The effect of non-native earthworms on northern Michigan soils.

General Ecology - spring termEarthworms are a non-native species in northern Michigan and their impact on soil structure and ecosystem dynamics is still poorly understood. Alterations in the proportions of nitrogen and carbon in the soil affect primary production, which in turn has consequences for higher trophic levels. Our research investigated the effect of non-native earthworms on carbon and nitrogen in soils of northern Michigan by conducting one manipulative experiment in two soil types and one observational experiment. Our results showed that the total nitrogen and carbon in anecic earthworm burrows was positively correlated with the total values in non-burrows. Also, the earthworms significantly decreased carbon levels in sandy outwash plain soil rather than nutrient rich moraine soil and had negligible effects on nitrogen in both soils. Non-native earthworms catalyze the release of carbon into the atmosphere in outwash plains, therefore, negatively affecting the forest ecosystems. Concurrent with leading research, non-native earthworms stand to be invasive species.http://deepblue.lib.umich.edu/bitstream/2027.42/89444/1/Rozek_Zimmerman_Basham_2011.pd

Breast cancer histology and receptor status characterization in Asian Indian and Pakistani women in the U.S. - a SEER analysis

<p>Abstract</p> <p>Background</p> <p>Recent reports suggest increase in estrogen receptor (ER), progesterone receptor (PR) negative breast cancer yet little is known about histology or receptor status of breast cancer in Indian/Pakistani women.in the U.S.</p> <p>Methods</p> <p>We examined the United States National Cancer Institute's Surveillance Epidemiology and End Results (SEER) Cancer program to assess: a) frequency of breast cancer by age, b) histologic subtypes, c) receptor status of breast cancer and, d) survival in Indians/Pakistanis compared to Caucasians. There were 360,933 breast cancer cases diagnosed 1988-2006. Chi-Square analyses and Cox proportional hazards models, to estimate relative risks for breast cancer mortality after adjusting for confounders, were performed using Statistical Analysis Software 9.2.</p> <p>Results</p> <p>Among Asian Indian/Pakistani breast cancer patients, 16.2% were < 40 yrs. old compared to 6.23% in Caucasians (p < 0.0001). Asian Indian women had more invasive ductal carcinoma (69.1 vs. 65.7%, p < 0.0001), inflammatory cancer (1.4% vs. 0.8, p < 0.0001) and less invasive lobular carcinoma (4.2% vs. 8.1%, p < 0.0001) than Caucasians. Asian Indian/Pakistani women had more ER/PR negative breast cancer (30.6% vs. 21.8%, p = 0.0095) than Caucasians. Adjusting for stage at diagnosis, age, tumor grade, nodal status, and histology, Asian Indian/Pakistani women's survival was similar to Caucasians, while African Americans' was worse.</p> <p>Conclusions</p> <p>Asian Indian/Pakistani women have higher frequency of breast cancer (particularly in age < 40), ER/PR negative invasive ductal and inflammatory cancer than Caucasians.</p

Multidimensional protein fractionation using ProteomeLab PF 2D™ for profiling amyotrophic lateral sclerosis immunity: A preliminary report

Background: The ProteomeLab™ PF 2D platform is a relatively new approach to global protein profiling. Herein, it was used for investigation of plasma proteome changes in amyotrophic lateral sclerosis (ALS) patients before and during immunization with glatiramer acetate (GA) in a clinical trial. Results: The experimental design included immunoaffinity depletion of 12 most abundant proteins from plasma samples with the ProteomeLab™ IgY-12 LC10 column kit as first dimension separation, also referred to as immuno-partitioning. Second and third dimension separations of the enriched proteome were performed on the PF 2D platform utilizing 2D isoelectric focusing and RP-HPLC with the resulting fractions collected for analysis. 1D gel electrophoresis was added as a fourth dimension when sufficient protein was available. Protein identification from collected fractions was performed using nano-LC-MS/MS approach. Analysis of differences in the resulting two-dimensional maps of fractions obtained from the PF 2D and the ability to identify proteins from these fractions allowed sensitivity threshold measurements. Masked proteins in the PF 2D fractions are discussed. Conclusion: We offer some insight into the strengths and limitations of this emerging proteomic platform

Understanding verbal fluency in healthy aging, Alzheimer’s disease, and Parkinson’s disease

