Clinical Observation On Palipeddone Sustained Release Tablet In The Treatment of Schizophrenia

Objective of this study was to evaluate the efficacy and adverse drug reactions (ADR) of palipeddone sustained release tablet in the treatment of schizophrenia in outpatients. Outpatients with schizophrenia treated with palipeddone sustained release tablet (observation group)in our hospital from Apr. to Sep. in 2009 were followed up and compared with those treated with risperidone (control group) during the same period. PANSS and TESS were applied to evaluate efficacy and ADR. Results suggest that the cure rates were 42.4% for control group and 49.6% for observation group. The effective rates were 74.8% for control group and 80.3% for observation group (

Thermodynamic Geometry and Critical Behavior of Black Holes

Based on the observations that there exists an analogy between the Reissner-Nordstr\"om-anti-de Sitter (RN-AdS) black holes and the van der Waals-Maxwell liquid-gas system, in which a correspondence of variables is $(\phi, q) \leftrightarrow (V,P)$, we study the Ruppeiner geometry, defined as Hessian matrix of black hole entropy with respect to the internal energy (not the mass) of black hole and electric potential (angular velocity), for the RN, Kerr and RN-AdS black holes. It is found that the geometry is curved and the scalar curvature goes to negative infinity at the Davies' phase transition point for the RN and Kerr black holes. Our result for the RN-AdS black holes is also in good agreement with the one about phase transition and its critical behavior in the literature.Comment: Revtex, 18 pages including 4 figure

The impact of combined administration of ropivacaine and dexamethasone on postoperative analgesia in perianal surgery with pudendal nerve block under ultrasound guidance: a prospective randomized controlled study

BackgroundIn recent years, severe pain after perianal surgery has seriously affected the prognosis of hospitalized patients. How to maximize the improvement of postoperative pain and perioperative comfort becomes particularly important.MethodsThis study was a double-blind randomized controlled trial (Registration No.: ChiCTR2100048760, Registration Date: 16 July 2021, Link: www.chictr.org.cn/showproj.html?proj=130226), and patients were randomly divided into two groups: one group underwent postoperative 20 mL bilateral pudendal nerve block with 0.5% ropivacaine (P group), and the other group underwent postoperative 20 mL bilateral pudendal nerve block with 0.5% ropivacaine + 8 mg dexamethasone (PD group). The primary outcome was the incidence of moderate to severe pain at the first postoperative dressing change. Secondary outcomes included Quality of recovery-15 (QoR-15) score at 3 days after surgery, sleep quality, pain score at 3 days after surgery, and incidence of adverse events.ResultsIn the main outcome indicators, the incidence was 41.7% in the P group and 24.2% in the PD group (p = 0.01). The QoR-15 score and sleep quality in PD group were better than those in P group 2 days before surgery. The incidence of postoperative urinary retention was significantly decreased in PD group (p = 0.01).ConclusionLocal anesthesia with dexamethasone combined with pudendal nerve block after perianal surgery can reduce the incidence of moderate to severe pain during the first dressing change. This may be one of the approaches to multimodal analgesia after perianal surgery.Clinical Trial Registrationhttps://www.chictr.org.cn/, identifier ChiCTR2100048760

Polythiophenes comprising conjugated pendantstoward long-term air-stable inverted polymer solar cellswith high open circuit voltages

A series of polythiophenes (PTs) functionalized with bulky conjugated side chains comprising tert-butylsubstituted carbazole (tCz) as an electron donor pendant and bisbenzothiazolylvinyl (DBT) as anelectron acceptor pendant were synthesized via Stille copolymerization for polymer solar cell (PSC)applications. We use the descriptors PTtCz, PT(tCz)0.9(DBT)0.1, PT(tCz)0.64(DBT)0.36, PT(tCz)0.45(DBT)0.55,and PTDBT to identify each of these conjugated polymers, with the names denoting the compositionsof the bulky pendants. The tunable energy levels of the PTs were accomplished by incorporating bothtCz as a donor pendant and DBT as an acceptor pendant, while retaining the low-lying HOMO levels( 5.26 to 5.39 eV). Furthermore, lower bandgaps were observed for the DBT-derived PTs because ofstronger donor–p–acceptor characteristics and more efficient intramolecular charge transfer.Conventional PSCs were fabricated by spin-coating the blend of each PT and the fullerene derivative(PC71BM). The conventional PSC devices exhibited high open circuit voltages (Voc) of around 0.79–0.91 V. The power conversion efficiency (PCE) of the PSCs based on PTtCz : PC71BM (w/w ¼ 1 : 2.5)reached 2.48% with a Voc of 0.91 V, short circuit current (Jsc) of 6.58 (mA cm 2) and fill factor (FF) of41% under the illumination of AM1.5, 100 mW cm 2. Furthermore, a PTtCz/PC71BM-based inverted PSCwith ZnOx and MoO3 as an electron extraction layer and a hole extraction layer respectively was capableof retaining ca. 80% of its original efficiency after storage under ambient conditions (withoutencapsulation) for 1032 h, according to the ISOS-D-1 shelf protocol. The highly durable inverted PSCaccompanied by a large Voc value was achieved for the PT-type polymers

