Saltwater Chronicles: reading representational spaces in selected book clubs in St. John's, Newfoundland

Saltwater Chronicles investigates the notion of “islandness” in contemporary Newfoundland readership through two in-depth case studies of book clubs as representational spaces in the elaboration of local knowledge and identities. We demonstrate how select Newfoundland readers perform acts of regeneration in which the lived, loved, and experiential dimensions of literary space come to invoke the permeability of psychic and geographic borders, the dangers and possibilities of the landwash, and the always-already precarious designation of limits between self and other. We provide examples of how, for these island readers, “islandness” as a symbolic point of address slips and border-crosses in the in-between semiotic spaces of literary encounter

Journaling the Art of Teaching: Multimodal Responding for Narrative Inquiry

Research underscores the integral role that teachers’ recurring narratives play in their everyday teaching agendas. Like the students in their classrooms, teachers comprise a diverse group of individuals representing a myriad of ways to learn and teach, stemming from such factors as pedagogical approaches, prior life experiences, and familial relationships. Applying multimodal learning to response journaling expands teacher candidates’ opportunities to address the role that narratives play in developing their daily repertoires of practice in language arts. Hence, further investigation is needed to expand the range of practices available for fostering teacher narrative inquiry. Methodologically supported by action research in relation to narrative inquiry and multimodal learning, we asked, What are the effects of multimodal journaling on the recurring narratives of teacher candidates in a junior-intermediate language/arts methods class

Key Contributions by the Swiss Tropical and Public Health Institute Towards New and Better Drugs for Tropical Diseases

Thanks to its expertise in clinical research, epidemiology, infectious diseases, microbiology, parasitology, public health, translational research and tropical medicine, coupled with deeply rooted partnerships with institutions in low- and middle-income countries (LMICs), the Swiss Tropical and Public Health Institute (Swiss TPH) has been a key contributor in many drug research and development consortia involving academia, pharma and product development partnerships. Our know-how of the maintenance of parasites and their life-cycles in the laboratory, plus our strong ties to research centres and disease control programme managers in LMICs with access to field sites and laboratories, have enabled systems for drug efficacy testing in vitro and in vivo, clinical research, and modelling to support the experimental approaches. Thus, Swiss TPH has made fundamental contributions towards the development of new drugs – and the better use of old drugs – for neglected tropical diseases and infectious diseases of poverty, such as Buruli ulcer, Chagas disease, food-borne trematodiasis (e.g. clonorchiasis, fascioliasis and opisthorchiasis), human African trypanosomiasis, leishmaniasis, malaria, schistosomiasis, soil-transmitted helminthiasis and tuberculosis. In this article, we show case the success stories of molecules to which Swiss TPH has made a substantial contribution regarding their use as anti-infective compounds with the ultimate aim to improve people’s health and well-being

KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission

Renewed global efforts toward malaria eradication have highlighted the need for novel antimalarial agents with activity against multiple stages of the parasite life cycle. We have previously reported the discovery of a novel class of antimalarial compounds in the imidazolopiperazine series that have activity in the prevention and treatment of blood stage infection in a mouse model of malaria. Consistent with the previously reported activity profile of this series, the clinical candidate KAF156 shows blood schizonticidal activity with 50% inhibitory concentrations of 6 to 17.4 nM against P. falciparum drug-sensitive and drug-resistant strains, as well as potent therapeutic activity in a mouse models of malaria with 50, 90, and 99% effective doses of 0.6, 0.9, and 1.4 mg/kg, respectively. When administered prophylactically in a sporozoite challenge mouse model, KAF156 is completely protective as a single oral dose of 10 mg/kg. Finally, KAF156 displays potent Plasmodium transmission blocking activities both in vitro and in vivo. Collectively, our data suggest that KAF156, currently under evaluation in clinical trials, has the potential to treat, prevent, and block the transmission of malaria

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of high priority; however, there are few chemically validated targets. The natural product cladosporin is active against blood- and liver-stage; Plasmodium falciparum; and; Cryptosporidium parvum; in cell-culture studies. Target deconvolution in; P. falciparum; has shown that cladosporin inhibits lysyl-tRNA synthetase (; Pf; KRS1). Here, we report the identification of a series of selective inhibitors of apicomplexan KRSs. Following a biochemical screen, a small-molecule hit was identified and then optimized by using a structure-based approach, supported by structures of both; Pf; KRS1 and; C. parvum; KRS (; Cp; KRS). In vivo proof of concept was established in an SCID mouse model of malaria, after oral administration (ED; 90; = 1.5 mg/kg, once a day for 4 d). Furthermore, we successfully identified an opportunity for pathogen hopping based on the structural homology between; Pf; KRS1 and; Cp; KRS. This series of compounds inhibit; Cp; KRS and; C. parvum; and; Cryptosporidium hominis; in culture, and our lead compound shows oral efficacy in two cryptosporidiosis mouse models. X-ray crystallography and molecular dynamics simulations have provided a model to rationalize the selectivity of our compounds for; Pf; KRS1 and; Cp; KRS vs. (human); Hs; KRS. Our work validates apicomplexan KRSs as promising targets for the development of drugs for malaria and cryptosporidiosis

