Powders of Chromium and Chromium Carbides of Different Morphology and Narrow Size Distribution

Powders of Cr and Cr carbides (Cr2C, Cr7C3, and Cr23C6) have been prepared by hydrogen reduction of CrO1.9 and Cr3C2 powders of different morphology, texture and specific surface area. The Cr and Cr carbides particles have the morphology of the parent compound and a narrow size distribution. Depending on the shape, the average size is of the order of some micrometers or some tens of micrometers. Starting with Cr3C2 allows the preparation of Cr powders at a temperature (1000°C) markedly lower than that required when CrO1.9 is used as the precursor (1300°C). However, a Cr3C2 specific surface area of the order of 10 m2/g is necessary to achieve this within a reasonably short time (6 to 12 h). Powders of the lower carbides are prepared by using a milder hydrogen thermal treatment

Elaboration, microstructure and reactivity of Cr3C2 powders of different morphology

Cr,C, powders have been prepared by heat-treatment of metastable chromium oxides of controlled morphology in H2-CH4 atmosphere. Starting with these highly reactive oxides allows formation of Cr,C, at 700°C. The reaction is pseudomorphic and d&rent grain shapes (needles, rods, spheres and polyhedra) have been obtained. The size distribution is narrow and the grain size is generally of the order of a few tens of micrometers, but the "spheres" are in fact made up of aggregates of small platelets about 1.5 pm wide and 0.7 pm thick. The oxidation in air of the carbides was studied by thermal analyses (TGA, DTG and DSC) and was found to proceed in four steps in the 250-700°C range. The differences observed between the carbides are related to their morphology and texture

Essais en bassin du comportement dynamique d'une éolienne flottante sous l'action conjuguée de la houle et du vent

Ce travail porte sur l'étude expérimentale du comportement dynamique d'une éolienne offshore flottante sous l'action conjuguée de la houle et du vent. Pour cela, un nouveau moyen d'essai permettant la génération de vent a été développé sur le bassin de génie océanique de l'École Centrale de Nantes. La qualification aérodynamique de ce dispositif a mis en évidence un faible taux de turbulence et une bonne homogénéité spatiale. Dans un second temps, un modèle réduit d'éolienne flottante a été dimensionné à l'échelle du 1/50e suivant une méthodologie adaptée à ce type d'essai. Le dimensionnement de la maquette est basé sur l'éolienne générique NREL 5MW. Cette éolienne repose sur un flotteur de type semi-submersible (Dutch Tri-floater). Cette maquette a ensuite été étudiée en bassin afin de caractériser son comportement sous l'action de la houle et du vent. L'influence de la directionnalité de la houle et de fluctuations basses fréquences caractéristiques d'un spectre de vent marin est aussi évoquée dans ce document

In vitro prediction of stop-codon suppression by intravenous gentamicin in patients with cystic fibrosis: a pilot study

BACKGROUND: Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which acts as a chloride channel activated by cyclic AMP (cAMP). The most frequent mutation found in 70% of CF patients is F508del, while premature stop mutations are found in about 10% of patients. In vitro aminoglycoside antibiotics (e.g. gentamicin) suppress nonsense mutations located in CFTR permitting translation to continue to the natural termination codon. Pharmacologic suppression of stop mutations within the CFTR may be of benefit to a significant number of patients. Our pilot study was conducted to determine whether intravenous gentamicin suppresses stop codons in CF patients and whether it has clinical benefits. METHODS: A dual gene reporter system was used to determine the gentamicin-induced readthrough level of the most frequent stop mutations within the CFTR in the French population. We investigated readthrough efficiency in response to 10 mg/kg once-daily intravenous gentamicin perfusions in patients with and without stop mutations. Respiratory function, sweat chloride concentration, nasal potential difference (NPD) and CFTR expression in nasal epithelial cells were measured at baseline and after 15 days of treatment. RESULTS: After in vitro gentamicin incubation, the readthrough efficiency for the Y122X mutation was at least five times higher than that for G542X, R1162X, and W1282X. In six of the nine patients with the Y122X mutation, CFTR immunodetection showed protein at the membrane of the nasal epithelial cells and the CFTR-dependent Cl(- )secretion in NPD measurements increased significantly. Respiratory status also improved in these patients, irrespective of the gentamicin sensitivity of the bacteria present in the sputum. Mean sweat chloride concentration decreased significantly and normalised in two patients. Clinical status, NPD and sweat Cl(- )values did not change in the Y122X patients with no protein expression, in patients with the other stop mutations investigated in vitro and those without stop mutations. CONCLUSION: Suppression of stop mutations in the CFTR gene with parenteral gentamicin can be predicted in vitro and is associated with clinical benefit and significant modification of the CFTR-mediated Cl(- )transport in nasal and sweat gland epithelium

