39 hints to facilitate the use of semantics for data on agriculture and nutrition

In this paper, we report on the outputs and adoption of the Agrisemantics Working Group of the Research Data Alliance (RDA), consisting of a set of recommendations to facilitate the adoption of semantic technologies and methods for the purpose of data interoperability in the field of agriculture and nutrition. From 2016 to 2019, the group gathered researchers and practitioners at the crossing point between information technology and agricultural science, to study all aspects in the life cycle of semantic resources: Conceptualization, edition, sharing, standardization, services, alignment, long term support. First, the working group realized a landscape study, a study of the uses of semantics in agrifood, then collected use cases for the exploitation of semantics resources – a generic term to encompass vocabularies, terminologies, thesauri, ontologies. The resulting requirements were synthesized into 39 “hints” for users and developers of semantic resources, and providers of semantic resource services. We believe adopting these recommendations will engage agrifood sciences in a necessary transition to leverage data production, sharing and reuse and the adoption of the FAIR data principles. The paper includes examples of adoption of those requirements, and a discussion of their contribution to the field of data science

39 Hints to Facilitate the Use of Semantics for Data on Agriculture and Nutrition

In this paper, we report on the outputs and adoption of the Agrisemantics Working Group of the Research Data Alliance (RDA), consisting of a set of recommendations to facilitate the adoption of semantic technologies and methods for the purpose of data interoperability in the field of agriculture and nutrition. From 2016 to 2019, the group gathered researchers and practitioners at the crossing point between information technology and agricultural science, to study all aspects in the life cycle of semantic resources: conceptualization, edition, sharing, standardization, services, alignment, long term support. First, the working group realized a landscape study, a study of the uses of semantics in agrifood, then collected use cases for the exploitation of semantics resources-a generic term to encompass vocabularies, terminologies, thesauri, ontologies. The resulting requirements were synthesized into 39 "hints" for users and developers of semantic resources, and providers of semantic resource services. We believe adopting these recommendations will engage agrifood sciences in a necessary transition to leverage data production, sharing and reuse and the adoption of the FAIR data principles. The paper includes examples of adoption of those requirements, and a discussion of their contribution to the field of data science

Plasmonic Slot Waveguides for Localized Biomolecular Sensing Applications

A plasmonic slot waveguide excited by evanescent wave coupling of a silicon strip waveguide is studied to be used as a label-free biosensor. The plasmonic slot waveguide enables strong electric-field enhancement in a small volume inducing higher interaction between the light and the analyte

Excitation of Metallic Nano-Cavities by a Silicon Waveguide for Localized Sensing Applications

Strong Electric-field enhancement in small volumes is the key for label-free single-molecule sensing. We have investigated the excitation of single and multiple metallic nano-cavities by evanescent wave coupling in the near-infrared by a silicon wire waveguide

Nephrocalcinosis (enamel renal syndrome) caused by autosomal recessive FAM20A mutations

Calcium homeostasis requires regulated cellular and interstitial systems interacting to modulate the activity and movement of this ion. Disruption of these systems in the kidney results in nephrocalcinosis and nephrolithiasis, important medical problems whose pathogenesis is incompletely understood

EVOLUTION DE LA VIRULENCE DE SALMONELLA TYPHIMURIUM SOUS L'EFFET D'UN STRESS (DES BIOL. MED.)

RENNES1-BU Santé (352382103) / SudocSudocFranceF

Impact du dépistage néonatal de la mucoviscidose sur l'état de santé des patients atteints par la maladie (comparaison d'une cohorte de patients mucovisicdosiques bretons dépistés avec une cohorte de patients non dépistés de Loire-Atlantique Vendée)

En 2001, une étude comparait une population de patients nés en Bretagne dont le diagnostic de la mucoviscidose avait été fait après dépistage néonatal avec des patients nés à la même époque en Loire-Atlantique dont le diagnostic avait été fait sur point d'appel. Etaient observés de meilleurs statut nutritionnel, score radiologique de Brasfield et score de Shwachman chez les patients dépistés. 12 ans après, nous avons comparé ces deux mêmes cohortes pour vérifier si les bénéfices du dépistage néonatal perduraient à plus long terme. Nous retrouvons toujours une amélioration du statut nutritionnel qui persiste jusqu'à l'adolescence, et également un délai retardé de colonisation chronique au Pseudomonas aeruginosa. Par contre, nous ne mettons pas en évidence de différence significative sur la fonction respiratoire, probablement du fait de nombreux autres facteurs confondants influençant la fonction respiratoire. Il persiste donc un bénéfice certain au dépistage néonatal de la mucoviscidose avec une amélioration de l'état nutritionnel des patients qui se confirme sur le long terme. L'autre principal intérêt du dépistage fut la création des Centres de Ressources et de Compétences de la Mucoviscidose et l'harmonisation des pratiques, confirmée par la comparaison des pratiques médicales au sein de nos deux cohortes, qui a largement contribué à l'amélioration de la santé des patients atteints.NANTES-BU Médecine pharmacie (441092101) / SudocSudocFranceF

Do we need congenital adrenal hyperplasia screening for premature infants?

International audienceCongenital adrenal hyperplasia neonatal screening has been introduced in France since 1995. A recent survey has questioned its relevance in premature infants because of a high number of false positives and a low positive predictive value of 17-hydroxyprogesterone dosage. A workgroup at the French screening association (Association francaise de depistage et de prevention des handicaps de l'enfant) collected all the epidemiological, clinical and biological data of premature children presenting with adrenal hyperplasia from the national cohort. Their results were compared with those of healthy premature children. All the data showed that the screening in children born before 32 weeks of gestational age is irrelevant, but that it is efficient after this term. A pilot study has been implemented in population to evaluate the opportunity to discontinue this screening in extreme preterm neonates