Differentiated rare-element mineralization in an ongonite − topazite composite dike at the Xianghualing tin district, Southern China: an electron-microprobe study on the evolution from niobium-tantalum-oxides to cassiterite

International audienceOur study characterizes in detail the mineralogical, textural and compositional features of a highly evolved, composite ongonite-topazite dike and its magmatic differentiation history. We present compositional data collected by established techniques, i.e. by electron microprobe and wet-chemical analysis, which provide a detailed framework for future studies that employ state-of-the-art analytical techniques. The studied dike (referred to as the No. 431 dike) crops out within the Xianghualing area in the Nanling Range of southern China, in close spatial association with Jurassic Sn-Nb-Ta granite plutons. The rock samples in the No. 431 dike were collected from a structurally lower drill hole and a trench at higher level. The ongonite is encountered throughout the dike, but the topazite is only revealed along the margin of the upper, near-surface dike. The results of whole-rock major and trace element analyses show that the rocks of the No. 431 dike are strongly peraluminous with an average ACNK value of ~ 1.5 for ongonite and > 3.9 for topazite. They are enriched in F, 1.7 wt.% and 5.4 wt.% on average for ongonite and topazite, respectively. The rocks have low Zr/Hf and Nb/Ta ratios, and high levels of ore-forming elements including Nb, Ta, Sn, and W. Silicate and oxide mineral assemblages, textures, and compositions are also distinct for the two rock types studied. In the lower ongonite of the dike, there are abundant phenocrysts of K-feldspar, quartz, and albite, and microphenocrysts of topaz and zinnwaldite in a matrix dominated by quartz, K-feldspar, and albite. Characteristic oxides are columbite-tantalite, tapiolite, and microlite, but cassiterite is absent. The upper ongonite of the dike has a silicate assemblage similar to the lower ongonite; columbite-(Mn), uranomicrolite, and limited amounts of cassiterite are the dominant accessory minerals. The topazite is characterized by large amounts of topaz and zinnwaldite intergrown with quartz, while K-feldspar, albite, and quartz phenocrysts have rounded shapes and are relatively rare. Cassiterite is the most abundant ore mineral, while Nb-Ta oxide minerals are less abundant. We interpret the whole-rock compositional trends, mineral textures, assemblages, and compositions to reflect the differentiation of an evolved, initially homogeneous magma that separated into aluminosilicate and hydrosaline melts, corresponding to crystallization of ongonite and topazite, respectively. The crystallization of Nb-Ta- and Sn-bearing ore minerals was strongly controlled by the separation of the two melt phases. We hypothesize that dike propagation/widening subsequent to the initial dike emplacement may have driven the separation of the aluminosilicate and hydrosaline melt phases that crystallized to ongonite in the core and topazite along the margins of the structurally higher part of the dike

Duration of untreated bipolar disorder: A multicenter study

Little is known about the demographic and clinical differences between short and long duration of untreated bipolar disorder (DUB) in Chinese patients. This study examined the demographic and clinical features of short (≤2 years) and long DUB (\u3e2 years) in China. A consecutively recruited sample of 555 patients with bipolar disorder (BD) was examined in 7 psychiatric hospitals and general hospital psychiatric units across China. Patients’ demographic and clinical characteristics were collected using a standardized protocol and data collection procedure. The mean DUB was 3.2 ± 6.0 years; long DUB accounted for 31.0% of the sample. Multivariate analyses revealed that longer duration of illness, diagnosis of BD type II, and earlier misdiagnosis of BD for major depressive disorder or schizophrenia were independently associated with long DUB. The mean DUB in Chinese BD patients was shorter than the reported figures from Western countries. The long-term impact of DUB on the outcome of BD is warranted

