1,674 research outputs found
Noise spectra of an interacting quantum dot
We study the noise spectra of a many-level quantum dot coupled to two
electron reservoirs, when interactions are taken into account only on the dot
within the Hartree-Fock approximation. The dependence of the noise spectra on
the interaction strength, the coupling to the leads, and the chemical potential
is derived. For zero bias and zero temperature, we find that as a function of
the (external) frequency, the noise exhibits steps and dips at frequencies
reflecting the internal structure of the energy levels on the dot.
Modifications due to a finite bias and finite temperatures are investigated for
a non-interacting two-level dot. Possible relations to experiments are pointed
out.Comment: Added reference
A Novel Mechanism of B Cell-Mediated Immune Suppression through CD73 Expression and Adenosine Production
Immune suppression by regulatory T cells and regulatory B cells is a critical mechanism to limit excess inflammation and autoimmunity. IL-10 is considered the major mediator of B cell induced immune suppression. We report a novel mechanism for immune suppression through adenosine generation by B cells. We identified a novel population of B cells that expresses CD73 as well as CD39, two ectoenzymes that together catalyze the extracellular dephosphorylation of adenine nucleotides to adenosine. Whereas CD39 expression is common among B cells, CD73 expression is not. Approximately 30-50% of B-1 cells (B220(+)CD23(-)) and IL-10 producing B (B10) cells (B220(+)CD5(+)CD1d(hi)) are CD73111, depending on mouse strain, whereas few conventional B-2 cells (B220+CD23+AA4.1) express CD73. In keeping with expression of both CD73 and CD39, we found that CD73(+) B cells produce adenosine in the presence of substrate, whereas B-2 cells do not. CD73(-/-) mice were more susceptible to dextran sulfate sodium salt (DSS)-induced colitis than wild type (WT) mice were, and transfer of CD73+ B cells ameliorated the severity of colitis, suggesting that B cell CD73/CD39/adenosine can modulate DSS-induced colitis. IL-10 production by B cells is not affected by CD73 deficiency. Interestingly, adenosine generation by IL-10(-/-) B cells is impaired because of reduced expression of CD73, indicating an unexpected connection between IL-10 and adenosine and suggesting caution in interpreting the results of studies with IL-10(-/-) cells. Our findings demonstrate a novel regulatory role of B cells on colitis through adenosine generation in an IL10 independent manner
The k-Point Random Matrix Kernels Obtained from One-Point Supermatrix Models
The k-point correlation functions of the Gaussian Random Matrix Ensembles are
certain determinants of functions which depend on only two arguments. They are
referred to as kernels, since they are the building blocks of all correlations.
We show that the kernels are obtained, for arbitrary level number, directly
from supermatrix models for one-point functions. More precisely, the generating
functions of the one-point functions are equivalent to the kernels. This is
surprising, because it implies that already the one-point generating function
holds essential information about the k-point correlations. This also
establishes a link to the averaged ratios of spectral determinants, i.e. of
characteristic polynomials
A nonlinear scalar model of extreme mass ratio inspirals in effective field theory I. Self force through third order
The motion of a small compact object in a background spacetime is
investigated in the context of a model nonlinear scalar field theory. This
model is constructed to have a perturbative structure analogous to the General
Relativistic description of extreme mass ratio inspirals (EMRIs). We apply the
effective field theory approach to this model and calculate the finite part of
the self force on the small compact object through third order in the ratio of
the size of the compact object to the curvature scale of the background (e.g.,
black hole) spacetime. We use well-known renormalization methods and
demonstrate the consistency of the formalism in rendering the self force finite
at higher orders within a point particle prescription for the small compact
object. This nonlinear scalar model should be useful for studying various
aspects of higher-order self force effects in EMRIs but within a comparatively
simpler context than the full gravitational case. These aspects include
developing practical schemes for higher order self force numerical
computations, quantifying the effects of transient resonances on EMRI waveforms
and accurately modeling the small compact object's motion for precise
determinations of the parameters of detected EMRI sources.Comment: 30 pages, 8 figure
Canonical formulation of self-gravitating spinning-object systems
Based on the Arnowitt-Deser-Misner (ADM) canonical formulation of general
relativity, a canonical formulation of gravitationally interacting classical
spinning-object systems is given to linear order in spin. The constructed
position, linear momentum and spin variables fulfill standard Poisson bracket
relations. A spatially symmetric time gauge for the tetrad field is introduced.
