2,040 research outputs found
Medicare and GAAP: Understanding the Decision of the Sixth Circuit in \u3ci\u3eGuernsey Memorial Hospital v. Secretary of Health and Human Services\u3c/i\u3e
The Medicare Act entitles qualified providers to reimbursement for the reasonable cost of furnishing hospital services to Medicare beneficiaries. The Sixth Circuit\u27s decision in Guernsey Memorial Hospital demonstrates the tension between generally accepted accounting principles and Medicare reimbursement principles
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Lamina-specific AMPA receptor dynamics following visual deprivation in vivo.
Regulation of AMPA receptor (AMPAR) expression is central to synaptic plasticity and brain function, but how these changes occur in vivo remains elusive. Here, we developed a method to longitudinally monitor the expression of synaptic AMPARs across multiple cortical layers in awake mice using two-photon imaging. We observed that baseline AMPAR expression in individual spines is highly dynamic with more dynamics in primary visual cortex (V1) layer 2/3 (L2/3) neurons than V1 L5 neurons. Visual deprivation through binocular enucleation induces a synapse-specific and depth-dependent change of synaptic AMPARs in V1 L2/3 neurons, wherein deep synapses are potentiated more than superficial synapses. The increase is specific to L2/3 neurons and absent on apical dendrites of L5 neurons, and is dependent on expression of the AMPAR-binding protein GRIP1. Our study demonstrates that specific neuronal connections, across cortical layers and even within individual neurons, respond uniquely to changes in sensory experience
Response of Bose gases in time-dependent optical superlattices
The dynamic response of ultracold Bose gases in one-dimensional optical
lattices and superlattices is investigated based on exact numerical time
evolutions in the framework of the Bose-Hubbard model. The system is excited by
a temporal amplitude modulation of the lattice potential, as it was done in
recent experiments. For regular lattice potentials, the dynamic signatures of
the superfluid to Mott-insulator transition are studied and the position and
the fine-structure of the resonances is explained by a linear response
analysis. Using direct simulations and the perturbative analysis it is shown
that in the presence of a two-colour superlattice the excitation spectrum
changes significantly when going from the homogeneous Mott-insulator the quasi
Bose-glass phase. A characteristic and experimentally accessible signature for
the quasi Bose-glass is the appearance of low-lying resonances and a
suppression of the dominant resonance of the Mott-insulator phase.Comment: 20 pages, 9 figures; added references and corrected typo
Science and Engineering Serials: Issues and Challenges in the Electronic Environment
Pricing Issues: The Core Problem.
Subscription Price Increases.
Fluctuations in the Foreign Exchange Rate.
ISI Impact Factors, Journal Quality, and Cost-Effectiveness.
Questions of Content, Archiving, and Access..
Conclusion.
Reference Notes
Machine Learning for the Prediction of Converged Energies from Ab Initio Nuclear Structure Calculations
The prediction of nuclear observables beyond the finite model spaces that are
accessible through modern ab initio methods, such as the no-core shell model,
pose a challenging task in nuclear structure theory. It requires reliable tools
for the extrapolation of observables to infinite many-body Hilbert spaces along
with reliable uncertainty estimates. In this work we present a universal
machine learning tool capable of capturing observable-specific convergence
patterns independent of nucleus and interaction. We show that, once trained on
few-body systems, artificial neural networks can produce accurate predictions
for a broad range of light nuclei. In particular, we discuss neural-network
predictions of ground-state energies from no-core shell model calculations for
6Li, 12C and 16O based on training data for 2H, 3H and 4He and compare them to
classical extrapolations.Comment: 7 pages, 5 figures, 1 tabl
Pennsylvania Folklife Vol. 21, No. 4
• The Herr and Zeller Houses • Pennsylvania German Astronomy and Astrology II: The Moon • Travel Journals as a Folklife Research Tool: Impressions of the Pennsylvania Germans • My Interview with a Powwower • American Emigrants from the Territories of the Bishropric of Speyer • Emigrants to America from the Duchy of Zweibrucken • Funeral Customs: Folk-Cultural Questionnaire No. 24https://digitalcommons.ursinus.edu/pafolklifemag/1048/thumbnail.jp
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Gut inflammation provides a respiratory electron acceptor for Salmonella.
Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation by using its virulence factors to invade the intestinal epithelium and survive in mucosal macrophages. The inflammatory response enhances the transmission success of S. Typhimurium by promoting its outgrowth in the gut lumen through unknown mechanisms. Here we show that reactive oxygen species generated during inflammation react with endogenous, luminal sulphur compounds (thiosulphate) to form a new respiratory electron acceptor, tetrathionate. The genes conferring the ability to use tetrathionate as an electron acceptor produce a growth advantage for S. Typhimurium over the competing microbiota in the lumen of the inflamed gut. We conclude that S. Typhimurium virulence factors induce host-driven production of a new electron acceptor that allows the pathogen to use respiration to compete with fermenting gut microbes. Thus the ability to trigger intestinal inflammation is crucial for the biology of this diarrhoeal pathogen
Effectiveness of postoperative radiotherapy after radical cystectomy for locally advanced bladder cancer
BACKGROUND: Local-regional failure (LF) for locally advanced bladder cancer (LABC) after radical cystectomy (RC) is common even with chemotherapy and is associated with high morbidity/mortality. Postoperative radiotherapy (PORT) can reduce LF and may enhance overall survival (OS) but has no defined role. We hypothesized that the addition of PORT would improve OS in LABC in a large nationwide oncology database.
METHODS: We identified ≥ pT3pN0-3M0 LABC patients in the National Cancer Database diagnosed 2004-2014 who underwent RC ± PORT. OS was calculated using Kaplan-Meier and Cox proportional hazards regression modeling was used to identify predictors of OS. Propensity matching was performed to match RC patients who received PORT vs those who did not.
RESULTS: 15,124 RC patients were identified with 512 (3.3%) receiving PORT. Median OS was 20.0 months (95% CI, 18.2-21.8) for PORT vs 20.8 months (95% CI, 20.3-21.3) for no PORT (P = 0.178). In multivariable analysis, PORT was independently associated with improved OS: hazard ratio 0.87 (95% CI, 0.78-0.97); P = 0.008. A one-to-three propensity match yielded 1,858 patients (24.9% receiving PORT and 75.1% without). In the propensity-matched cohort, median OS was 19.8 months (95% CI, 18.0-21.6) for PORT vs 16.9 months (95% CI, 15.6-18.1) for no PORT (P = 0.030). In the propensity-matched cohort of urothelial carcinoma patients (N = 1,460), PORT was associated with improved OS for pT4, pN+, and positive margins (P \u3c 0.01 all).
CONCLUSION: In this observational cohort, PORT was associated with improved OS in LABC. While the data should be interpreted cautiously, these results lend support to the use of PORT in selected patients with LABC, regardless of histology. Prospective trials of PORT are warranted
Bose-Fermi mixtures in 1D optical superlattices
The zero temperature phase diagram of binary boson-fermion mixtures in
two-colour superlattices is investigated. The eigenvalue problem associated
with the Bose-Fermi-Hubbard Hamiltonian is solved using an exact numerical
diagonalization technique, supplemented by an adaptive basis truncation scheme.
The physically motivated basis truncation allows to access larger systems in a
fully controlled and very flexible framework. Several experimentally relevant
observables, such as the matter-wave interference pattern and the
condensatefraction, are investigated in order to explore the rich phase
diagram. At symmetric half filling a phase similar to the Mott-insulating phase
in a commensurate purely bosonic system is identified and an analogy to recent
experiments is pointed out. Furthermore a phase of complete localization of the
bosonic species generated by the repulsive boson-fermion interaction is
identified. These localized condensates are of a different nature than the
genuine Bose-Einstein condensates in optical lattices.Comment: 18 pages, 9 figure
Vol. 35, No. 3
A Primer on the Illinois Education-Based Funding for Student Success Act, by Robert Bloch, A. Lynn Himes, Terry L. Hodges, Mitch Roth, Barbara Erickson, and Jack Vrett
Recent Developmentshttps://scholarship.kentlaw.iit.edu/iperr/1105/thumbnail.jp
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