Combined Thoracic Ultrasound Assessment during a Successful Weaning Trial Predicts Postextubation Distress

International audienceBackground: Recent studies suggest that isolated sonographic assessment of the respiratory, cardiac, or neuromuscular functions in mechanically ventilated patients may assist in identifying patients at risk of postextubation distress. The aim of the present study was to prospectively investigate the value of an integrated thoracic ultrasound evaluation, encompassing bedside respiratory, cardiac, and diaphragm sonographic data in predicting postextubation distress.Methods: Longitudinal ultrasound data from 136 patients who were extubated after passing a trial of pressure support ventilation were measured immediately after the start and at the end of this trial. In case of postextubation distress (31 of 136 patients), an additional combined ultrasound assessment was performed while the patient was still in acute respiratory failure. We applied machine-learning methods to improve the accuracy of the related predictive assessments.Results: Overall, integrated thoracic ultrasound models accurately predict postextubation distress when applied to thoracic ultrasound data immediately recorded before the start and at the end of the trial of pressure support ventilation (learning sample area under the curve: start, 0.921; end, 0.951; test sample area under the curve: start, 0.972; end, 0.920). Among integrated thoracic ultrasound data, the recognition of lung interstitial edema and the increased telediastolic left ventricular pressure were the most relevant predictive factors. In addition, the use of thoracic ultrasound appeared to be highly accurate in identifying the causes of postextubation distress.Conclusions: The decision to attempt extubation could be significantly assisted by an integrative, dynamic, and fully bedside ultrasonographic assessment of cardiac, lung, and diaphragm functio

My Corporis Fabrica Embryo: An ontology-based 3D spatio-temporal modeling of human embryo development

International audienceBackground: Embryology is a complex morphologic discipline involving a set of entangled mechanisms, sometime difficult to understand and to visualize. Recent computer based techniques ranging from geometrical to physically based modeling are used to assist the visualization and the simulation of virtual humans for numerous domains such as surgical simulation and learning. On the other side, the ontology-based approach applied to knowledge representation is more and more successfully adopted in the life-science domains to formalize biological entities and phenomena, thanks to a declarative approach for expressing and reasoning over symbolic information. 3D models and ontologies are two complementary ways to describe biological entities that remain largely separated. Indeed, while many ontologies providing a unified formalization of anatomy and embryology exist, they remain only descriptive and make the access to anatomical content of complex 3D embryology models and simulations difficult. Results: In this work, we present a novel ontology describing the development of the human embryology deforming 3D models. Beyond describing how organs and structures are composed, our ontology integrates a procedural description of their 3D representations, temporal deformation and relations with respect to their developments. We also created inferences rules to express complex connections between entities. It results in a unified description of both the knowledge of the organs deformation and their 3D representations enabling to visualize dynamically the embryo deformation during the Carnegie stages. Through a simplified ontology, containing representative entities which are linked to spatial position and temporal process information, we illustrate the added-value of such a declarative approach for interactive simulation and visualization of 3D embryos.Conclusions: Combining ontologies and 3D models enables a declarative description of different embryological models that capture the complexity of human developmental anatomy. Visualizing embryos with 3D geometric models and their animated deformations perhaps paves the way towards some kind of hypothesis-driven application. These can also be used to assist the learning process of this complex knowledge.Availability: http://www.mycorporisfabrica.org

The SAFRAN-ISBA-MODCOU hydrometeorological model applied over France

An edited version of this paper was published by AGU. Copyright (2008) American Geophysical UnionThe hydrometeorological model SIM consists in a meterological analysis system (SAFRAN), a land surface model (ISBA) and a hydrogeological model (MODCOU). It generates atmospheric forcing at an hourly time step, and it computes water and surface energy budgets, the river ow at more than 900 rivergauging stations, and the level of several aquifers. SIM was extended over all of France in order to have a homogeneous nation-wide monitoring of the water resources: it can therefore be used to forecast flood risk and to monitor drought risk over the entire nation. The hydrometeorologival model was applied over a 10-year period from 1995 to 2005. In this paper the databases used by the SIM model are presented, then the 10-year simulation is assessed by using the observations of daily stream-flow, piezometric head, and snow depth. This assessment shows that SIM is able to reproduce the spatial and temporal variabilities of the water fluxes. The efficiency is above 0.55 (reasonable results) for 66 % of the simulated rivergages, and above 0.65 (rather good results) for 36 % of them. However, the SIM system produces worse results during the driest years, which is more likely due to the fact that only few aquifers are simulated explicitly. The annual evolution of the snow depth is well reproduced, with a square correlation coeficient around 0.9 over the large altitude range in the domain. The stream ow observations were used to estimate the overall error of the simulated latent heat ux, which was estimated to be less than 4 %