A methodology for user-oriented scalability analysis

Scalability analysis provides information about the effectiveness of increasing the number of resources of a parallel system. Several methods have been proposed which use different approaches to provide this information. This paper presents a family of analysis methods oriented to the user. The methods in this family should assist the user in estimating the benefits when increasing the system size. The key issue in the proposal is the appropriate combination of a scaling model, which reflects the way the users utilize an increasing number of resources, and a figure of merit that the user wants to improve with the larger system. Another important element in the proposal is the approach to characterize the scalability, which enables quick visual analyses and comparisons. Finally, three concrete examples of methods belonging to the proposed family are introduced in this paper.Peer ReviewedPostprint (published version

Scaleable microscale perfusion systems for yeast and mammalian cells to accelerate process development of bioproducts

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Practical Outputs to ApplyDigital Tools in Lifelong Learning: Modern Project

The MODERN project aims to help you teach more effectively through incorporating new digitallearning tools into your day to day teaching delivery. It is expected MODERN will be a key resource inteacher and trainersŽ professional development. It has been identified, assessed and categorised thelatest and best digital learning tools. This is a project with a website that has actually had realeducators looking at and rating every tool. Want to find the best tools for creating courses? Done!Want to find the best tool for testing students? Done! Want to find the best tools for project work?Done! In fact, the unique 10 category classification system makes it easy for anyone to find the besttool for the learning objective that anyone wants to achieve

Les proteïnes específiques dels nuclis en els espermatozoides dels mol.luscs

El present treball revisa els estudis efectuats sobre les proteïnes bàsiques específiques en els nuclis espermàtics dels mol·luscs. En la primera part (Característiques de les SBP) fem un repàs de la informació disponible, mentre que en la segona part (Aspectes evolutius de les molècules i de la seva funció) intentem expressar una visió integrada de tals proteïnes i de llurs possibles relacions evolutives

Interaction of nucleoplasmin with core histones

Nucleoplasmin is one of the most abundant proteins in Xenopus laevis oocytes, and it has been involved in the chromatin remodeling that takes place immediately after fertilization. This molecule has been shown to be responsible for the removal of the sperm-specific proteins and deposition of somatic histones onto the male pronuclear chromatin. To better understand the latter process, we have used sedimentation velocity, sedimentation equilibrium, and sucrose gradient fractionation analysis to show that the pentameric form of nucleoplasmin binds to a histone octamer equivalent consisting of equal amounts of the four core histones, H2A, H2B, H3, and H4, without any noticeable preference for any of these proteins. Removal of the histone N-terminal 'tail' domains or the major C-terminal polyglutamic tracts of nucleoplasmin did not alter these binding properties. These results indicate that interactions other than those electrostatic in nature (likely hydrophobic) also play a critical role in the formation of the complex between the negatively charged nucleoplasmin and positively charged histones. Although the association of histones with nucleoplasmin may involve some ionic interactions, the interaction process is not electrostatically driven

Solid polyethylene glycol precipitation: Potential cost reduction in antibody downstream processing

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Network for integrating virtual mobility and european qualifications framework in higher education and continuing education institutions : the virtual project

The main objectives of VIRQUAL are to help educational and training institutions to (a) achieve Virtual Mobility, and (b) guarantee EQF implementation through eLearning. VIRQUAL promotes cooperation and joint work among partner organisations and links with related initiatives. Since summer 2010 the consortium has concentrated in three tasks including the preparation of webinars that will take place in during 2011.Task 1: eLearnig and EQF: a comprehensive analysis of the EQF implementation in Europe compiling 32 country reports on EQF/NQF implementation, at levels 5 to 8 has been collected. Additionally, the situation of e-learning in what concerns legislation and practice in each of the 32 countries was also reported. The analysis of the information pack will allow access to updated information on EQF, recognition of competences and e-learning legislation by country as a consulting instrument.Task 2: Three webinars, each one with one expert invited speaker on the general theme of e-learning and EQF followed by an online discussion with the participants and with the participation in other dissemination events.Task 3: How can we support teachers and curriculum developers defining, writing, or choosing high quality learning outcomes? How can we contribute to a global architecture of learning outcomes/competences? What is a useful classification system for learning 0utcomes/competences? The means to answer these questions is a web-based data base, the ILO repositorywww.learning-outcomes.net. One of the fundaments of its data structure is the classification of learning outcomes according to EQF which distinguishes knowledge, skills and competences