The achieved formulation is of fully reduced form without unresolved
constraints, supplementary, gauge, or coordinate conditions. The canonical
field momentum is not related to the extrinsic curvature of spacelike
hypersurfaces in standard ADM form. A new reduction of the tetrad degrees of
freedom to the Einstein form of the metric field is suggested.Comment: 6 pages. v2: extended version; identical to the published one. v3:
corrected misprints in (24) and (39); improved notation; added note regarding
a further reference
Two component dark matter
We explain the PAMELA positron excess and the PPB-BETS/ATIC e+ + e- data
using a simple two component dark matter model (2DM). The two particle species
in the dark matter sector are assumed to be in thermal equilibrium in the early
universe. While one particle is stable and is the present day dark matter, the
second one is metastable and decays after the universe is 10^-8 s old. In this
model it is simple to accommodate the large boost factors required to explain
the PAMELA positron excess without the need for large spikes in the local dark
matter density. We provide the constraints on the parameters of the model and
comment on possible signals at future colliders.Comment: 6 pages, 2 figures, discussion clarified and extende
Alteration of the bZIP60/IRE1 Pathway Affects Plant Response to ER Stress in Arabidopsis thaliana
The Unfolded Protein Response (UPR) is elicited under cellular and environmental stress conditions that disrupt protein folding in the endoplasmic reticulum (ER). Through the transcriptional induction of genes encoding ER resident chaperones and proteins involved in folding, the pathway contributes to alleviating ER stress by increasing the folding capacity in the ER. Similarly to other eukaryotic systems, one arm of the UPR in Arabidopsis is set off by a non-conventional splicing event mediated by ribonuclease kinase IRE1b. The enzyme specifically targets mature bZIP60 RNA for cleavage, which results in a novel splice variant encoding a nuclear localized transcription factor. Although it is clear that this molecular switch widely affects the transcriptome, its exact role in overall plant response to stress has not been established and mutant approaches have not provided much insight. In this study, we took a transgenic approach to manipulate the pathway in positive and negative fashions. Our data show that the ER-resident chaperone BiP accumulates differentially depending on the level of activation of the pathway. In addition, phenotypes of the transgenic lines suggest that BiP accumulation is positively correlated with plant tolerance to chronic ER stress
Constraints on Astro-unparticle Physics from SN 1987A
SN 1987A observations have been used to place constraints on the interactions
between standard model particles and unparticles. In this study we calculate
the energy loss from the supernovae core through scalar, pseudo scalar, vector,
pseudo vector unparticle emission from nuclear bremsstrahlung for degenerate
nuclear matter interacting through one pion exchange. In order to examine the
constraints on we considered the emission of scalar, pseudo
scalar, vector, pseudo vector and tensor through the pair annihilation process
. In addition we have re-examined other pair
annihilation processes. The most stringent bounds on the dimensionless coupling
constants for and are obtained from
nuclear bremsstrahlung process for the pseudo scalar and pseudo-vector
couplings and for
tensor interaction, the best limit on dimensionless coupling is obtained from
and we get .Comment: 12 pages, 2 postscript figure
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Volumetric laser endomicroscopy and its application to Barrett's esophagus: results from a 1,000 patient registry.
Volumetric laser endomicroscopy (VLE) uses optical coherence tomography (OCT) for real-time, microscopic cross-sectional imaging. A US-based multi-center registry was constructed to prospectively collect data on patients undergoing upper endoscopy during which a VLE scan was performed. The objective of this registry was to determine usage patterns of VLE in clinical practice and to estimate quantitative and qualitative performance metrics as they are applied to Barrett's esophagus (BE) management. All procedures utilized the NvisionVLE Imaging System (NinePoint Medical, Bedford, MA) which was used by investigators to identify the tissue types present, along with focal areas of concern. Following the VLE procedure, investigators were asked to answer six key questions regarding how VLE impacted each case. Statistical analyses including neoplasia diagnostic yield improvement using VLE was performed. One thousand patients were enrolled across 18 US trial sites from August 2014 through April 2016. In patients with previously diagnosed or suspected BE (894/1000), investigators used VLE and identified areas of concern not seen on white light endoscopy (WLE) in 59% of the procedures. VLE imaging also guided tissue acquisition and treatment in 71% and 54% of procedures, respectively. VLE as an adjunct modality improved the neoplasia diagnostic yield by 55% beyond the standard of care practice. In patients with no prior history of therapy, and without visual findings from other technologies, VLE-guided tissue acquisition increased neoplasia detection over random biopsies by 700%. Registry investigators reported that VLE improved the BE management process when used as an adjunct tissue acquisition and treatment guidance tool. The ability of VLE to image large segments of the esophagus with microscopic cross-sectional detail may provide additional benefits including higher yield biopsies and more efficient tissue acquisition. Clinicaltrials.gov NCT02215291
Higgs- and Goldstone bosons-mediated long range forces
In certain mild extensions of the Standard Model, spin-independent long range
forces can arise by exchange of two very light pseudoscalar spin--0 bosons. In
particular, we have in mind models in which these bosons do not have direct
tree level couplings to ordinary fermions. Using the dispersion theoretical
method, we find a behaviour of the potential for the exchange of very
light pseudoscalars and a dependence if the pseudoscalars are true
massless Goldstone bosons.Comment: 13 pages (REVTeX), 2 figure
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