Educational change in urban public high schools through college and school partnership : a study of the Boston Secondary Schools Project.

Urban public secondary education has come under constant scrutiny from government agencies, foundations, and educational researchers for more than a decade. It is the quality of public education that is now in question. In conjunction with this trend, is the concern for how this decline of public education may influence the future development of our nation. This dissertation provides some understanding of the complexities of developing and maintaining collaborative programs between academia and the urban secondary schools attempting to achieve effective change. Through an in-depth study of one collaborative, the Boston Secondary Schools Project (BSSP), the study shows how the role of the university or college is of pivotal importance in providing assistance to secondary school educators developing needed changes. In an attempt to remain objective, all aspects of this collaborative were investigated. Included in the study is the organizational structure, growth, evolutionary changes, and the impact of the BSSP on the Boston Public Schools. Additional research was also conducted regarding the value of the program to the participating graduate students. The BSSP has retained its longevity due to the dedication of the University of Massachusetts School of Education faculty, and to the perseverance of the graduate students in their determination to retain the program. The collaborative has been able to include the most essential elements needed to maintain a successful partnership. The program has provided a clear agreement of goals, maintained administrative support, operated under a system of coequality between university and school faculty, worked to overcome the continuous obstacles to its objectives, and has continued to focus on realistic expectations of stated goals

High coherence hybrid superconducting qubit

We measure the coherence of a new superconducting qubit, the {\em low-impedance flux qubit}, finding $T_2^* \sim T_1 \sim 1.5\mu$s. It is a three-junction flux qubit, but the ratio of junction critical currents is chosen to make the qubit's potential have a single well form. The low impedance of its large shunting capacitance protects it from decoherence. This qubit has a moderate anharmonicity, whose sign is reversed compared with all other popular qubit designs. The qubit is capacitively coupled to a high-Q resonator in a $\lambda/2$ configuration, which permits the qubit's state to be read out dispersively

Searching for "monogenic diabetes" in dogs using a candidate gene approach

BACKGROUND: Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenced by genetic factors and similarities between canine and human diabetes phenotypes suggest that the same genes might be associated with disease susceptibility in both species. Between 1-5% of human diabetes cases result from mutations in a single gene, including maturity onset diabetes of the adult (MODY) and neonatal diabetes mellitus (NDM). It is not clear whether monogenic forms of diabetes exist within some dog breeds. Identification of forms of canine monogenic diabetes could help to resolve the heterogeneity of the condition and lead to development of breed-specific genetic tests for diabetes susceptibility. RESULTS: Seventeen dog breeds were screened for single nucleotide polymorphisms (SNPs) in eighteen genes that have been associated with human MODY/NDM. Six SNP associations were found from five genes, with one gene (ZFP57) being associated in two different breeds. CONCLUSIONS: Some of the genes that have been associated with susceptibility to MODY and NDM in humans appear to also be associated with canine diabetes, although the limited number of associations identified in this study indicates canine diabetes is a heterogeneous condition and is most likely to be a polygenic trait in most dog breeds. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2052-6687-1-8) contains supplementary material, which is available to authorized users

A simple all-microwave entangling gate for fixed-frequency superconducting qubits

We demonstrate an all-microwave two-qubit gate on superconducting qubits which are fixed in frequency at optimal bias points. The gate requires no additional subcircuitry and is tunable via the amplitude of microwave irradiation on one qubit at the transition frequency of the other. We use the gate to generate entangled states with a maximal extracted concurrence of 0.88 and quantum process tomography reveals a gate fidelity of 81%

Tremor in motor neuron disease may be central rather than peripheral in origin

BACKGROUND AND PURPOSE: Motor neuron disease (MND) refers to a spectrum of degenerative diseases affecting motor neurons. Recent clinical and post-mortem observations have revealed considerable variability in the phenotype. Rhythmic involuntary oscillations of the hands during action, resembling tremor, can occur in MND, but their pathophysiology has not yet been investigated. METHODS: A total of 120 consecutive patients with MND were screened for tremor. Twelve patients with action tremor and no other movement disorders were found. Ten took part in the study. Tremor was recorded bilaterally using surface electromyography (EMG) and triaxial accelerometer, with and without a variable weight load. Power spectra of rectified EMG and accelerometric signal were calculated. To investigate a possible cerebellar involvement, eyeblink classic conditioning was performed in five patients. RESULTS: Action tremor was present in about 10% of our population. All patients showed distal postural tremor of low amplitude and constant frequency, bilateral with a small degree of asymmetry. Two also showed simple kinetic tremor. A peak at the EMG and accelerometric recordings ranging from 4 to 12 Hz was found in all patients. Loading did not change peak frequency in either the electromyographic or accelerometric power spectra. Compared with healthy volunteers, patients had a smaller number of conditioned responses during eyeblink classic conditioning. CONCLUSIONS: Our data suggest that patients with MND can present with action tremor of a central origin, possibly due to a cerebellar dysfunction. This evidence supports the novel idea of MND as a multisystem neurodegenerative disease and that action tremor can be part of this condition