Poster: The role of mathematical disciplines in engineering practice

The article describes mathematical education as an essential part of modern engineers' fundamental training system. The research determines the role of mathematics for engineering practice by analyzing responds of survey experts: engineers with PhD and doctoral degrees in the fields of natural sciences and technology and representatives of acting industrial enterprises of Russia. The purpose of this study is to analyze the role of mathematics in engineering practice. Additionally, the task of the paper is to analyze the relationship between students 'experience with school mathematics and their choice of an engineering career. The research uses the Likert scale as the ground basis. As a result of the study, a link was established between the level of proficiency in mathematics at school and the subsequent choice of an engineering specialty by respondents. Over 80% of responding engineers were successful in mathematics at school. High school students, who are successful in mathematics, continue their success as university students. The quality of mathematical education both in high school and at university has a great influence on future engineers. The study showed that professional engineers constantly use mathematical knowledge in their work

Probiotic Potential and Functional Properties of Lactobacillus Reuteri, Lactobacillus Rhamnosus and Lactobacillus Helveticus: A Comparative Study

This study was conducted to evaluate and comparethe probiotic propertiesofLactobacillus helveticusNK1, Lactobacillus rhamnosusF and Lactobacillus reuteriLR1lactobacilli strains.Changes in pH, cell growth, proteolytic activity, antioxidantactivity, and angiotensin-converting enzyme(ACE)inhibitoryactivity were monitored during fermentation ofreconstituted skim milk (RSM) by pure cultures of lactobacilli.Among the tested strains, L. helveticusNK1 showed the highest proteolytic, ACE inhibitoryand antioxidantactivitiesduring milk fermentation,followed by L. rhamnosus F and L. reuteriLR1.The promising capability of all of the lactobacilli strains to release bioactivepeptides from the milk proteins was demonstrated. Keywords: Lactobacillus, probiotic, milk fermentation, bioactive peptide

Project activity in the formation of subject competencies

The project-based learning has long established itself as one of the most stimulating methods of mastering the educational program. However, to study in depth of mathematical disciplines, project tasks must be specifically formulated for the topic being studied. The purpose of this work is to study the methodological relationship between the declared projects and the studied topic of mathematics, as well as a comparative analysis of the results of the development of three mathematical disciplines using the project method and without it. The work on the projects has been carried out for three years at our university and it is aimed at activating the independent cognitive activity of students. In 2018-2019, these were applied and educational projects, the topics for which were selected by teachers. In 2019-2020, students were given the right to independently choose a project topic based on their scientific interests and develop it. In one experimental group, students had the opportunity to consult with the teacher to find a solution to the project problem, in the other such an opportunity was not available. The results of both groups were roughly the same. The conclusion that we came to as a result of this work: project activity increases the horizons of students and allows us to see interdisciplinary connections. Project activity is more effective only if the student works closely with the teacher

Poster: project-based learning in the mathematics course for first year students at a technical university

Project activity is a form of educational and cognitive activity of students, which consists in motivational achievement of a consciously set goal. Project-based learning is increasingly being used in the various academic disciplines around the world. However, the question of when to start using this method effectively remains open. Therefore, the purpose of this article is to study the possibility of using project-based learning in the study of mathematics in the first semester in the first year at a technical University. To study the effectiveness of this method, we conducted a statistical test of the hypothesis of equality of average scores in the intermediate testing, scored by students who studied using the project method and the traditional one. The result of a survey of students about their knowledge of the project method before using it in a mathematics course at the University is presented. It is established that the use of the project-based learning can increase the interest of students in the learning process. The project-based learning has increased the average score of students at the end of the semester by 16.19% compared to the control group

Poster: Technology "The flipped classroom" in the study of mathematics at the technical university

Currently, modern educational technologies are actively used in the educational environment. However, the main method of training remains the traditional method. Therefore, we described and investigated the innovative technology of the flipped classroom in the study of mathematics and compared its effectiveness with traditional learning. As the subject of the research, strategies for using this technology for teaching second-year students mathematics are presented. The subject of study determined the purpose of the study, which is to describe implementation technology of the flipped classroom, focused on the study of the theory of functions of a complex variable. A pedagogical experiment was held at TPU, during which students who studied using the technology of the flipped classroom before a lecture on a specific topic made a summary of this lecture, the material of which was placed in the LMS MOODLE as a PDF file. Students were proposed to take notes of the lecture (if necessary, make notes about what was not clear, so that they could discuss it in class). At the same time, they should have left space in the notebook for proving theorems or for solving examples that demonstrate the use of theoretical material. A pedagogical experiment demonstrated that the use of technology of the flipped classroom improved student achievement. This technology allowed us to present the theoretical material in full. The flipped classroom technology allows you to spend as much time studying a topic as you need to understand it

Using Screencasts in Computer Science Classes at a Technical University

The information technologies applications in various fields of human activity are developing exponentially now. The article considers possibility of using screencasting in a computer science course at a technical university. Screencast is a video that contains a record of actions performed on a computer with the author’s comments. The advantages and disadvantages of this technology in the learning process are considered. It is noted that the technology of on-screen video is distinguished by information richness and strong emotional effect on the student. The application of screencasting in computer science classes at the Tomsk Polytechnic University using the mathematical package MathCad, which has the means to solve all kinds of problems associated with symbolic operations, is presented. The motivation for this study is to increase the student learning process effectiveness. Therefore, the objectives of the study are: to study the possibility of screencasting in the student learning process organization, to study the possibility of using this technology during studying a computer science course, to find out how effectively this method allows to master knowledge in the relevant discipline. The results of study using this technology and the traditional method are analyzed. It is shown that the use of screencasting allows to improve the test results in comparison with the group trained by the traditional method