Financial Policies and Procedures Manuals for Nonprofit Organizations: Applying Best Practices to the Environmental Health Strategy Center

Nonprofit organizations are exempt from taxation specifically because they do not distribute profits to shareholders or owners. It is expected that their purpose is to benefit the public good. Nonprofit organizations rely on public trust to raise the funds needed to carryout their work and to recruit and retain board members and volunteers who can amplify their efforts

Saltwater Chronicles: Reading Representational Spaces in Selected Book Clubs in St. John’s, Newfoundland

Saltwater Chronicles investigates the notion of “islandness” in contemporary Newfoundland readership through two in-depth case studies of book clubs as representational spaces in the elaboration of local knowledge and identities. We demonstrate how select Newfoundland readers perform acts of regeneration in which the lived, loved, and experiential dimensions of literary space come to invoke the permeability of psychic and geographic borders, the dangers and possibilities of the landwash, and the always-already precarious designation of limits between self and other. We provide examples of how, for these island readers, “islandness” as a symbolic point of address slips and border-crosses in the in-between semiotic spaces of literary encounter

Technique [Volume 87, Issue 23]

Academy sets field for 74th annual OscarsA Special Beyond the White and GoldCommittee begins honor reviewCouncil Clippings: HouseCouncil Clippings: SenateDating TV shows: Real romance or really ridiculous?Intramural NotebookIverson breaks ground as circus ringmasterJackets dating Dawgs share romance, rivalryLetters to the EditorMen's Basketball Progress ReportMen's Hoops: Tech (10-15, 3-9 ACC) at Saint Louis (11-14, 5-7 C-USA)News BriefsOUR VIEWS: Consensus OpinionRegents okay Info Security Master'sRegina Tate receives Sportswoman of the Year AwardSliver BoxSports BriefsStaff EditorialStudents keep interstate love going strongTechs and the CityThe Live List...Two BitsUndergrad research picks up steam with website, fundingWashington returns in new film John

Technique [Volume 88, Issue 21]

Affirmative action doesn't help right peopleAsk Dr. CloughBeyond the White and GoldBreaking the BubbleBuried in bills? So are most college studentsCampus Research ReviewDivers lead team to sweep Duke, fall to N.C. StateExtracurricular transcript rewards committmentFirst Miss Asian Atlanta pageant takes over Ferst CenterFreshman students mingle at formalGraduates debate showing of cricketGT responds to safety concernsHorizon Theatre's Wonder of the World a zany journeyHot or NotInfomercials hawk useless productsIntramural Notebook with Jack. B. NimbleJackets 9-0 in ThrillerdomeJackets drop the ball in DurhamLetter makes mistakesMallory leads Lady Jackets to ACC winMeow for new Cat Cove litter boxNew GT ID number, BuzzCard design available March 1NEWS BRIEFSOpinions vary on CS changesOUR VIEWS Consensus OpinionSPORTS BRIEFSStudents could see increased fees next semesterSummer SAC II fees, closure unfairTech grads start record company with community focus...Two BitsUndergrads debate budget amendment

Technique [Volume 87, Issue 14]

Akins to lead young, talented hoops squadAlabama's Meredith named ChancellorBring along some bread crumbs to keep up with Beth Wood's careerBring on the real sportsChemE prof to bring servant tone to leadershipDOAS should have warned of changeDramaTech actors take Thoreau to jailHoops forward Isenhour diagnosed with leukemiaLaziness spawns Tech haute coutureLimited Nuclear Weapons Free ZoneLook out, daddy's little girl is programming now'Monsters, Inc.' monstrous movie funNews BriefsOUR VIEWS Consensus OpinionSGA breezes through bills, off next weekSR-71 warms up on-campus 'RockToberfest'STAFF EDITORIAL: Government is probing too deeply into citizens' livesSTAFF EDITORIAL: Students should strive to become more philanthropicStudent integrity preserves Honor CodeTech community serves cityTechs and the City: Get to know mayoral candidates and exercise your right to voteThirty percent of freshmen earn 'unsatisfactory' marks...Two BitsVideo game takes a hold of my life, my dignityWomen's Swimming and Diving has record-setting debu