This is the author's accepted manuscript. This article may not exactly replicate the final version published in the APA journal. It is not the copy of record.• Objective: Verbal fluency measures are frequently part of batteries designed to assess executive function, but are also used to assess semantic processing ability or word knowledge. The goal of the present study was to identify the cognitive components underlying fluency performance. • Method: Healthy young and older adults, adults with Parkinson’s disease, and adults with Alzheimer’s disease performed letter, category, and action fluency tests. Performance was assessed in terms of number of items generated, clustering, and the time course of output. A series of neuropsychological assessments were also administered to index verbal ability, working memory, executive function, and processing speed as correlates of fluency performance. • Results: Findings indicated that regardless of the particular performance measure, young adults performed the best and adults with Alzheimer’s disease performed most poorly, with healthy older adults and adults with Parkinson’s disease performing at intermediate levels. The exception was the action fluency task, where adults with Parkinson’s disease performed most poorly. The time course of fluency performance was characterized in terms of slope and intercept parameters and related to neuropsychological constructs. Speed of processing was found to be the best predictor of performance, rather than the efficiency of executive function or semantic knowledge. • Conclusions: Together, these findings demonstrate that the pattern of fluency performance looks generally the same regardless of how performance is measured. In addition, the primary role of processing speed in performance suggests that the use of fluency tasks as measures of executive function or verbal ability warrants reexamination.This work was conducted with grant support from the Kansas City Life Sciences Institute. Additional support was provided by the Digital Electronics Core of the Center for Biobehavioral Neurosciences in Communication Disorders, grant number P30 DC-005803, for assistance with the development of the digital ink assessment

Perceptions of Licensure: A Survey of Michigan Genetic Counselors

This study by the Michigan Genetic Counselor Licensure Committee is the first known published documentation of genetic counselors’ beliefs and attitudes about licensure. The response rate from genetic counselors in Michigan was 66% (41/62). Ninety‐five percent of respondents were supportive of licensure. Respondents believed licensure would legitimize genetic counseling as a distinct allied healthcare profession (97.5%), increase the public’s protection (75%), and allow genetic counselors to practice independently (67%). While 45% felt licensure would increase counselor involvement in lawsuits, this did not impact licensure support (p = 0.744). Opinions were split regarding physician supervision and ordering tests. Even though 28% favored physician supervision, there was overwhelming support for genetic counselors performing some components of genetic testing (95%) and ordering some types of genetic tests (82%) independent of a physician. Use of this survey may be helpful in other states to assess genetic counselors’ interest in licensure and for drafting legislation.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147114/1/jgc40357.pd

Environmental engineering applications of electronic nose systems based on MOX gas sensors

Nowadays, the electronic nose (e-nose) has gained a huge amount of attention due to its ability to detect and differentiate mixtures of various gases and odors using a limited number of sensors. Its applications in the environmental fields include analysis of the parameters for environmental control, process control, and confirming the efficiency of the odor-control systems. The e-nose has been developed by mimicking the olfactory system of mammals. This paper investigates e-noses and their sensors for the detection of environmental contaminants. Among different types of gas chemical sensors, metal oxide semiconductor sensors (MOXs) can be used for the detection of volatile compounds in air at ppm and sub-ppm levels. In this regard, the advantages and disadvantages of MOX sensors and the solutions to solve the problems arising upon these sensors’ applications are addressed, and the research works in the field of environmental contamination monitoring are overviewed. These studies have revealed the suitability of e-noses for most of the reported applications, especially when the tools were specifically developed for that application, e.g., in the facilities of water and wastewater management systems. As a general rule, the literature review discusses the aspects related to various applications as well as the development of effective solutions. However, the main limitation in the expansion of the use of e-noses as an environmental monitoring tool is their complexity and lack of specific standards, which can be corrected through appropriate data processing methods applications

General thoughts to the Kaon pair production in the threshold region

Simple--minded thoughts about the cross sections for the reactions pp-->ppK+K- and pp-->ppK0K0 are presented, which certainly do not account for the complex coupled channel problem but rather provide some ideas into the mutual reaction dynamics.Comment: Talk given at 9th International Workshop on Meson Production, Properties and Interaction, Cracow, Poland, 9-13 June 2006. 3 pages, 2 figure

Eta and eta' mesons production at COSY-11

The low emittance and small momentum spread of the proton and deuteron beams of the Cooler Synchrotron COSY combined with the high mass resolution of the COSY-11 detection system permit to study the creation of mesons in the nucleon-nucleon interaction down to the fraction of MeV with respect to the kinematical threshold. At such small excess energies, the ejectiles possess low relative momenta and are predominantly produced with the relative angular momentum equal to zero. Taking advantage of these conditions we have performed investigations aiming to determine the mechanism of the production of eta and eta' mesons in the collision of hadrons as well as the hadronic interaction of these mesons with nucleons and nuclei. In this proceedings we address the ongoing studies of the spin and isospin dependence for the production of the eta and eta' mesons in free and quasi-free nucleon-nucleon collisions. New results on the spin observables for the vec(p)p --> pp eta reaction, combined with the previously determined total cross section isospin dependence, reveal a statistically significant indication that the excitation of the nucleon to the S11(1535) resonance, the process which intermediates the production of the eta meson in the nucleon-nucleon interactions, is predominantly due to the exchange of the pi meson between the colliding nucleons.Comment: Invited talk at MESON 2006: 9th International Workshop on Meson Production, Properties and Interactions, Cracow, Poland, 9-13 Jun 200