwana have been recognized in a new stratigraphic section located in Western Argentina (Precordillera Basin). Palynological evidence indicates an Early Mississippian (probably Tournaisian) age for this new succession. The two identified early seeds generas, Pseudosporogonites cf. hallei and Warsteinia sancheziae n. sp. were up to now considered as restricted to the Devonian of Laurussia. This finding suggests a dispersal of earliest spermatophytes between Laurussia and Gondwana during Devonian/Tournaisian times, thus accounting for the Rheic Ocean as a surmountable biogeographic barrier for continental biotas. Alternatively, contrasting biogeographic hypotheses dealing with early spermatophytes rising in paleotropics and then displacing herbaceous communities of non-spermatophytes typical from cool high latitudinal regions, are explored for explaining the recognized paleobiogeographical pattern. The new information supports a weak impact of the Devonian/Carboniferous biotic crisis on earliest seed plant diversity. Based on preliminary evidences of niches differentiation and ecological dynamics probably affected by wildfires, Tournaisian Gondwanan plant communities from high latitudes are interpreted as being more complex than previously thought, and more similar to those reported from Laurussia. In addition, their discovery in a sedimentary environment associated to glacigenic deposits, show that this new record might be linked to the coeval glacial age widely recorded elsewhere in Gondwana.Fil: Prestianni, C.. Royal Belgian Institute Of Natural Sciences; BélgicaFil: Rustán, Juan José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Balseiro, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Vaccari, Norberto Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Sterren, Andrea Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Steemans, A. F.. Université de Liège; BélgicaFil: Rubinstein, Claudia Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Astini, Ricardo Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; Argentin

Parsing β-catenin’s cell adhesion and Wnt signaling functions in malignant mammary tumor progression

During malignant progression, epithelial cancer cells dissolve their cell–cell adhesion and gain invasive features. By virtue of its dual function, β-catenin contributes to cadherin-mediated cell–cell adhesion, and it determines the transcriptional output of Wnt signaling: via its N terminus, it recruits the signaling coactivators Bcl9 and Pygopus, and via the C terminus, it interacts with the general transcriptional machinery. This duality confounds the simple loss-of-function analysis of Wnt signaling in cancer progression. In many cancer types including breast cancer, the functional contribution of β-catenin’s transcriptional activities, as compared to its adhesion functions, to tumor progression has remained elusive. Employing the mouse mammary tumor virus (MMTV)–PyMT mouse model of metastatic breast cancer, we compared the complete elimination of β-catenin with the specific ablation of its signaling outputs in mammary tumor cells. Notably, the complete lack of β-catenin resulted in massive apoptosis of mammary tumor cells. In contrast, the loss of β-catenin’s transcriptional activity resulted in a reduction of primary tumor growth, tumor invasion, and metastasis formation in vivo. These phenotypic changes were reflected by stalled cell cycle progression and diminished epithelial–mesenchymal transition (EMT) and cell migration of breast cancer cells in vitro. Transcriptome analysis revealed subsets of genes which were specifically regulated by β-catenin’s transcriptional activities upon stimulation with Wnt3a or during TGF-β–induced EMT. Our results uncouple the signaling from the adhesion function of β-catenin and underline the importance of Wnt/β-catenin–dependent transcription in malignant tumor progression of breast cancer.Fil: Buechel, David. Universidad de Basilea; SuizaFil: Sugiyama, Nami. Universidad de Basilea; SuizaFil: Rubinstein, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biociencias, Biotecnología y Biología Traslacional.; ArgentinaFil: Saxena, Meera. Universidad de Basilea; SuizaFil: Kalathur, Ravi K.R.. Universidad de Basilea; Suiza. Royal Children’s Hospital; AustraliaFil: Lüönd, Fabiana. Universidad de Basilea; SuizaFil: Vafaizadeh, Vida. Universidad de Basilea; SuizaFil: Valenta, Tomas. Universitat Zurich; SuizaFil: Hausmann, George. Universitat Zurich; SuizaFil: Cantù, Claudio. Linköping University; SueciaFil: Basler, Konrad. Universitat Zurich; SuizaFil: Christofori, Gerhard. Universidad de Basilea; Suiz

Parsing β-catenin's cell adhesion and Wnt signaling functions in malignant mammary tumor progression

During malignant progression, epithelial cancer cells dissolve their cell-cell adhesion and gain invasive features. By virtue of its dual function, β-catenin contributes to cadherin-mediated cell-cell adhesion, and it determines the transcriptional output of Wnt signaling: via its N terminus, it recruits the signaling coactivators Bcl9 and Pygopus, and via the C terminus, it interacts with the general transcriptional machinery. This duality confounds the simple loss-of-function analysis of Wnt signaling in cancer progression. In many cancer types including breast cancer, the functional contribution of β-catenin's transcriptional activities, as compared to its adhesion functions, to tumor progression has remained elusive. Employing the mouse mammary tumor virus (MMTV)-PyMT mouse model of metastatic breast cancer, we compared the complete elimination of β-catenin with the specific ablation of its signaling outputs in mammary tumor cells. Notably, the complete lack of β-catenin resulted in massive apoptosis of mammary tumor cells. In contrast, the loss of β-catenin's transcriptional activity resulted in a reduction of primary tumor growth, tumor invasion, and metastasis formation in vivo. These phenotypic changes were reflected by stalled cell cycle progression and diminished epithelial-mesenchymal transition (EMT) and cell migration of breast cancer cells in vitro. Transcriptome analysis revealed subsets of genes which were specifically regulated by β-catenin's transcriptional activities upon stimulation with Wnt3a or during TGF-β-induced EMT. Our results uncouple the signaling from the adhesion function of β-catenin and underline the importance of Wnt/β-catenin-dependent transcription in malignant tumor progression of breast cancer

Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions

SummarySelf-avoidance, a process preventing interactions of axons and dendrites from the same neuron during development, is mediated in vertebrates through the stochastic single-neuron expression of clustered protocadherin protein isoforms. Extracellular cadherin (EC) domains mediate isoform-specific homophilic binding between cells, conferring cell recognition through a poorly understood mechanism. Here, we report crystal structures for the EC1–EC3 domain regions from four protocadherin isoforms representing the α, β, and γ subfamilies. All are rod shaped and monomeric in solution. Biophysical measurements, cell aggregation assays, and computational docking reveal that trans binding between cells depends on the EC1–EC4 domains, which interact in an antiparallel orientation. We also show that the EC6 domains are required for the formation of cis-dimers. Overall, our results are consistent with a model in which protocadherin cis-dimers engage in a head-to-tail interaction between EC1–EC4 domains from apposed cell surfaces, possibly forming a zipper-like protein assembly, and thus providing a size-dependent self-recognition mechanism