9,001 research outputs found
Chemical and mechanical nerve root insults induce differential behavioral sensitivity and glial activation that are enhanced in combination
Both chemical irritation and mechanical compression affect radicular pain from disc herniation. However, relative effects of these insults on pain symptoms are unclear. This study investigated chemical and mechanical contributions for painful cervical nerve root injury. Accordingly, the C7 nerve root separately underwent chromic gut exposure, 10gf compression, or their combination. Mechanical allodynia was assessed, and glial reactivity in the C7 spinal cord tissue was assayed at days 1 and 7 by immunohistochemistry using GFAP and OX-42 as markers of astrocytes and microglia, respectively. Both chromic gut irritation and 10gf compression produced ipsilateral increases in allodynia over sham (p\u3c0.048); combining the two insults significantly (p\u3c0.027) increased ipsilateral allodynia compared to either insult alone. Behavioral hypersensitivity was also produced in the contralateral forepaw for all injuries, but only the combined insult was significantly increased over sham (p\u3c0.031). Astrocytic activation was significantly increased over normal (p\u3c0.001) in the ipsilateral dorsal horn at 1 day after either compression or the combined injury. By day 7, GFAP-reactivity was further increased for the combined injury compared to day 1 (p\u3c0.001). In contrast, spinal OX-42 staining was generally variable, with only mild activation at day 1. By day 7 after the combined injury, there were significant (p\u3c0.003) bilateral increases in OX-42 staining over normal. Spinal astrocytic and microglial reactivity follow different patterns after chemical root irritation, compression, and a combined insult. The combination of transient compression and chemical irritation produces sustained bilateral hypersensitivity, sustained ipsilateral spinal astrocytic activation and late onset bilateral spinal microglial activation
Simulating Three-Dimensional Hydrodynamics on a Cellular-Automata Machine
We demonstrate how three-dimensional fluid flow simulations can be carried
out on the Cellular Automata Machine 8 (CAM-8), a special-purpose computer for
cellular-automata computations. The principal algorithmic innovation is the use
of a lattice-gas model with a 16-bit collision operator that is specially
adapted to the machine architecture. It is shown how the collision rules can be
optimized to obtain a low viscosity of the fluid. Predictions of the viscosity
based on a Boltzmann approximation agree well with measurements of the
viscosity made on CAM-8. Several test simulations of flows in simple geometries
-- channels, pipes, and a cubic array of spheres -- are carried out.
Measurements of average flux in these geometries compare well with theoretical
predictions.Comment: 19 pages, REVTeX and epsf macros require
Two-dimensional hydrodynamic lattice-gas simulations of binary immiscible and ternary amphiphilic fluid flow through porous media
The behaviour of two dimensional binary and ternary amphiphilic fluids under
flow conditions is investigated using a hydrodynamic lattice gas model. After
the validation of the model in simple cases (Poiseuille flow, Darcy's law for
single component fluids), attention is focussed on the properties of binary
immiscible fluids in porous media. An extension of Darcy's law which explicitly
admits a viscous coupling between the fluids is verified, and evidence of
capillary effects are described. The influence of a third component, namely
surfactant, is studied in the same context. Invasion simulations have also been
performed. The effect of the applied force on the invasion process is reported.
As the forcing level increases, the invasion process becomes faster and the
residual oil saturation decreases. The introduction of surfactant in the
invading phase during imbibition produces new phenomena, including
emulsification and micellisation. At very low fluid forcing levels, this leads
to the production of a low-resistance gel, which then slows down the progress
of the invading fluid. At long times (beyond the water percolation threshold),
the concentration of remaining oil within the porous medium is lowered by the
action of surfactant, thus enhancing oil recovery. On the other hand, the
introduction of surfactant in the invading phase during drainage simulations
slows down the invasion process -- the invading fluid takes a more tortuous
path to invade the porous medium -- and reduces the oil recovery (the residual
oil saturation increases).Comment: 48 pages, 26 figures. Phys. Rev. E (in press
Instability of Extremal Relativistic Charged Spheres
With the question, ``Can relativistic charged spheres form extremal black
holes?" in mind, we investigate the properties of such spheres from a classical
point of view. The investigation is carried out numerically by integrating the
Oppenheimer-Volkov equation for relativistic charged fluid spheres and finding
interior Reissner-Nordstr\"om solutions for these objects. We consider both
constant density and adiabatic equations of state, as well as several possible
charge distributions, and examine stability by both a normal mode and an energy
analysis. In all cases, the stability limit for these spheres lies between the
extremal () limit and the black hole limit (). That is, we find
that charged spheres undergo gravitational collapse before they reach ,
suggesting that extremal Reissner-Nordtr\"om black holes produced by collapse
are ruled out. A general proof of this statement would support a strong form of
the cosmic censorship hypothesis, excluding not only stable naked
singularities, but stable extremal black holes. The numerical results also
indicate that although the interior mass-energy obeys the usual stability limit for the Schwarzschild interior solution, the gravitational
mass does not. Indeed, the stability limit approaches as .
