165 research outputs found
Title IX from a Coordinator\u27s Perspective
Transcript of a presentation given during the 2018 Symposium by Title IX Coordinators Kathy Hargis and Stephanie Roth giving a sense of what exactly Title IX provides for and what the scope of Title IX is
Deep Spectroscopy of the Host Galaxy of a Tidal Disruption Flare in A1795
A likely tidal disruption of a star by the intermediate-mass black hole
(IMBH) of a dwarf galaxy was recently identified in association with Abell
1795. Without deep spectroscopy for this very faint object, however, the
possibility of a more massive background galaxy or even a disk-instability
flare from a weak AGN could not be dismissed. We have now obtained 8 hours of
Gemini spectroscopy which unambiguously demonstrate that the host galaxy is
indeed an extremely low-mass
galaxy in Abell 1795, comparable to the least-massive galaxies determined to
host IMBHs via other studies. We find that the spectrum is consistent with the
X-ray flare being due to a tidal disruption event rather than an AGN flare. We
also set improved limits on the black hole mass and infer a 15-year X-ray variability of a factor
of . The confirmation of this galaxy-black hole system provides a
glimpse into a population of galaxies that is otherwise difficult to study, due
to the galaxies' low masses and intrinsic faintness, but which may be important
contributors to the tidal disruption rate.Comment: 9 pages, 4 figures. Accepted by MNRA
Comparing In-Person and Telepractice Service Delivery for Spoken Language Production and Comprehension Using the National Outcomes Measurement System
The American Speech-Language-Hearing Association (ASHA) developed the National Outcomes Measurement System for aggregating standardized patient outcomes. Outcomes are standardized using Functional Communication Measures (FCM), scales designed to describe communicative function across specific areas of clinical need. This investigation compared in-person and telepractice service delivery for children in elementary school settings who received treatment targeting the FCM categories of either “spoken language production” or “spoken language comprehension.” De-identified cases were secured from ASHA’s NOMS database and the database of a private e-learning provider that implemented the NOMS format. There were minimal significant differences in the median change scores between the traditional and telepractice interventions. These results support comparable treatment outcomes between in-person service delivery and telepractice for treatment of children exhibiting impaired spoken language production or spoken language comprehension in an elementary school settin
Therapeutic Targeting of TGFβ Ligands in Glioblastoma Using Novel Antisense Oligonucleotides Reduces the Growth of Experimental Gliomas
PURPOSE
Transforming growth factor (TGF)-β is expressed at high levels by glioma cells and contributes to the malignant phenotype of glioblastoma. However, its therapeutic targeting remains challenging. Here, we examined an alternative therapeutic approach of TGFβ inhibition using two novel phosphorothioate-locked nucleic acid (LNA)-modified antisense oligonucleotide gapmers, ISTH1047 and ISTH0047, which specifically target TGFβ and TGFβ.
EXPERIMENTAL DESIGN
We characterized the effects of ISTH1047 and ISTH0047 on TGFβ expression, downstream signaling and growth of human LN-308, LN-229, and ZH-161 cells as well as murine SMA-560 glioma cells . Furthermore, we assessed their target inhibition and effects on survival in orthotopic xenogeneic and syngeneic rodent glioma models .
RESULTS
Both antisense oligonucleotides specifically silenced their corresponding target and abrogated SMAD2 phosphorylation in several glioma cell lines. Moreover, inhibition of TGFβ or TGFβ expression by ISTH1047 or ISTH0047 reduced the migration and invasiveness of LN-308 and SMA-560 glioma cells. Systemic antisense oligonucleotide administration to glioma-bearing mice suppressed or mRNA expression as well as the expression of the downstream target in orthotopic gliomas. Glioma-bearing mice had significantly prolonged survival upon systemic treatment with ISTH1047 or ISTH0047, which was associated with a reduction of intratumoral SMAD2 phosphorylation and, in a fully immunocompetent model, with increased immune cell infiltration.
CONCLUSIONS
Targeting TGFβ expression with the novel LNA antisense oligonucleotides ISTH1047 or ISTH0047 results in strong antiglioma activity and , which may represent a promising approach to be examined in human patients with glioma
The Hidalgo Project : an experiential study of service-learning in Mexico
vi, 68 leaves : col. ill. ; 29 cm. --This paper describes and analyzes the experience of a Canadian nurse educator and
graduate student who studied and participated in a service-learning project in a rural
community outside the village of Orizabita, in the Municipal District of Ixmiquilpan, in
Hidalgo, Mexico. A successful service-learning experience occurs when a pre-determined
service is provided to an individual or community in need, at the same time providing
students with a rich and rewarding learning experience. The methodology used to study
and evaluate this experience include ethnographic field notes, interviews, and reflective
journaling. The benefits of such an experience include: increased leadership skills, active
involvement in community, heightened awareness of cultural sensitivity and competence,
life skills, and the establishment of partnerships
Evolved Galaxies at z > 1.5 from the Gemini Deep Deep Survey: The Formation Epoch of Massive Stellar Systems
