Los criterios que inspiran los contratos modernos en el proyecto de Código Civil y Comercial de la Nación

Fil: Rovira, Alfredo L. Universidad de Buenos Aires. Facultad de Derecho. Cátedra Derecho Comercial. Buenos Aires, Argentin

A probabilistic approach to the visual exploration of G protein-coupled receptor sequences

The study of G protein-coupled receptors (GPCRs) is of great interest in pharmaceutical research, but only a few of their 3D structures are known at present. On the contrary, their amino acid sequences are known and accessible. Sequence analysis can provide new insight on GPCR function. Here, we use a kernel-based statistical machine learning model for the visual exploration of GPCR functional groups from their sequences. This is based on the rich information provided by the model regarding the probability of each sequence belonging to a certain receptor group.Postprint (published version

Chlorophyll content variability in different sugarbeet crop cultivars

Measurement of chlorophyll content with portable meters is an easy way to quantify crop nutrient status, but meter readings are affected by different factors (Martinez and Guiamet, 2004), among which cultivar plays an important role (Chapman and Barreto, 1997). The aim of this work was to study the effect of crop cultivar on chlorophyll readings and to study the relationship of chlorophyll content with yield, quality and other eco-physiological and biochemical parameter

Nitrogen fertilization effect on sugarbeet crop yield and quality

Nitrogen is an essential element in sugarbeet crop growth and yield. However, overfertilization may increase input costs and reduce root quality and sugar production efficiency (Gordo, 2003). Moreover, excess nitrogen causes environmental impacts, so an improved N management is essential to achieve crop sustainability. The aim of this work was to study the effect of nitrogen fertilization on sugarbeet crop yield and quality in the North cultivation zone of Spain

Nitrogen fertilization effect on sugarbeet crop growth and radiation interception

Nitrogen is an essential element in crop growth, yield and quality, while, an improved N management must reduce potential environmental impact. Crop yield is highly correlated with the amount of solar radiation intercepted by the canopy during crop growth cycle, so foliage development is important for growth and yield (Malnou et al., 2006). The aim of this work is to study the effect of nitrogen fertilization on sugarbeet crop growth and radiation use efficiency and interception in a temperate cultivation zone

Laparoscopía estadificadora en cáncer gástrico

En nuestro medio, la mayoría de los carcinomas gástricos son diagnosticados en estadios avanzados y, por lo tanto, con un alto porcentaje de irresecabilidad. La correcta estadificación es esencial para la toma de decisiones terapéuticas y evaluar el pronóstico.Los métodos de estadificación que se encuentran al alcance de nuestros pacientes, como la Ecografía y la Tomografía, presentan una limitada exactitud diagnóstica. El advenimiento de la laparoscopía y su rol en la esta­ dificación tumoral ha cambiado el algoritmo de estudio enmuchos centros. El objetivo de este trabajo es evaluar los resultados de la estadificación laparoscópica y su incidencia en los cambios terapéuticos en relación con la estadificación clínica.

Enzyme activities in vineyard soils long-term treated with copper-based fungicides

Copper-based fungicides have been applied in vineyard soils for a long time, which has resulted in increasing soil Cu concentration. However, information relating to non-target effects of these fungicides on microorganisms of these soils is scarce. The aim of this study was to determine the potential enzyme activities of vineyard soils in relation to Cu content and evaluate the potential risks of long-term application of Cu-based fungicides. For this purpose, a wide range of soil samples, having different total, exchangeable and bioavailable Cu contents, were collected from six regions of quality wines located in the NW Iberian Peninsula, and the activity of dehydrogenase, b-glucosidase, urease and phosphatase were measured. Overall, the results obtained indicate adverse effects of Cu on dehydrogenase, b-glucosidase and phosphatase activities and an inconsistent effect on urease activity. Threshold Cu concentrations at which changes in the enzyme activities became evident were 150e200 mg total Cu kg 1 and 60e80 mg bioavailable Cu kg-1.Xunta de Galici

VAR2CSA Signatures of High Plasmodium falciparum Parasitemia in the Placenta

Plasmodium falciparum infected erythrocytes (IE) accumulate in the placenta through the interaction between Duffy-binding like (DBL) domains of parasite-encoded ligand VAR2CSA and chondroitin sulphate-A (CSA) receptor. Polymorphisms in these domains, including DBL2X and DBL3X, may affect their antigenicity or CSA-binding affinity, eventually increasing parasitemia and its adverse effects on pregnancy outcomes. A total of 373 DBL2X and 328 DBL3X sequences were obtained from transcripts of 20 placental isolates infecting Mozambican women, resulting in 176 DBL2X and 191 DBL3X unique sequences at the protein level. Sequence alignments were divided in segments containing combinations of correlated polymorphisms and the association of segment sequences with placental parasite density was tested using Bonferroni corrected regression models, taking into consideration the weight of each sequence in the infection. Three DBL2X and three DBL3X segments contained signatures of high parasite density (P<0.003) that were highly prevalent in the parasite population (49–91%). Identified regions included a flexible loop that contributes to DBL3X-CSA interaction and two DBL3X motifs with evidence of positive natural selection. Limited antibody responses against signatures of high parasite density among malaria-exposed pregnant women could not explain the increased placental parasitemia. These results suggest that a higher binding efficiency to CSA rather than reduced antigenicity might provide a biological advantage to parasites with high parasite density signatures in VAR2CSA. Sequences contributing to high parasitemia may be critical for the functional characterization of VAR2CSA and the development of tools against placental malaria

VAR2CSA signatures of high Plasmodium falciparum parasitemia in the placenta.

Plasmodium falciparum infected erythrocytes (IE) accumulate in the placenta through the interaction between Duffy-binding like (DBL) domains of parasite-encoded ligand VAR2CSA and chondroitin sulphate-A (CSA) receptor. Polymorphisms in these domains, including DBL2X and DBL3X, may affect their antigenicity or CSA-binding affinity, eventually increasing parasitemia and its adverse effects on pregnancy outcomes. A total of 373 DBL2X and 328 DBL3X sequences were obtained from transcripts of 20 placental isolates infecting Mozambican women, resulting in 176 DBL2X and 191 DBL3X unique sequences at the protein level. Sequence alignments were divided in segments containing combinations of correlated polymorphisms and the association of segment sequences with placental parasite density was tested using Bonferroni corrected regression models, taking into consideration the weight of each sequence in the infection. Three DBL2X and three DBL3X segments contained signatures of high parasite density (P<0.003) that were highly prevalent in the parasite population (49-91%). Identified regions included a flexible loop that contributes to DBL3X-CSA interaction and two DBL3X motifs with evidence of positive natural selection. Limited antibody responses against signatures of high parasite density among malaria-exposed pregnant women could not explain the increased placental parasitemia. These results suggest that a higher binding efficiency to CSA rather than reduced antigenicity might provide a biological advantage to parasites with high parasite density signatures in VAR2CSA. Sequences contributing to high parasitemia may be critical for the functional characterization of VAR2CSA and the development of tools against placental malaria