In the Appendix we also argue that Hawking radiation will not lead to an
extremal Reissner-Nordstr\"om black hole. All our results are consistent with
the third law of black hole dynamics, as currently understood
Computer simulations of domain growth and phase separation in two-dimensional binary immiscible fluids using dissipative particle dynamics
We investigate the dynamical behavior of binary fluid systems in two
dimensions using dissipative particle dynamics. We find that following a
symmetric quench the domain size R(t) grows with time t according to two
distinct algebraic laws R(t) = t^n: at early times n = 1/2, while for later
times n = 2/3. Following an asymmetric quench we observe only n = 1/2, and if
momentum conservation is violated we see n = 1/3 at early times. Bubble
simulations confirm the existence of a finite surface tension and the validity
of Laplace's law. Our results are compared with similar simulations which have
been performed previously using molecular dynamics, lattice-gas and
lattice-Boltzmann automata, and Langevin dynamics. We conclude that dissipative
particle dynamics is a promising method for simulating fluid properties in such
systems.Comment: RevTeX; 22 pages, 5 low-resolution figures. For full-resolution
figures, connect to http://www.tcm.phy.cam.ac.uk/~ken21/tension/tension.htm
Three dimensional hysdrodynamic lattice-gas simulations of binary immiscible and ternary amphiphilic flow through porous media
We report the results of a study of multiphase flow in porous media. A
Darcy's law for steady multiphase flow was investigated for both binary and
ternary amphiphilic flow. Linear flux-forcing relationships satisfying Onsager
reciprocity were shown to be a good approximation of the simulation data. The
dependence of the relative permeability coefficients on water saturation was
investigated and showed good qualitative agreement with experimental data.
Non-steady state invasion flows were investigated, with particular interest in
the asymptotic residual oil saturation. The addition of surfactant to the
invasive fluid was shown to significantly reduce the residual oil saturation.Comment: To appear in Phys. Rev.
Interface Roughening in a Hydrodynamic Lattice-Gas Model with Surfactant
Using a hydrodynamic lattice-gas model, we study interface growth in a binary
fluid with various concentrations of surfactant. We find that the interface is
smoothed by small concentrations of surfactant, while microemulsion droplets
form for large surfactant concentrations. To assist in determining the
stability limits of the interface, we calculate the change in the roughness and
growth exponents and as a function of surfactant concentration
along the interface.Comment: 4 pages with 4 embedded ps figures. Requires psfig.tex. Will appear
in PRL 14 Oct 199
Effects of interdot dipole coupling in mesoscopic epitaxial Fe(100) dot arrays
The domain structure and the coercivity of epitaxial Fe(100) circular dot arrays of different diameters and separations have been studied using magnetic force microscopy (MFM) and focused magneto-optical Kerr effect (MOKE). The MFM images of the 1 µm diameter single domain dot arrays show direct evidence of strong interdot dipole coupling when the separation is reduced down to 0.1 µm. The coercivity of the dots is also found to be dependent on the separation, indicating the effect of the interdot dipole coupling on the magnetization reversal process
On gravity as an entropic force
We consider E. Verlinde's proposal that gravity is an entropic force -- we
shall call this theory entropic gravity (EG) -- and reanalyze a recent claim
that this theory is in contradiction with the observation of the
gravitationally-bound ground state of neutrons in the GRANIT experiment. We
find that EG does not necessarily contradict the existence of
gravitationally-bound quantum states of neutrons in the Earth's gravitational
field, since EG is equivalent to Newtonian gravity in this case. However,
certain transitions between the gravitationally-bound quantum states of
neutrons, in particular spontaneous decays of excited states, which can
hopefully be observed in future experiments, cannot be explained in the
framework of EG, unless essential ingredients are introduced into it.
Otherwise, a quantized description of gravity will be required.Comment: 6 pages, v2: the possibility that graviton may appear as an emergent
concept in EG is noted, few improvements in arguments and presentation, some
typos and grammar corrected. To appear in Phys. Lett.
Holonomy invariance, orbital resonances, and kilohertz QPOs
Quantized orbital structures are typical for many aspects of classical
gravity (Newton's as well as Einstein's). The astronomical phenomenon of
orbital resonances is a well-known example. Recently, Rothman, Ellis and
Murugan (2001) discussed quantized orbital structures in the novel context of a
holonomy invariance of parallel transport in Schwarzschild geometry. We present
here yet another example of quantization of orbits, reflecting both orbital
resonances and holonomy invariance. This strong-gravity effect may already have
been directly observed as the puzzling kilohertz quasi-periodic oscillations
(QPOs) in the X-ray emission from a few accreting galactic black holes and
several neutron stars
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