Convenient Access to Ferrocene Fused <i>aza</i>-Heterocycles via the Intramolecular Ritter Reaction: Synthesis of Novel Racemic Planar-Chiral 3,4-Dihydroferroceno[<i>c</i>]pyridines and 1<i>H</i>-Ferroceno[<i>c</i>]pyrroles

An efficient and easy approach to the synthesis of novel racemic planar-chiral 3,4-dihydroferroceno[c]pyridines and 1H-ferroceno[c]pyrroles via the intramolecular Ritter reaction of 2-ferrocenyl-3,3-dimethylbutan-2-ol with nitriles and thiocyanates in the presence of MeSO3H was developed. Aromatic and aliphatic nitriles, phenylacetonitriles, and β-oxonitriles produced exclusively 3,4-dihydroferroceno[c]pyridines. The condensation of 2-ferrocenyl-3,3-dimethylbutan-2-ol with various thiocyanates, including alkyl thiocyanates, benzyl thiocyanate, and ethyl 2-thiocyanatoacetate, yielded not only 3,4-dihydroferroceno[c]pyridines but also 1H-ferroceno[c]pyrroles. The selectivity of these reactions depended on the temperature and the order of addition. The size of substituents at the α-position to the sulfur atom of thiocyanates also had a significant effect on the distribution of products

Exoproteome Analysis of Antagonistic Interactions between the Probiotic Bacteria Limosilactobacillus reuteri LR1 and Lacticaseibacillus rhamnosus F and Multidrug Resistant Strain of Klebsiella pneumonia

The expansion of multiple drug resistant (MDR) strains of Klebsiella pneumoniae presents an immense threat for public health. Annually, this microorganism causes thousands of lethal nosocomial infections worldwide. Currently, it has been shown that certain strains of lactic acid bacteria (LAB) can efficiently inhibit growth of K. pneumoniae and the formation of its biofilms; however, the active principle of such action remains unknown. In the current article, the growth inhibition of MDR K. pneumoniae by two LAB—Limosilactobacillus reuteri LR1 and Lacticaseibacillus rhamnosus F—is demonstrated, and the nature of this inhibition studied at the level of exoproteome. This article shows that the exoproteomes of studied LAB contains both classically and non-classically secreted proteins. While for L. reuteri LR1 the substantial portion of classically secreted proteins was presented by cell-wall-degrading enzymes, for L. rhamnosus F only one out of four classically secreted proteins was presented by cell-wall hydrolase. Non-classically secreted proteins of both LAB were primarily metabolic enzymes, for some of which a possible moonlighting functioning was proposed. These results contribute to knowledge regarding antagonistic interaction between LAB and pathogenic and opportunistic microorganisms and set new perspectives for the use of LAB to control the spread of these microorganisms

Biochemical and Genomic Characterization of Two New Strains of <i>Lacticaseibacillus paracasei</i> Isolated from the Traditional Corn-Based Beverage of South Africa, Mahewu, and Their Comparison with Strains Isolated from Kefir Grains

Lacticaseibacillus paracasei (formerly Lactobacillus paracasei) is a nomadic lactic acid bacterium (LAB) that inhabits a wide variety of ecological niches, from fermented foodstuffs to host-associated microenvironments. Many of the isolated L. paracasei strains have been used as single-strain probiotics or as part of a symbiotic consortium within formulations. The present study contributes to the exploration of different strains of L. paracasei derived from non-conventional isolation sources—the South African traditional fermented drink mahewu (strains MA2 and MA3) and kefir grains (strains KF1 and ABK). The performed microbiological, biochemical and genomic comparative analyses of the studied strains demonstrated correlation between properties of the strains and their isolation source, which suggests the presence of at least partial strain adaptation to the isolation environments. Additionally, for the studied strains, antagonistic activities against common pathogens and against each other were observed, and the ability to release bioactive peptides with antioxidant and angiotensin I-converting enzyme inhibitory (ACE-I) properties during milk fermentation was investigated. The obtained results may be useful for a deeper understanding of the nomadic lifestyle of L. paracasei and for the development of new starter cultures and probiotic preparations based on this LAB in the future

Development of Antioxidant and Antihypertensive Properties during Growth of Lactobacillus helveticus, Lactobacillus rhamnosus and Lactobacillus reuteri on Cow’s Milk: Fermentation and Peptidomics Study

Bioactive peptides derived from milk proteins are an active research area. Exhibiting numerous positive physiological effects on digestive, cardiovascular, immune and nervous systems, these peptides thought to be one of the most promising ingredients for functional food. Generally, these peptides are inactive within the parent proteins and can be liberated during milk fermentation by the specific proteolytic systems of various Lactobacillus spp. Here we present the study of milk fermentation by Lactobacillus helveticus NK1, Lactobacillus rhamnosus F and Lactobacillus reuteri LR1 strains. It was demonstrated that the antioxidant activity of the milk fermented by these strains concomitantly increased with the strains&rsquo; proteolytic activity. For the angiotensin I-converting enzyme (ACE) inhibitory activity, the same tendency was not observed. Although the proteolytic activity of L. helveticus NK1 was two times higher than that of L. rhamnosus F, the milk fermented by these strains showed comparable ACE inhibition. The analysis of the peptide profiles of the fermented milk samples allowed us to hypothesize that some previously unreported peptides can be produced by L. rhamnosus F. In addition, it was demonstrated that these potential ACE-inhibiting peptides originated from the C-terminus of &alpha;S2-casein