We present spectroscopic evidence from the Gemini Deep Deep Survey (GDDS) for
a significant population of color-selected red galaxies at 1.3 < z < 2.2 whose
integrated light is dominated by evolved stars. Unlike radio-selected objects,
the z > 1.5 old galaxies have a sky density > 0.1 per sq. arcmin. Conservative
age estimates for 20 galaxies with z > 1.3; = 1.49, give a median age of
1.2 Gyr and = 2.4. One quarter of the galaxies have inferred z_f > 4.
Models restricted to abundances less than or equal to solar give median ages
and z_f of 2.3 Gyr and 3.3, respectively. These galaxies are among the most
massive and contribute approximately 50% of the stellar mass density at 1 < z <
2. The derived ages and most probable star formation histories suggest a high
star-formation-rate (300-500 solar masses per year) phase in the progenitor
population. We argue that most of the red galaxies are not descendants of the
typical z=3 Lyman break galaxies. Galaxies associated with luminous sub-mm
sources have the requisite star formation rates to be the progenitor
population. Our results point toward early and rapid formation for a
significant fraction of present day massive galaxies.Comment: 12 pages, 2 figures, 1 table, Accepted for publication, ApJ Letter
Cosmic Star Formation History and its Dependence on Galaxy Stellar Mass
We examine the cosmic star formation rate (SFR) and its dependence on galaxy
stellar mass over the redshift range 0.8 < z < 2 using data from the Gemini
Deep Deep Survey (GDDS). The SFR in the most massive galaxies (M > 10^{10.8}
M_sun) was six times higher at z = 2 than it is today. It drops steeply from z
= 2, reaching the present day value at z ~ 1. In contrast, the SFR density of
intermediate mass galaxies (10^{10.2} < M < 10^{10.8} M_sun) declines more
slowly and may peak or plateau at z ~ 1.5. We use the characteristic growth
time t_SFR = rho_M / rho_SFR to provide evidence of an associated transition in
massive galaxies from a burst to a quiescent star formation mode at z ~ 2.
Intermediate mass systems transit from burst to quiescent mode at z ~ 1, while
the lowest mass objects undergo bursts throughout our redshift range. Our
results show unambiguously that the formation era for galaxies was extended and
proceeded from high to low mass systems. The most massive galaxies formed most
of their stars in the first ~3 Gyr of cosmic history. Intermediate mass objects
continued to form their dominant stellar mass for an additional ~2 Gyr, while
the lowest mass systems have been forming over the whole cosmic epoch spanned
by the GDDS. This view of galaxy formation clearly supports `downsizing' in the
SFR where the most massive galaxies form first and galaxy formation proceeds
from larger to smaller mass scales.Comment: Accepted for publication in ApJ
The Gemini Deep Deep Survey: II. Metals in Star-Forming Galaxies at Redshift 1.3<z<2
The goal of the Gemini Deep Deep Survey (GDDS) is to study an unbiased sample
of K<20.6 galaxies in the redshift range 0.8<z<2.0. Here we determine the
statistical properties of the heavy element enrichment in the interstellar
medium (ISM) of a subsample of 13 galaxies with 1.34<z<1.97 and UV absolute
magnitude M_2000 < -19.65. The sample contains 38% of the total number of
identified galaxies in the first two fields of the survey with z>1.3. The
selected objects have colors typical of irregular and Sbc galaxies. Strong
[OII] emission indicates high star formation activity in the HII regions
(SFR~13-106 M_sun/yr). The high S/N composite spectrum shows strong ISM MgII
and FeII absorption, together with weak MnII and MgI lines. The FeII column
density, derived using the curve of growth analysis, is logN_FeII =
15.54^{+0.23}_{-0.13}. This is considerably larger than typical values found in
damped Ly-alpha systems (DLAs) along QSO sight lines, where only 10 out of 87
(~11%) have logN_FeII > 15.2. High FeII column densities are observed in the
z=2.72 Lyman break galaxy cB58 (logN_FeII ~ 15.25) and in gamma-ray burst host
galaxies (logN_FeII ~ 14.8-15.9). Given our measured FeII column density and
assuming a moderate iron dust depletion (delta_Fe ~ 1 dex), we derive an
optical dust extinction A_V ~ 0.6. If the HI column density is log N(HI)<21.7
(as in 98% of DLAs), then the mean metallicity is Z/Z_sun > 0.2. The high
completeness of the GDDS sample implies that these results are typical of
star-forming galaxies in the 1<z<2 redshift range, an epoch which has
heretofore been particularly challenging for observational programs.Comment: ApJ in press, corrected HI column density estimat
Gemini Deep Deep Survey VI: Massive Hdelta-strong galaxies at z=1
We show that there has been a dramatic decline in the abundance of massive
galaxies with strong Hdelta stellar absorption lines from z=1.2 to the present.
These ``Hdelta-strong'', or HDS, galaxies have undergone a recent and rapid
break in their star-formation activity. Combining data from the Gemini Deep
Deep and the Sloan Digital Sky Surveys to make mass-matched samples
(M*>=10^10.2 Msun), with 25 and 50,255 galaxies, respectively), we find that
the fraction of galaxies in an HDS phase has decreased from about 50% at z=1.2
to a few percent today. This decrease in fraction is due to an actual decrease
in the number density of massive HDS systems by a factor of 2-4, coupled with
an increase in the number density of massive galaxies by about 30 percent. We
show that this result depends only weakly on the threshold chosen for the
Hdelta equivalent width to define HDS systems (if greater than 4 A) and
corresponds to a (1+z)^{2.5\pm 0.7} evolution. Spectral synthesis studies of
the high-redshift population using the PEGASE code, treating Hdelta_A, EW[OII],
Dn4000, and rest-frame colors, favor models in which the Balmer absorption
features in massive Hdelta-strong systems are the echoes of intense episodes of
star-formation that faded about 1 Gyr prior to the epoch of observation. The
z=1.4-2 epoch appears to correspond to a time at which massive galaxies are in
transition from a mode of sustained star formation to a relatively quiescent
mode with weak and rare star-formation episodes. We argue that the most likely
local descendants of the distant massive HDS galaxies are passively evolving
massive galaxies in the field and small groups.Comment: 16 pages, 12 figures, 3 tables, uses emulateapj.sty; updated to match
the version accepted by ApJ. One figure added, conclusions unchange
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