National Security Entry-Exit Registration System: Effective Tool Against Terrorism or Unnecessary Infringement on Constitutional Rights?

Article published in the Michigan State University School of Law Student Scholarship Collection

Zooming in on accretion - II. Cold Circumgalactic Gas Simulated with a super-Lagrangian Refinement Scheme

In this study we explore the complex multi-phase gas of the circumgalactic medium (CGM) surrounding galaxies. We propose and implement a novel, super-Lagrangian 'CGM zoom' scheme in the moving-mesh code AREPO, which focuses more resolution into the CGM and intentionally lowers resolution in the dense ISM. We run two cosmological simulations of the same galaxy halo, once with a simple 'no feedback' model, and separately with a more comprehensive physical model including galactic-scale outflows as in the Illustris simulation. Our chosen halo has a total mass of ~10^12 Msun at z ~ 2, and we achieve a median gas mass (spatial) resolution of ~2,200 solar masses (~95 parsecs) in the CGM, six-hundred (fourteen) times better than in the Illustris-1 simulation, a higher spatial resolution than any cosmological simulation at this mass scale to date. We explore the primary channel(s) of cold-phase CGM gas production in this regime. We find that winds substantially enhance the amount of cold gas in the halo, also evidenced in the covering fractions of HI and the equivalent widths of MgII out to large radii, in better agreement with observations than the case without galactic winds. Using a tracer particle analysis to follow the thermodynamic history of gas, we demonstrate how the majority of this cold, dense gas arises due to rapid cooling of the wind material interacting with the hot halo, and how large amounts of cold, ~10^4 K gas can be produced and persist in galactic halos with Tvir ~ 10^6 K. At the resolutions presently considered, the quantitative properties of the CGM we explore are not appreciably affected by the refinement scheme.Comment: MNRAS submitted, comments welcome. High-res version at http://www.mpa-garching.mpg.de/~dnelson/papers/Suresh19_zooming2.pd

Opportunities and challenges for successful use of bevacizumab in pediatrics

Bevacizumab (Avastin) has rapidly gained status as a broadly active agent for malignancies of several different histologies in adults. This activity has spawned a range of uses in pediatrics for both oncologic and non-oncologic indications. Early analyses indicate that pediatric cancers exhibit a spectrum of responses to bevacizumab that suggest its activity may be more limited than in adult oncology. Most exciting, is that for low grade tumors that threaten vision and hearing, there is not only evidence for objective tumor response but for recovery of lost function as well. In addition to oncological indications, there is a range of uses for non-oncologic disease for which bevacizumab has clear activity. Finally, a number of mechanisms have been identified as contributing to bevacizumb resistance in cancer. Elucidating these mechanisms will guide the development of future clinical trials of bevacizumab in pediatric oncology

On the Cosmic Evolution of Fe/Mg in QSO Absorption Line Systems

We investigate the variation of the ratio of the equivalent widths of the FeII$\lambda$2600 line to the MgII$\lambda\lambda$2796,2803 doublet as a function of redshift in a large sample of absorption lines drawn from the JHU-SDSS Absorption Line Catalog. We find that despite large scatter, the observed ratio shows a trend where the equivalent width ratio $\mathcal{R}\equiv W_{\rm FeII}/W_{\rm MgII}$ decreases monotonically with increasing redshift $z$ over the range $0.55 \le z \le 1.90$. Selecting the subset of absorbers where the signal-to-noise ratio of the MgII equivalent width $W_{\rm MgII}$ is $\ge$3 and modeling the equivalent width ratio distribution as a gaussian, we find that the mean of the gaussian distribution varies as $\mathcal{R}\propto (-0.045\pm0.005)z$. We discuss various possible reasons for the trend. A monotonic trend in the Fe/Mg abundance ratio is predicted by a simple model where the abundances of Mg and Fe in the absorbing clouds are assumed to be the result of supernova ejecta and where the cosmic evolution in the SNIa and core-collapse supernova rates is related to the cosmic star-formation rate. If the trend in $\mathcal{R}$ reflects the evolution in the abundances, then it is consistent with the predictions of the simple model.Comment: 10 pages, 4 figures, final version published in MNRA

Pattern of relapse and treatment response in WNT-activated medulloblastoma

Over the past decade, wingless-activated (WNT) medulloblastoma has been identified as a candidate for therapy de-escalation based on excellent survival; however, a paucity of relapses has precluded additional analyses of markers of relapse. To address this gap in knowledge, an international cohort of 93 molecularly confirmed WNT MB was assembled, where 5-year progression-free survival is 0.84 (95%, 0.763-0.925) with 15 relapsed individuals identified. Maintenance chemotherapy is identified as a strong predictor of relapse, with individuals receiving high doses of cyclophosphamide or ifosphamide having only one very late molecularly confirmed relapse (p = 0.032). The anatomical location of recurrence is metastatic in 12 of 15 relapses, with 8 of 12 metastatic relapses in the lateral ventricles. Maintenance chemotherapy, specifically cumulative cyclophosphamide doses, is a significant predictor of relapse across WNT MB. Future efforts to de-escalate therapy need to carefully consider not only the radiation dose but also the chemotherapy regimen and the propensity for metastatic relapses