Prevalence and risk factors for diabetic retinopathy in a high-risk Chinese population

BACKGROUND: Lifestyle plays an important role in the development of diabetic retinopathy. The lifestyle in Guangzhou is different from other cities in China as the Cantonese prefer eating rice porridge, but not spicy foods. The objectives of this study were to investigate the prevalence and determinants of diabetic retinopathy in a high-risk population of Guangzhou. METHODS: Subjects (619 totals) aged over 45 years old, without known diabetes were recruited from five randomly selected Guangzhou communities in 2009–2010. All participants were invited to complete the Finnish Diabetes Risk Score (FINDRISC) questionnaire. Subjects with FINDRISC score ≥ 9 were included in the study, and underwent an investigation of demographic data, a standardized physical examination, ocular fundus examination, and laboratory analyses. The minimum criterion for diagnosis of diabetic retinopathy was the presence of at least one microaneurysm. RESULTS: Of 619 subjects, 208 eligible subjects (122 women) with FINDRISC score ≥ 9 were included in the study. The mean age was 69.2 ± 8.5 years. Diabetic retinopathy was detected in 31 subjects, and the prevalence of diabetic retinopathy in subjects with high risk for diabetes was 14.9%. In binary logistic regression analysis, risk factors associated with diabetic retinopathy were history of impaired glucose regulation [odds ratio (OR), 7.194; 95% confidence interval (CI): 1.083, 47.810], higher hemoglobin A1c (HbA1c; OR, 2.912; 95% CI: 1.009, 8.402), higher two-hour postprandial plasma glucose level (OR, 1.014; 95% CI: 1.003, 1.025), and presence of microalbuminuria (OR, 5.387; 95% CI: 1.255, 23.129). CONCLUSIONS: Diabetic retinopathy was prevalent in a high-risk Chinese population from Guangzhou. Histories of impaired glucose regulation and microalbuminuria were strong risk factors for diabetic retinopathy

Testing and Data Reduction of the Chinese Small Telescope Array (CSTAR) for Dome A, Antarctica

The Chinese Small Telescope ARray (hereinafter CSTAR) is the first Chinese astronomical instrument on the Antarctic ice cap. The low temperature and low pressure testing of the data acquisition system was carried out in a laboratory refrigerator and on the 4500m Pamirs high plateau, respectively. The results from the final four nights of test observations demonstrated that CSTAR was ready for operation at Dome A, Antarctica. In this paper we present a description of CSTAR and the performance derived from the test observations.Comment: Accepted Research in Astronomy and Astrophysics (RAA) 1 Latex file and 20 figure

Rapid discrimination of four salmonella enterica serovars: A performance comparison between benchtop and handheld raman spectrometers

Foodborne illnesses, particularly those caused by Salmonella enterica with its extensive array of over 2600 serovars, present a significant public health challenge. Therefore, prompt and precise identification of S. enterica serovars is essential for clinical relevance, which facilitates the understanding of S. enterica transmission routes and the determination of outbreak sources. Classical serotyping methods via molecular subtyping and genomic markers currently suffer from various limitations, such as labour intensiveness, time consumption, etc. Therefore, there is a pressing need to develop new diagnostic techniques. Surface-enhanced Raman spectroscopy (SERS) is a non-invasive diagnostic technique that can generate Raman spectra, based on which rapid and accurate discrimination of bacterial pathogens could be achieved. To generate SERS spectra, a Raman spectrometer is needed to detect and collect signals, which are divided into two types: the expensive benchtop spectrometer and the inexpensive handheld spectrometer. In this study, we compared the performance of two Raman spectrometers to discriminate four closely associated S. enterica serovars, that is, S. enterica subsp. enterica serovar dublin, enteritidis, typhi and typhimurium. Six machine learning algorithms were applied to analyse these SERS spectra. The support vector machine (SVM) model showed the highest accuracy for both handheld (99.97%) and benchtop (99.38%) Raman spectrometers. This study demonstrated that handheld Raman spectrometers achieved similar prediction accuracy as benchtop spectrometers when combined with machine learning models, providing an effective solution for rapid, accurate and cost-effective identification of closely associated S. enterica serovars